| Interacting proteins: Q9BZK7 and O75376 |
Pubmed |
SVM Score :0.0 |
| Purification and functional characterization of the human N CoR complex : the roles of HDAC 3 , TBL 1 and TBLR 1 . ^^^ Corepressors N CoR and SMRT participate in diverse repression pathways and exist in large protein complexes including HDAC 3 , TBL 1 and TBLR 1 . ^^^ |
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| Interacting proteins: Q9BZK7 and O75376 |
Pubmed |
SVM Score :0.0 |
| Fusion protein of retinoic acid receptor alpha with promyelocytic leukemia protein or promyelocytic leukemia zinc finger protein recruits N CoR TBLR 1 corepressor complex to repress transcription in vivo . ^^^ We first show that the endogenous corepressor N CoR forms a complex with TBLR 1 ( transducin beta like protein 1 related protein ) and that both N CoR and TBLR 1 can interact with unliganded PML RARalpha and PLZF RARalpha in vivo . ^^^ Using chromatin immunoprecipitation , we demonstrate that both oncoproteins recruit TBLR 1 , as well as N CoR , to its target promoter , leading to histone deacetylation and transcriptional repression . ^^^ Furthermore , expression of a dominant negative N CoR that contains the TBLR 1 interacting domain blocks transcription repression by unliganded PML RARalpha and PLZF RARalpha . ^^^ Thus , our studies provide in vivo evidence for targeted recruitment of N CoR TBLR 1 complexes by PML RARalpha and PLZF RARalpha in transcriptional repression in the context of chromatin . . ^^^ |
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| Interacting proteins: Q9BZK7 and O75376 |
Pubmed |
SVM Score :0.0 |
| Here , we report that transcriptional activation mediated by liganded nuclear receptors unexpectedly requires the actions of two highly related F box / WD 40 containing factors , TBL 1 and TBLR 1 , initially identified as components of an N CoR corepressor complex . ^^^ TBL1 / TBLR1 serve as specific adaptors for the recruitment of the ubiquitin conjugating / 19S proteasome complex , with TBLR 1 selectively serving to mediate a required exchange of the nuclear receptor corepressors , N CoR and SMRT , for coactivators upon ligand binding . ^^^ |
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| Interacting proteins: Q9BZK7 and O75376 |
Pubmed |
SVM Score :0.0 |
| Although the N terminal RD binds transducin beta like protein 1 ( TBL 1 ) , TBLR 1 , and mSin 3 , deletion of this region did not affect the ability of N CoR to mediate repression by TR . ^^^ |
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| Interacting proteins: Q9BZK7 and O75376 |
Pubmed |
SVM Score :0.0 |
| Since Sif2p appears to be the yeast homolog of human TBL 1 and TBLR 1 , which function in the N CoR / SMRT complexes , its structural and oligomeric properties are likely to be very similar . . ^^^ |
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| Interacting proteins: Q9BZK7 and O75376 |
Pubmed |
SVM Score :0.0 |
| Cells engineered to over express either TBLR 1 or N and C terminal deletion variants , have elevated levels of endogenous N CoR . ^^^ |
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