| Interacting proteins: Q06455 and O75376 |
Pubmed |
SVM Score :0.94711644 |
| Here we demonstrate that ETO interacts with the nuclear receptor corepressor N CoR , the mSin 3 corepressors , and histone deacetylases . 0.94711644^^^ |
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| Interacting proteins: Q06455 and O75376 |
Pubmed |
SVM Score :0.99295749 |
| The N terminal portion of ETO forms complexes with PLZF , while the C terminal region , which was shown to bind to N CoR and SMRT , is required for the ability of ETO to augment transcriptional repression by PLZF . 0.99295749^^^ |
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| Interacting proteins: Q06455 and O75376 |
Pubmed |
SVM Score :0.0 |
| ETO , fusion partner in t ( 8 ; 21 ) acute myeloid leukemia , represses transcription by interaction with the human N CoR / mSin3 / HDAC1 complex . ^^^ We discovered that the fusion partner ETO binds to the human homolog of the murine nuclear receptor corepressor ( N CoR ) . ^^^ Human N CoR ( HuN CoR ) , which we cloned and sequenced in its entirety , encodes a 2 , 440 amino acid polypeptide and has a central domain that binds ETO . ^^^ We found that ETO , through its interaction with the N CoR / mSin3 / HDAC1 complex , is also a potent repressor of transcription . ^^^ |
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| Interacting proteins: Q06455 and O75376 |
Pubmed |
SVM Score :0.0 |
| We report here that ETO ( eight twenty one or MTG 8 ) , which is fused to the acute myelogenous leukemia 1 ( AML 1 ) transcription factor in t ( 8 ; 21 ) AML , interacts via its zinc finger region with a conserved domain of the corepressors N CoR and SMRT and recruits HDAC in vivo . ^^^ The fusion protein AML 1 ETO retains the ability of ETO to form stable complexes with N CoR / SMRT and HDAC . ^^^ |
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| Interacting proteins: Q06455 and O75376 |
Pubmed |
SVM Score :0.0 |
| Association of PML RAR and AML 1 ETO with the nuclear corepressor ( N CoR ) / histone deacetylase ( HDAC ) complex is required to block hematopoietic differentiation . ^^^ Oligomerization requires PML or ETO coiled coil regions and is responsible for abnormal recruitment of N CoR , transcriptional repression , and impaired differentiation of primary hematopoietic precursors . ^^^ |
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| Interacting proteins: Q06455 and O75376 |
Pubmed |
SVM Score :0.0 |
| ETO interacts with nuclear receptor corepressors SMRT and N CoR , which recruit histone deacetylase to the AML 1 ETO oncoprotein . ^^^ SMRT N CoR interaction requires each of two zinc fingers contained in C terminal Nervy homology region 4 ( NHR 4 ) of ETO . ^^^ |
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| Interacting proteins: Q06455 and O75376 |
Pubmed |
SVM Score :0.0 |
| Here , we show that distinct domains of ETO contact the mSin3A and N CoR corepressors and define two binding sites within ETO for each of these corepressors . ^^^ Like ETO , ETO 2 interacts with N CoR , but ETO 2 fails to bind mSin3A . ^^^ |
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| Interacting proteins: Q06455 and O75376 |
Pubmed |
SVM Score :0.0 |
| ETO associates with the mSin 3 and N CoR co repressors as well as histone deacetylases 1 , 2 , and 3 . ^^^ |
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| Interacting proteins: Q06455 and O75376 |
Pubmed |
SVM Score :0.0 |
| The nuclear receptor co repressor ( N CoR ) utilizes repression domains 1 and 3 for interaction and co repression with ETO . ^^^ An analysis of ETO mediated repression revealed that one of the key binding partners of ETO is the nuclear receptor co repressor ( N CoR ) . ^^^ It is shown that two highly conserved domains of ETO interact with repression domains 1 and 3 of N CoR . ^^^ One of the ETO domains displays significant homology to Drosophila TAF ( 2 ) 110 , whereas the other is a predicted zinc binding motif that engages a conserved PPLXP motif in repression domain 3 of N CoR . ^^^ Together , these domains of ETO cooperate in repression with N CoR and the binding sites in N CoR overlap with those for other repressive factors . ^^^ |
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| Interacting proteins: Q06455 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06455 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06455 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06455 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06455 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
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