| Interacting proteins: P10276 and O75376 |
Pubmed |
SVM Score :0.68975171 |
| A 57 amino acid portion of N CoR containing the LDNLL sequence ( N CoR ( LDNLL ) ) fused to GST interacted with retinoic acid receptor alpha ( RARalpha ) and thyroid hormone receptor beta ( TRbeta ) in vitro . 0.68975171^^^ |
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| Interacting proteins: P10276 and O75376 |
Pubmed |
SVM Score :0.65332885 |
| We first show that the endogenous corepressor N CoR forms a complex with TBLR 1 ( transducin beta like protein 1 related protein ) and that both N CoR and TBLR 1 can interact with unliganded PML RARalpha and PLZF RARalpha in vivo . 0.65332885^^^ |
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| Interacting proteins: P10276 and O75376 |
Pubmed |
SVM Score :0.0 |
| Cell specific inhibition of retinoic acid receptor alpha silencing by the AF2 / tau c activation domain can be overcome by the corepressor SMRT , but not by N CoR . ^^^ |
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| Interacting proteins: P10276 and O75376 |
Pubmed |
SVM Score :0.0 |
| Investigating the mechanism underlying the effects of these drugs on ATRA induced APL cell differentiation , we have shown that benzodithiophenes enhance ATRA mediated dissociation and association of corepressor N CoR and coactivator p 300 acetyltransferase , respectively , with retinoic acid receptor ( RAR ) alpha proteins . ^^^ |
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| Interacting proteins: P10276 and O75376 |
Pubmed |
SVM Score :0.0 |
| We recently reported the presence of an LXXLL motif in N CoR , and showed that this motif interacts in vitro and in vivo with retinoic acid receptor alpha ( RARalpha ) and thyroid hormone receptor beta ( TRbeta ) . ^^^ |
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| Interacting proteins: P10276 and O75376 |
Pubmed |
SVM Score :0.0 |
| Here we show that ligand dependent transactivation by RAR on DR + 5 elements requires the dissociation of a new nuclear receptor co repressor , N CoR , and recruitment of the putative co activators p 140 and p 160 . ^^^ Surprisingly , on DR + 1 elements , N CoR remains associated with RAR / RXR heterodimers even in the presence of RAR ligands , resulting in constitutive repression . ^^^ |
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| Interacting proteins: P10276 and O75376 |
Pubmed |
SVM Score :0.0 |
| An interaction screen with the repression domain of the orphan receptor RevErb identified N CoR , the corepressor for thyroid hormone receptor ( TR ) and retinoic acid receptor ( RAR ) . ^^^ Remarkably , a region homologous to the CoR box which is necessary for TR and RAR to interact with N CoR is not required for RevErb . ^^^ The primary amino acid sequence of the N terminal region of RevErb essential for N CoR interaction is not homologous to that of TR or RAR , whereas similarities exist among the C terminal domains of the receptors . ^^^ |
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| Interacting proteins: P10276 and O75376 |
Pubmed |
SVM Score :0.0 |
| Detailed analysis of the interaction with TR and RAR demonstrates that RIP13 / N CoR contains a new receptor interaction domain , termed ID 2 , in addition to the previously described domain , referred to here as ID 1 . ^^^ Results with all three approaches confirm that RIP13 / N CoR also interacts with retinoid 10 receptor , but this interaction is weaker than that with TR or RAR . ^^^ |
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| Interacting proteins: P10276 and O75376 |
Pubmed |
SVM Score :0.0 |
| In contrast to RAR , which prevents the binding of RXR ligands and recruits the nuclear receptor corepressor N CoR , PPAR permits the binding of SRC 1 in response to both RXR and PPAR ligands . ^^^ |
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| Interacting proteins: P10276 and O75376 |
Pubmed |
SVM Score :0.0 |
| Similarly , co repressors , such as SMRT and N CoR , for TR and retinoic acid receptors ( RAR ) have been identified . ^^^ |
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| Interacting proteins: P10276 and O75376 |
Pubmed |
SVM Score :0.0 |
| TR and RAR can similarly interact with the corepressor proteins , and the cotransfected nuclear receptor corepressor ( N CoR ) has been demonstrated to augment the transcriptional stimulation of the TRH gene by unliganded TR . ^^^ As observed with TR , the coexpression of a N CoR variant significantly enhanced the ligand independent stimulation by RAR . ^^^ The constitutive stimulation by RAR 403 was augmented by the cotransfected N CoR variant . ^^^ |
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| Interacting proteins: P10276 and O75376 |
Pubmed |
SVM Score :0.0 |
| Detection of nuclear receptor corepressor ( N CoR ) association with RARgamma was greatly facilitated by inclusion of a RARE oligonucleotide in coimmunoprecipitation analyses , a result of an increase in association of the ternary complex consisting of RAR , RXR , and DNA . ^^^ |
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| Interacting proteins: P10276 and O75376 |
Pubmed |
SVM Score :0.0 |
| Association of PML RAR and AML 1 ETO with the nuclear corepressor ( N CoR ) / histone deacetylase ( HDAC ) complex is required to block hematopoietic differentiation . ^^^ |
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| Interacting proteins: P10276 and O75376 |
Pubmed |
SVM Score :0.0 |
| This induction is attenuated by the histone deacetylase inhibitor , trichostatin A , and by coexpression of a dominant negative nuclear receptor corepressor 1 , indicating an unexpected requirement for RAR mediated repression in skeletal progenitor differentiation . ^^^ |
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| Interacting proteins: P10276 and O75376 |
Pubmed |
SVM Score :0.0 |
| METHODS : Multiprobe ribonuclease protection assay and real time reverse transcriptase polymerase chain reaction were used to quantitate mRNA levels of steroid receptors , vitamin D receptor ( VDR ) , retinoic acid receptors ( RAR ) , and cofactors AIB 1 ( amplified in breast cancer 1 ) , CBP ( cyclic adenosine monophosphate response element binding protein ) , pCAF ( p300 / CBP associated factor ) , TIF 2 ( transcription intermediary factor 2 ) , N CoR ( nuclear receptor corepressor ) , and SMRT ( silencing mediator of repressed transcription ) . ^^^ |
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| Interacting proteins: P10276 and O75376 |
Pubmed |
SVM Score :0.0 |
| Here we show that both PML RARalpha and PLZF RARalpha fusion proteins recruit the nuclear co repressor ( N CoR ) histone deacetylase complex through the RARalpha CoR box . ^^^ Mutation of the N CoR binding site abolishes the ability of PML RARalpha to block differentiation , whereas inhibition of histone deacetylase activity switches the transcriptional and biological effects of PLZF RARalpha from being an inhibitor to an activator of the RA signalling pathway . ^^^ |
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| Interacting proteins: P10276 and O75376 |
Pubmed |
SVM Score :0.0 |
| We now show that the above mentioned oncogenic fusion proteins interact with the nuclear receptor corepressor N CoR and , in comparison with the wild type RARalpha protein , their interactions display reduced sensitivities to ATRA . ^^^ Although pharmacologic concentration of ATRA could still induce dissociation of N CoR from PML RARalpha , it had a very little effect on its association with the PLZF RARalpha fusion protein . ^^^ This ATRA insensitive interaction between N CoR and PLZF RARalpha was mediated by the N terminal PLZF moiety of the chimera . ^^^ |
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| Interacting proteins: P10276 and O75376 |
Pubmed |
SVM Score :0.0 |
| The aim of the study was to test the hypothesis that expression of retinoid receptors ( RARalpha , RARbeta , RARgamma ) , rexinoid receptors ( RXRalpha , RXRbeta ) , thyroid hormone receptors ( TRalpha , TRbeta ) , estrogen receptors ( ERalpha , ERbeta ) , nuclear receptor coregulators ( N CoR , SRC 1 , SMRT ) , and in addition type 1 iodothyronine 5 ' deiodinase ( 5 ' DI ) , EGFR and erb B2 / neu would be different in mammary postlactating tissue in comparison with that of nonlactating mammary gland . ^^^ Using RT PCR , we have shown that expression of RARalpha , RXRalpha , TRalpha , ERalpha , ERbeta , N CoR , SRC 1 , SMRT and EGFR in rat was significantly increased in postlactating mammary gland when compared to that of nonlactating mammary tissue . ^^^ |
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| Interacting proteins: P10276 and O75376 |
Pubmed |
SVM Score :0.0 |
| Mutant Ski , lacking the N CoR binding , was no more capable of repressing RARalpha signaling . ^^^ |
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| Interacting proteins: P10276 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10276 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10276 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10276 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10276 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10276 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10276 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10276 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10276 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10276 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10276 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10276 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
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