| Interacting proteins: O75376 and P29590 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75376 and P29590 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75376 and P29590 |
Pubmed |
SVM Score :0.0 |
| Here we show that both PML RARalpha and PLZF RARalpha fusion proteins recruit the nuclear co repressor ( N CoR ) histone deacetylase complex through the RARalpha CoR box . ^^^ Mutation of the N CoR binding site abolishes the ability of PML RARalpha to block differentiation , whereas inhibition of histone deacetylase activity switches the transcriptional and biological effects of PLZF RARalpha from being an inhibitor to an activator of the RA signalling pathway . ^^^ |
|
| Interacting proteins: O75376 and P29590 |
Pubmed |
SVM Score :0.0 |
| Although pharmacologic concentration of ATRA could still induce dissociation of N CoR from PML RARalpha , it had a very little effect on its association with the PLZF RARalpha fusion protein . ^^^ |
|
| Interacting proteins: O75376 and P29590 |
Pubmed |
SVM Score :0.0 |
| This chimeric protein has been strongly implicated in APL pathogenesis because of its interactions with growth suppressors ( PML ) , retinoid signaling molecules ( RXRalpha ) , and nuclear hormone transcriptional co repressors ( N CoR and SMRT ) . ^^^ |
|
| Interacting proteins: O75376 and P29590 |
Pubmed |
SVM Score :0.0 |
| Association of PML RAR and AML 1 ETO with the nuclear corepressor ( N CoR ) / histone deacetylase ( HDAC ) complex is required to block hematopoietic differentiation . ^^^ Oligomerization requires PML or ETO coiled coil regions and is responsible for abnormal recruitment of N CoR , transcriptional repression , and impaired differentiation of primary hematopoietic precursors . ^^^ |
|