| Interacting proteins: P41182 and O75376 |
Pubmed |
SVM Score :0.61178928 |
| Additionally , interactions between the BCL 6 POZ domain and SMRT , N CoR , and BCoR are mutually exclusive . 0.61178928^^^ |
|
| Interacting proteins: P41182 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41182 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41182 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41182 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41182 and O75376 |
Pubmed |
SVM Score :1.1439116 |
| Furthermore , when BCL 6 is bound to its consensus recognition sequence in vivo , it can interact with N CoR and SMRT . 1.1439116^^^ We find that BCL 6 POZ domain mutations that disrupt the interaction with N CoR and SMRT no longer repress transcription . 0.65856723^^^ |
|
| Interacting proteins: P41182 and O75376 |
Pubmed |
SVM Score :0.0 |
| In the human B cell lymphoma ( BCL 6 ) and promyelocityc leukemia ( PLZF ) oncoproteins , this domain mediates transcriptional repression through its ability to recruit a silencing mediator of retinoid and thyroid hormone receptor ( SMRT ) / nuclear receptor corepressor ( N CoR ) mSin3A histone deacetylase ( HDAC ) complex , a mechanism shared with numerous transcription factors . ^^^ However , in striking contrast with BCL 6 and PLZF , both HIC 1 and gammaFBP B similarly fail to interact with members of the HDAC complexes ( SMRT / N CoR , mSin3A or HDAC 1 ) in vivo and in vitro . ^^^ |
|
| Interacting proteins: P41182 and O75376 |
Pubmed |
SVM Score :0.0 |
| The homodimeric BTB domain of BCL 6 ( also known as the POZ domain ) is required for the repression activity of the protein and interacts directly with the SMRT and N CoR corepressors that are found within large multiprotein histone deacetylase containing complexes . ^^^ |
|