| Interacting proteins: O75330 and P16070 |
Pubmed |
SVM Score :0.0 |
| We show that two HA receptors , RHAMM ( receptor for hyaluronan mediated motility ) and CD 44 , are present on these ras transformed fibroblasts . ^^^ |
|
| Interacting proteins: O75330 and P16070 |
Pubmed |
SVM Score :0.0 |
| Hyaluronan dependent motility of B cells and leukemic plasma cells in blood , but not of bone marrow plasma cells , in multiple myeloma : alternate use of receptor for hyaluronan mediated motility ( RHAMM ) and CD 44 . ^^^ |
|
| Interacting proteins: O75330 and P16070 |
Pubmed |
SVM Score :0.0 |
| Immunofluorescent cytochemistry was carried on HRPE 7 and F 2000 cells for the HA receptors , homing receptor CD 44 ( CD 44 ) , intercellular adhesion molecule 1 ( ICAM 1 ) , and the receptor for hyaluronan mediated motility ( RHAMM ) . ^^^ |
|
| Interacting proteins: O75330 and P16070 |
Pubmed |
SVM Score :0.0 |
| Receptor for hyaluronan mediated motility and CD 44 expressions in colon cancer assessed by quantitative analysis using real time reverse transcriptase polymerase chain reaction . ^^^ |
|
| Interacting proteins: O75330 and P16070 |
Pubmed |
SVM Score :0.0 |
| The CD 44 glycoprotein is expressed in multiple isoforms on a variety of cell types where it functions as a receptor for hyaluronan mediated motility . ^^^ |
|
| Interacting proteins: O75330 and P16070 |
Pubmed |
SVM Score :0.0 |
| Interestingly , sHA induced DC maturation does not involve the HA receptors CD 44 or the receptor for hyaluronan mediated motility , because DC from CD 44 deficient mice and wild type mice both responded similarly to sHA stimulation , whereas the receptor for hyaluronan mediated motility is not detectable in DC . ^^^ |
|
| Interacting proteins: O75330 and P16070 |
Pubmed |
SVM Score :0.0 |
| For the identification of surface receptor ( s ) mediating PMN migration on HA , PMN were incubated with blocking and non blocking antibodies against cluster of differentiation 44 ( CD 44 ) and Receptor for Hyaluronan Mediated Motility ( RHAMM ) prior to addition to HA coated surfaces . ^^^ |
|
| Interacting proteins: O75330 and P16070 |
Pubmed |
SVM Score :0.0 |
| A number of hyaluronan ( HA ) binding proteins such as soluble CD 44 , receptor for hyaluronan mediated motility ( RHAMM ) , and metastatin inhibit tumor growth and metastasis . ^^^ |
|
| Interacting proteins: O75330 and P16070 |
Pubmed |
SVM Score :0.0 |
| RHAMM , a receptor for hyaluronan mediated motility , compensates for CD 44 in inflamed CD 44 knockout mice : a different interpretation of redundancy . ^^^ Furthermore , we show that under the inflammatory cascade , RHAMM ( receptor for hyaluronan mediated motility ) , a hyaluronan receptor distinct from CD 44 , compensates for the loss of CD 44 in binding hyaluronic acid , supporting cell migration , up regulating genes involved with inflammation ( as assessed by microarrays containing 13 , 000 cDNA clones ) , and exacerbating collagen induced arthritis . ^^^ |
|
| Interacting proteins: O75330 and P16070 |
Pubmed |
SVM Score :0.0 |
| Our results further demonstrate that both CD 44 and receptor for hyaluronan mediated motility ( RHAMM ) are involved in binding cell surface associated HA on Hfob cells . ^^^ |
|
| Interacting proteins: O75330 and P16070 |
Pubmed |
SVM Score :0.0 |
| The hyaladherins , receptor for hyaluronan mediated motility and CD 44 were also increased after stroke . ^^^ |
|
| Interacting proteins: O75330 and P16070 |
Pubmed |
SVM Score :0.0 |
| Identification of a common hyaluronan binding motif in the hyaluronan binding proteins RHAMM , CD 44 and link protein . ^^^ Recombinant techniques were used to generate chimeric proteins containing either the B ( X 7 ) B motifs present in CD 44 or link protein , with the amino terminus of RHAMM ( amino acids 1 238 ) that does not bind HA . ^^^ Collectively , these results predict that the motif of B ( X 7 ) B as a minimal binding requirement for HA in RHAMM , CD 44 and link protein , and occurs in all HA binding proteins described to date . . ^^^ |
|
| Interacting proteins: O75330 and P16070 |
Pubmed |
SVM Score :0.0 |
| The cDNAs coding for two families of such proteins , CD 44 and RHAMM , have been cloned and characterized . ^^^ |
|
| Interacting proteins: O75330 and P16070 |
Pubmed |
SVM Score :0.0 |
| Although all the lung tumor cell lines expressed various amounts of CD 44 and RHAMM , only the SCLC line U 1752 could bind [ 3H ] hyaluronan . ^^^ |
|
| Interacting proteins: O75330 and P16070 |
Pubmed |
SVM Score :0.0 |
| Many of the effects of HA are mediated through cell surface receptors , three of which have been molecularly characterized , namely CD 44 , RHAMM , and ICAM 1 . ^^^ |
|
| Interacting proteins: O75330 and P16070 |
Pubmed |
SVM Score :0.0 |
| In rabbits , stenosis following balloon angioplasty is prevented by a subcutaneous dose of HA , probably through blockade of cell surface HA receptors ( ICAM 1 , CD 44 & RHAMM ) . ^^^ |
|
| Interacting proteins: O75330 and P16070 |
Pubmed |
SVM Score :0.0 |
| Cellular receptors for hyaluronan such as CD 44 and RHAMM ( receptor for hyaluronate mediated motility ) have also been identified . ^^^ |
|
| Interacting proteins: O75330 and P16070 |
Pubmed |
SVM Score :0.0 |
| In addition to contributing to the unique structure of the pericellular matrix , hyaluronan interacts with cell surface receptors , such as RHAMM and CD 44 . ^^^ Thirdly , in vitro studies suggest strongly that interactions of hyaluronan with RHAMM or CD 44 are involved in cell movement and proliferation , which are critical events in morphogenesis . . ^^^ |
|
| Interacting proteins: O75330 and P16070 |
Pubmed |
SVM Score :0.0 |
| Cancer cells exhibit binding sites ( CD 44 , RHAMM ) for HYA . ^^^ |
|
| Interacting proteins: O75330 and P16070 |
Pubmed |
SVM Score :0.0 |
| Nor could ligands for scavenger receptors and antibodies directed towards ICAM 1 , CD 44 and RHAMM ( Receptor for HA Mediated Motility ) significantly inhibit the association of HA to tumour cells . . ^^^ |
|
| Interacting proteins: O75330 and P16070 |
Pubmed |
SVM Score :0.0 |
| Of these three HABPs , CD 44 was associated with the articular fibrocartilages and interzone , whereas RHAMM and the IVd 4 epitope were associated with all three tissues . ^^^ |
|
| Interacting proteins: O75330 and P16070 |
Pubmed |
SVM Score :0.0 |
| Three of them , CD 44 , ICAM 1 and RHAMM ( receptor for hyaluronic acid mediated motility ) , have been identified . ^^^ |
|
| Interacting proteins: O75330 and P16070 |
Pubmed |
SVM Score :0.0 |
| Because expression of the HA receptors , CD 44 and RHAMM ( Receptor for HA Mediated Motility ) , has been associated with adult wound fibroplasia , the authors postulated that fetal excisional wounds would show increased expression of CD 44 and RHAMM as compared with incisional wounds . ^^^ CD 44 and RHAMM expression were analyzed by immunohistochemistry and immunoblotting . ^^^ Between 1 and 7 days in either human or sheep fetal wounds , immunostaining for CD 44 and RHAMM markedly increased along the margins of excisional wounds as compared with incisional wounds and unwounded skin . ^^^ |
|
| Interacting proteins: O75330 and P16070 |
Pubmed |
SVM Score :0.0 |
| We determined whether Mo that had invaded sites of cutaneous inflammation bind HA and express the putative HA receptors CD 44 isoforms , ICAM 1 , or receptor for hyaluronate mediated motility ( RHAMM ) . ^^^ In cutaneous inflammation , activated infiltrating Mo displayed high HA avidity and expressed epitopes encoded by CD44s , CD 44 variant exons v 3 , v 4 , v 5 , v 6 , v 7 , and v 9 , and ICAM 1 , but not RHAMM . ^^^ |
|
| Interacting proteins: O75330 and P16070 |
Pubmed |
SVM Score :0.0 |
| Differential expression of the hyaluronan receptors CD 44 and RHAMM in human pancreatic cancer cells . ^^^ These results indicate that CD 44 and RHAMM differentially contribute to invasion of pancreatic adenocarcinoma ; however , these functions still remain to be determined . . ^^^ |
|
| Interacting proteins: O75330 and P16070 |
Pubmed |
SVM Score :0.0 |
| Hyaluronate and its receptors ( CD 44 and RHAMM or receptor for HA mediated motility ) contribute actively to leukocyte adhesion and infiltration at experimental angioplasty sites . ^^^ Studies of cell cultures have shown that leukocyte adhesion and migration are inhibited by substances ( antibodies , peptides , high levels of hyaluronate ) that prevent hyaluronate from binding to CD 44 and RHAMM . ^^^ The SMCs that migrate and divide actively at the arterial lesion site are those that express hyaluronate , CD 44 , and RHAMM . ^^^ Hyaluronate both stimulates SMC migration via an effect on RHAMM and enhances SMC division via an effect on CD 44 . ^^^ |
|
| Interacting proteins: O75330 and P16070 |
Pubmed |
SVM Score :0.0 |
| Video time lapse microscopy indicates that a subset of thymocytes also undergo spontaneous Fn dependent motility mediated by alpha5beta1 , alpha4beta1 , and the HA receptor RHAMM , but not by CD 44 . ^^^ |
|
| Interacting proteins: O75330 and P16070 |
Pubmed |
SVM Score :0.0 |
| Blocking antibodies showed that this motility is mediated by the receptor for HA mediated motility ( RHAMM ) , without the involvement of CD 44 . ^^^ Moreover , confocal microscopy showed a polarized distribution of RHAMM and F actin , but not CD 44 , in cells which had become motile on HA in the presence of IL 8 . ^^^ |
|
| Interacting proteins: O75330 and P16070 |
Pubmed |
SVM Score :0.0 |
| RHAMM , not CD 44 , bound HA in all three ECs . ^^^ |
|
| Interacting proteins: O75330 and P16070 |
Pubmed |
SVM Score :0.0 |
| Expression of hyaluronan receptors CD 44 and RHAMM in stomach cancers : relevance with tumor progression . ^^^ Interactions of hyaluronic acid ( HA ) with its binding proteins CD 44 and RHAMM ( receptor for HA mediating motility ) have been proposed to be important in promoting tumor progression and dissemination . ^^^ Expression of CD 44 and RHAMM may benefit the invasion and metastasis of gastric cancer cells presumably in a reciprocal manner . . ^^^ |
|
| Interacting proteins: O75330 and P16070 |
Pubmed |
SVM Score :0.0 |
| Animal lectins are recognized as molecules playing important roles in a variety of biological processes through binding to glycoconjugates and lectin like receptors such as selectins , sialoadhesins ( CD 22 , CD 33 ) , natural killer receptors ( NKR P 1 , CD 69 and CD94 / NKG2 ) , hyaluronate receptors ( CD 44 , RHAMM , ICAM 1 ) , B cell associated antigen ( CD 23 , CD 72 ) , beta 2 leukocyte integrin ( CD11b / CD18 ) or the well known receptors for mannose , mannose 6 phosphate or asialoglycoprotein have been suggested to be able to mediate the transfer of information from the outside to the inside of the cell . ^^^ |
|
| Interacting proteins: O75330 and P16070 |
Pubmed |
SVM Score :0.0 |
| The role of CD 44 was specific , because inhibiting receptor for hyaluronic acid mediated motility ( RHAMM ) had no effect . ^^^ |
|
| Interacting proteins: O75330 and P16070 |
Pubmed |
SVM Score :0.0 |
| CD 34 ( + ) 45 ( lo / med ) Scatterlo / med HPCs from granulocyte colony stimulating factor ( G CSF ) mobilized blood and mobilized BM were compared with steady state BM for their ability to bind hyaluronan ( HA ) , their expression of the HA receptors RHAMM and CD 44 , and their motogenic behavior . ^^^ Although RHAMM and CD 44 are expressed by mobilized blood HPCs , function blocking monoclonal antibodies ( MoAbs ) identified RHAMM as a major HA binding receptor , with a less consistent participation by CD 44 . ^^^ Also , in contrast to mobilized blood HPCs , for steady state BM HPCs , MoAbs to RHAMM and CD 44 act as agonists to upregulate HA binding . ^^^ Thus , G CSF mobilization may stimulate an autocrine stimulatory loop for HPCs in which HA interacts with basal levels of RHAMM and / or CD 44 to stimulate receptor recycling . ^^^ HPC adherence was inhibited by MoAbs to beta 1 integrin and CD 44 , but not to RHAMM , whereas HPC motility was inhibited by MoAb to RHAMM and beta 1 integrin , but not to CD 44 . ^^^ |
|
| Interacting proteins: O75330 and P16070 |
Pubmed |
SVM Score :0.0 |
| Differential expression patterns of hyaluronan receptors CD 44 and RHAMM in transitional cell carcinomas of urinary bladder . ^^^ The interactions of hyaluronic acid ( HA ) and its receptors , CD 44 and RHAMM , on cancer cells can promote invasion and metastasis but parallel study on these two genes in TCCs has not been available . ^^^ Our data further confirm the promising prognostic value of CD 44 for TCC patients and demonstrate , for the first time , the correlation between RHAMM expression and malignant transformation of urothelial cells . . ^^^ |
|
| Interacting proteins: O75330 and P16070 |
Pubmed |
SVM Score :0.0 |
| The objective of the present study was to quantify mRNA transcripts of the HA synthase ( HAS ) 1 , HAS 2 , and HAS 3 and the HA receptors CD 44 and RHAMM ( receptor for HA mediated motility ) . ^^^ Expression of CD 44 mRNA greatly increased during in vitro maturation of COCs , indicating an important role when compared to an unchanged , steady state RHAMM expression . ^^^ |
|
| Interacting proteins: O75330 and P16070 |
Pubmed |
SVM Score :0.0 |
| The frequent overexpression of the hyaluronan receptors CD 44 and RHAMM in cancer cells opens the door for targeting by the naturally occurring high M ( r ) hyaluronan . ^^^ |
|
| Interacting proteins: O75330 and P16070 |
Pubmed |
SVM Score :0.0 |
| It appears to exert its biological effects through binding interactions with at least two cell surface receptors : CD 44 and receptor for HA mediated motility ( RHAMM ) . ^^^ We therefore investigated the endothelial expression of these proteins and determined the effects of antibodies against RHAMM and CD 44 on endothelial cell ( EC ) function and in vivo angiogenesis . ^^^ Further studies with active blocking antibodies revealed that anti CD 44 but not anti RHAMM antibody inhibited EC adhesion to HA and EC proliferation , whereas anti RHAMM but not CD 44 antibody blocked EC migration through the basement membrane substrate , Matrigel . ^^^ These data suggest that RHAMM and CD 44 , through interactions with their ligands , are both important to processes required for the formation of new blood vessels . . ^^^ |
|
| Interacting proteins: O75330 and P16070 |
Pubmed |
SVM Score :0.0 |
| Ubiquitous receptors for HA are CD 44 and the Receptor for HA Mediated Motility known as RHAMM . ^^^ In the present study , we have investigated the potential role of CD 44 and RHAMM in the migration and proliferation of human astrocytoma cells . ^^^ The effects of HA , CD 44 blocking antibodies , and RHAMM soluble peptide on astrocytoma cell growth and migration was determined using MTT and migration assays . ^^^ Our results show that the expression of the HA receptors , CD 44 , and RHAMM , is virtually ubiquitous amongst glioma cell lines , and glioma tumor specimens . ^^^ There was a gradient of expression amongst gliomas with high grade gliomas expressing more RHAMM and CD 44 than did lower grade lesions or did normal human astrocytes or non neoplastic specimens of human brain . ^^^ |
|
| Interacting proteins: O75330 and P16070 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To explore the potential significance of expression of CD 44 and RHAMM at different stages of gastric carcinogenesis . ^^^ METHODS : The expression pattern of CD 44 and RHAMM in non cancerous mucosa , preneoplastic lesions and carcinomas of the stomach was examined by RT PCR , Southern blot hybridization , immunohistochemical staining and Western blot hybridization . ^^^ |
|
| Interacting proteins: O75330 and P16070 |
Pubmed |
SVM Score :0.0 |
| In this study , the regulation and localization of HA , its synthases ( HAS 1 3 ) and the receptors CD 44 , RHAMM , and putative HARE were investigated in bovine oviducts during the estrous cycle . ^^^ |
|
| Interacting proteins: O75330 and P16070 |
Pubmed |
SVM Score :0.0 |
| This data is consistent with regulatory influences secondary to HA binding to CD 44 and / or RHAMM cell surface receptors , both of which were shown to be expressed on U 937 macrophages . ^^^ |
|
| Interacting proteins: O75330 and P16070 |
Pubmed |
SVM Score :0.0 |
| The synthesis and degradation rates of hyaluronan were determined by ELISA , while quantitation of HA receptors , CD 44 and RHAMM was performed by comparative Western blotting . ^^^ |
|
| Interacting proteins: O75330 and P16070 |
Pubmed |
SVM Score :0.0 |
| Moreover , HA interacts with proteins such as CD 44 , RHAMM , and fibrinogen , thereby influencing many natural processes such as angiogenesis , cancer , cell motility , wound healing , and cell adhesion . ^^^ |
|
| Interacting proteins: O75330 and P16070 |
Pubmed |
SVM Score :0.0 |
| To see whether HA might link PNNs to the neuronal cell surface by binding to a receptor , we investigated the expression of the HA receptors CD 44 , RHAMM , and LYVE 1 . ^^^ |
|
| Interacting proteins: O75330 and P16070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75330 and P16070 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75330 and P16070 |
Pubmed |
SVM Score :0.0 |
| NA |
|