| Interacting proteins: O75376 and Q05516 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O75376 and Q05516 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O75376 and Q05516 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O75376 and Q05516 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O75376 and Q05516 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O75376 and Q05516 |
Pubmed |
SVM Score :0.0 |
| Here we show that both PML RARalpha and PLZF RARalpha fusion proteins recruit the nuclear co repressor ( N CoR ) histone deacetylase complex through the RARalpha CoR box . ^^^ Mutation of the N CoR binding site abolishes the ability of PML RARalpha to block differentiation , whereas inhibition of histone deacetylase activity switches the transcriptional and biological effects of PLZF RARalpha from being an inhibitor to an activator of the RA signalling pathway . ^^^ |
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| Interacting proteins: O75376 and Q05516 |
Pubmed |
SVM Score :0.0 |
| Although pharmacologic concentration of ATRA could still induce dissociation of N CoR from PML RARalpha , it had a very little effect on its association with the PLZF RARalpha fusion protein . ^^^ This ATRA insensitive interaction between N CoR and PLZF RARalpha was mediated by the N terminal PLZF moiety of the chimera . ^^^ It appears that N CoR / histone deacetylase corepressor complex interacts directly in an ATRA insensitive manner with the BTB / POZ domain of the wild type PLZF protein and is required , at least in part , for its function as a transcriptional repressor . ^^^ |
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| Interacting proteins: O75376 and Q05516 |
Pubmed |
SVM Score :0.0 |
| Rev erbAalpha / beta ) , Mxi 1 and Mad bHLH zip proteins and the oncoproteins PLZF and LAZ3 / BCL6 is mediated by the corepressors N CoR and SMRT . ^^^ |
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| Interacting proteins: O75376 and Q05516 |
Pubmed |
SVM Score :0.0 |
| We find , in vitro , that POZ domains from a variety of other POZ domain containing proteins , including the transcriptional repressor PLZF , as well as ZID , GAGA and a vaccinia virus protein , SalF17R , also interact with varying affinities with N CoR and SMRT . ^^^ |
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| Interacting proteins: O75376 and Q05516 |
Pubmed |
SVM Score :0.0 |
| Rev erbAalpha / beta ) , Mad / Max bHLH ( basic helix loop helix ) LZ proteins , and oncoproteins , PLZF and LAZ3 / BCL6 , bind DNA and silence transcription by recruiting a repressor complex that contains N CoR ( nuclear receptor corepressor ) / SMRT ( silencing mediator of retinoic acid and thyroid hormone receptor ) , Sin3A / B , and HDAc 1 / 2 proteins . ^^^ |
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| Interacting proteins: O75376 and Q05516 |
Pubmed |
SVM Score :0.0 |
| FAZF is homologous to the promyelocytic leukemia zinc finger ( PLZF ) protein , which has been shown to act as a transcriptional repressor by recruitment of nuclear corepressors ( N CoR , Sin 3 , and HDAC 1 complex ) . ^^^ |
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| Interacting proteins: O75376 and Q05516 |
Pubmed |
SVM Score :0.0 |
| In the human B cell lymphoma ( BCL 6 ) and promyelocityc leukemia ( PLZF ) oncoproteins , this domain mediates transcriptional repression through its ability to recruit a silencing mediator of retinoid and thyroid hormone receptor ( SMRT ) / nuclear receptor corepressor ( N CoR ) mSin3A histone deacetylase ( HDAC ) complex , a mechanism shared with numerous transcription factors . ^^^ However , in striking contrast with BCL 6 and PLZF , both HIC 1 and gammaFBP B similarly fail to interact with members of the HDAC complexes ( SMRT / N CoR , mSin3A or HDAC 1 ) in vivo and in vitro . ^^^ |
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| Interacting proteins: O75376 and Q05516 |
Pubmed |
SVM Score :0.0 |
| The N terminal portion of ETO forms complexes with PLZF , while the C terminal region , which was shown to bind to N CoR and SMRT , is required for the ability of ETO to augment transcriptional repression by PLZF . ^^^ |
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| Interacting proteins: O75376 and Q05516 |
Pubmed |
SVM Score :0.0 |
| We found that mutations of the BTB domain that neutralize key charged pocket residues did not disrupt dimerization , yet abrogated the ability of PLZF to repress transcription and led to the loss of interaction with N CoR , SMRT , and histone deacetylases ( HDACs ) . ^^^ |
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| Interacting proteins: O75376 and Q05516 |
Pubmed |
SVM Score :0.0 |
| Fusion protein of retinoic acid receptor alpha with promyelocytic leukemia protein or promyelocytic leukemia zinc finger protein recruits N CoR TBLR 1 corepressor complex to repress transcription in vivo . ^^^ |
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