| Interacting proteins: Q01196 and O75376 |
Pubmed |
SVM Score :0.0 |
| We report here that ETO ( eight twenty one or MTG 8 ) , which is fused to the acute myelogenous leukemia 1 ( AML 1 ) transcription factor in t ( 8 ; 21 ) AML , interacts via its zinc finger region with a conserved domain of the corepressors N CoR and SMRT and recruits HDAC in vivo . ^^^ The fusion protein AML 1 ETO retains the ability of ETO to form stable complexes with N CoR / SMRT and HDAC . ^^^ |
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| Interacting proteins: Q01196 and O75376 |
Pubmed |
SVM Score :0.0 |
| The resulting AML 1 ETO fusion is an aberrant transcriptional regulator due to the ability of ETO , which does not bind DNA itself , to recruit the transcriptional corepressors N CoR , SMRT , and Sin3A and histone deacetylases . ^^^ |
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| Interacting proteins: Q01196 and O75376 |
Pubmed |
SVM Score :0.0 |
| Association of PML RAR and AML 1 ETO with the nuclear corepressor ( N CoR ) / histone deacetylase ( HDAC ) complex is required to block hematopoietic differentiation . ^^^ |
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| Interacting proteins: Q01196 and O75376 |
Pubmed |
SVM Score :0.0 |
| Recruitment of the nuclear receptor corepressor N CoR by the TEL moiety of the childhood leukemia associated TEL AML 1 oncoprotein . ^^^ In contrast to the wild type AML 1 protein , both TEL and TEL AML 1 interact with N CoR , a component of the nuclear receptor corepressor complex with histone deacetylase activity . ^^^ The interaction between TEL and N CoR requires the central region of TEL , which is retained in TEL AML 1 , and TEL lacking this domain is impaired in transcriptional repression . ^^^ Taken together , our results suggest that TEL AML 1 may contribute to leukemogenesis by recruiting N CoR to AML 1 target genes and thus imposing an altered pattern of their expression . . ^^^ |
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| Interacting proteins: Q01196 and O75376 |
Pubmed |
SVM Score :0.0 |
| ETO interacts with nuclear receptor corepressors SMRT and N CoR , which recruit histone deacetylase to the AML 1 ETO oncoprotein . ^^^ |
|
| Interacting proteins: Q01196 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01196 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01196 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01196 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01196 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01196 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01196 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01196 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01196 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
|