| Interacting proteins: P12755 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P12755 and O75376 |
Pubmed |
SVM Score :0.80255789 |
| Recently , the c ski gene product ( c Ski ) was found to bind to N CoR ( nuclear hormone receptor co repressor ) , an element implicated in transcriptional repression mediated by multiple transcriptional repressors including the nuclear hormone receptors and Mad . c Ski is required for transcriptional repression mediated by Mad involved in negative regulation of cellular proliferation . 5 Ski abrogates Mad induced transcriptional repression in a dominant negative fashion . 0.80255789^^^ |
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| Interacting proteins: P12755 and O75376 |
Pubmed |
SVM Score :0.54693874 |
| Here we show that a nuclear oncoprotein , Ski , can interact directly with Smad 2 , Smad 3 , and Smad 4 on a TGFbeta responsive promoter element and repress their abilities to activate transcription through recruitment of the nuclear transcriptional corepressor N CoR and possibly its associated histone deacetylase complex . 0.54693874^^^ |
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| Interacting proteins: P12755 and O75376 |
Pubmed |
SVM Score :0.0 |
| Mutant Ski , lacking the N CoR binding , was no more capable of repressing RARalpha signaling . ^^^ |
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| Interacting proteins: P12755 and O75376 |
Pubmed |
SVM Score :0.0 |
| Here , we report that MeCP 2 directly binds to two co repressors , c Ski and N CoR , in addition to mSin3A , and that the c Ski , which is encoded by the c ski proto onocogene , is required for MeCP 2 mediated transcriptional repression . ^^^ |
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| Interacting proteins: P12755 and O75376 |
Pubmed |
SVM Score :0.0 |
| Signal dependent N CoR requirement for repression by the Ski oncoprotein . ^^^ To achieve this , Ski has been proposed to recruit the corepressor N CoR to either the TGF beta regulated Smad transcription factors or nuclear receptors . ^^^ Here we define the role of the Ski / N CoR interaction in Ski mediated repression of TGF beta and vitamin D signaling . ^^^ More importantly , a Ski single point mutant lacking N CoR binding revealed that the Ski / N CoR interaction is essential for repression of vitamin D signaling , but , surprisingly , not TGF beta signaling . ^^^ Thus , Ski modulates transcription in either an N CoR dependent or independent manner depending on the signaling pathways targeted . . ^^^ |
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