| Interacting proteins: O75367 and O43791 |
Pubmed |
SVM Score :0.0 |
| Stable 10 chromosome inactivation involves the PRC 1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3 / SPOP ubiquitin E 3 ligase . 10 inactivation involves the stable silencing of one of the two 10 chromosomes in 20 female mammals . ^^^ |
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| Interacting proteins: O75367 and O43791 |
Pubmed |
SVM Score :0.0 |
| MacroH2A1 . 2 binds the nuclear protein Spop . 10 chromosome inactivation is a phenomenon by which one of the two 10 chromosomes in somatic cells of female mammals is inactivated for life . ^^^ The results showed that macroH2A1 . 2 interacts with mouse nuclear speckled type protein Spop . ^^^ Further binding domain mapping in a glutathione S transferase ( GST ) pull down experiment revealed that macroH2A1 . 2 binds the MATH domain of Spop , which in turn binds to the putative leucine zipper domain of macroH2A1 . 2 . . ^^^ |
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