| Interacting proteins: Q14995 and O75376 |
Pubmed |
SVM Score :0.63340193 |
| The present investigation demonstrates that two corepressor interaction regions , CIR 1 and CIR 2 , separated by approximately 150 amino acids in the E region of RVR , are required for the interaction with N CoR , RIP13a , and RIP 13 delta A . 0.63340193^^^ |
|
| Interacting proteins: Q14995 and O75376 |
Pubmed |
SVM Score :0.0 |
| Two receptor interaction domains in the corepressor , N CoR / RIP13 , are required for an efficient interaction with Rev erbA alpha and RVR : physical association is dependent on the E region of the orphan receptors . ^^^ Detailed deletion analysis of the orphan receptor interaction with RIP13 / N CoR rigorously demonstrated that the physical association was critically dependent on an intact E region of Rev erbA alpha and RVR . ^^^ In conclusion , these data from two independent approaches demonstrate that repression by Rev erbA alpha and RVR is mediated by an interaction of ID 1 and ID 2 of N CoR , RIP13a and delta 1 with the putative ligand binding domain of the orphan receptors . . ^^^ |
|
| Interacting proteins: Q14995 and O75376 |
Pubmed |
SVM Score :0.0 |
| Rev erbA / RVR are closely related orphan nuclear receptors ( NRs ) functioning as dominant transcriptional silencers through an association with the nuclear receptor corepressor N CoR . ^^^ Mutation of specific residues from this surface severely impaired the in vitro and in vivo interaction of the Rev erbA / RVR LBD with the receptor interacting domain of the corepressors N CoR or its splice variant RIP13delta1 , reinforcing the view of the physical association of N CoR with a LBD surface encompassing H 3 H4 and H 11 . ^^^ |
|