| Interacting proteins: O75376 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O75376 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O75376 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O75376 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O75376 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O75376 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O75376 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O75376 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O75376 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O75376 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O75376 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O75376 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O75376 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O75376 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O75376 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O75376 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O75376 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O75376 and P10275 |
Pubmed |
SVM Score :0.0 |
| Moreover , a transcriptional corepressor N CoR additively decreased the transcriptional activity of AR with TZF . ^^^ |
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| Interacting proteins: O75376 and P10275 |
Pubmed |
SVM Score :0.0 |
| The AR acetylation site mutant showed 10 fold increased binding of the N CoR corepressor compared with the AR wild type in the presence of ligand . ^^^ As AR lysine residue mutations that abrogate acetylation correlate with enhanced binding of the N CoR repressor in cultured cells , the conserved AR motif may directly or indirectly regulate ligand dependent corepressor disengagement and , thereby , ligand dependent trans activation . . ^^^ |
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| Interacting proteins: O75376 and P10275 |
Pubmed |
SVM Score :0.0 |
| The androgen receptor recruits nuclear receptor CoRepressor ( N CoR ) in the presence of mifepristone via its N and C termini revealing a novel molecular mechanism for androgen receptor antagonists . ^^^ |
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| Interacting proteins: O75376 and P10275 |
Pubmed |
SVM Score :0.0 |
| On the other hand , although overexpression of corepressors N CoR and SMRT could result in evident inhibition on DHT or CPA induced transactivity of wtAR and the AR mutants , N CoR displayed stronger inhibitory effects on DHT induced transactivity of the AR mutants ( especially for E872Q and M886I ) than that of wtAR . ^^^ |
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| Interacting proteins: O75376 and P10275 |
Pubmed |
SVM Score :0.0 |
| We have investigated the role of corepressors SMRT ( silencing mediator of retinoid and thyroid hormone receptor ) and N CoR ( nuclear receptor corepressor ) in transcriptional regulation by androgen receptor ( AR ) in the LNCaP prostate cancer cell line . ^^^ Using specific small interference RNAs to knock down SMRT and / or N CoR in LNCaP cells , we found that SMRT and N CoR not only mediate antagonist dependent inhibition of AR activation but also have a widespread role in suppressing agonist dependent activation of several AR target genes we have tested , including PSA ( prostate specific antigen ) , TSC 22 ( TSC 22 domain family member 1 ) , NKX 3 1 ( NK 3 transcription factor locus 1 ) , and B2M ( beta 2 microglobulin ) . ^^^ Consistent with a role in both antagonist and agonist regulated transcription by AR , chromatin immunoprecipitation analysis revealed that both SMRT and N CoR were recruited by AR to these genes in the presence of either flutamide or R 1881 . ^^^ Knocking down SMRT and N CoR enhanced the recruitment of the coactivators steroid receptor coactivator 1 and p 300 by agonist bound AR and led to increased hyperacetylation of histone H 3 and H 4 , suggesting that the corepressors actively compete with coactivators for binding to agonist bound AR . ^^^ Taken together , our data indicate that SMRT and N CoR corepressors are involved in transcriptional regulation by both agonist and antagonist bound AR and regulate the magnitude of hormone response , at least in part , by competing with coactivators . . ^^^ |
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| Interacting proteins: O75376 and P10275 |
Pubmed |
SVM Score :0.0 |
| Although initially responsive to selective androgen receptor modulators ( SARMs ) , which cause recruitment of the nuclear receptor corepressor ( N CoR ) complex , resistance invariably occurs , perhaps in response to inflammatory signals . ^^^ |
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| Interacting proteins: O75376 and P10275 |
Pubmed |
SVM Score :0.0 |
| Yellow fluorescent protein ( YFP ) N CoR was distributed as intranuclear discrete dots , while coexpression of androgen receptor ( AR ) , glucocorticoid receptor alpha , and estrogen receptor alpha ligand dependently triggered redistribution of YFP N CoR . ^^^ In fluorescence recovery after photobleaching analysis , mobility of the N CoR was reduced by 5alpha dihydrotestosterone ( DHT ) bound AR . ^^^ N CoR impaired the DHT induced N C interaction of AR , and the impaired interaction was dose dependently recovered by coexpression of SRC 1 and CBP . ^^^ Coexpression of SRC 1 or CBP released YFP N CoR or endogenous N CoR from incomplete foci and simultaneously recovered complete foci of AR green fluorescent protein . ^^^ |
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| Interacting proteins: O75376 and P10275 |
Pubmed |
SVM Score :0.0 |
| EXPERIMENTAL DESIGN : The expression of 16 AR coactivators and corepressors ( SRC 1 , beta catenin , TIF 2 , PIAS 1 , PIASx , ARIP 4 , BRCA 1 , AIB 1 , AIB 3 , CBP , STAT 1 , NCoR 1 , AES , cyclin D 1 , p 300 , and ARA 24 ) was measured in prostate cancer cell lines , xenografts , and clinical prostate tumor specimens by using real time quantitative reverse transcription PCR . ^^^ |
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