| Interacting proteins: O75081 and Q06455 |
Pubmed |
SVM Score :0.60420957 |
| Similarly , the chimeric oncoprotein AML 1 ETO interacted with both MTGR 1 and MTG 16 . 0.60420957^^^ |
|
| Interacting proteins: O75081 and Q06455 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75081 and Q06455 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75081 and Q06455 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75081 and Q06455 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75081 and Q06455 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75081 and Q06455 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75081 and Q06455 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75081 and Q06455 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75081 and Q06455 |
Pubmed |
SVM Score :0.0 |
| We characterize two human MTG 8 related genes , MTGR 1 and MTGR 2 ( HGMW approved symbols CBFA2T2 and CBFA2T3 ) . ^^^ |
|
| Interacting proteins: O75081 and Q06455 |
Pubmed |
SVM Score :0.0 |
| The genomic structure of MTGR 1 is highly similar to those of other MTG 8 family genes , MTG 8 and MTG 16 . ^^^ |
|
| Interacting proteins: O75081 and Q06455 |
Pubmed |
SVM Score :0.0 |
| The transcriptional repression of growth factor independent 1 ( GFI 1 ) , a previously characterized ETO effector zinc finger protein , was shown to be enhanced by CBFA2T1 , but to a lesser extent by CBFA2T2 and CBFA2T3 . ^^^ |
|
| Interacting proteins: O75081 and Q06455 |
Pubmed |
SVM Score :0.0 |
| ETO 2 , a new member of the ETO family of nuclear proteins . ^^^ Here we describe the isolation and characterization of ETO 2 , a murine cDNA that encodes a new member of the ETO family of proteins . ^^^ ETO 2 is 75 % identical to murine ETO and shares very high sequence identities over four regions of the protein with ETO ( domain 1 3 and zinc finger ) . ^^^ Northern analysis identifies ETO 2 transcripts in many of the murine tissues analysed and in the developing mouse embryo . ^^^ ETO 2 is also expressed in myeloid and erythroid cell lines . ^^^ |
|
| Interacting proteins: O75081 and Q06455 |
Pubmed |
SVM Score :0.0 |
| We also show that the murine homologue of MTG 16 , ETO 2 , is also a transcriptional corepressor that works through a similar but distinct mechanism . ^^^ Like ETO , ETO 2 interacts with N CoR , but ETO 2 fails to bind mSin3A . ^^^ Furthermore , ETO 2 binds HDAC 1 , HDAC 2 , and HDAC 3 but also interacts with HDAC 6 and HDAC 8 . ^^^ |
|
| Interacting proteins: O75081 and Q06455 |
Pubmed |
SVM Score :0.0 |
| The structural analysis of the cDNAs showed that AML 1 was fused to a novel gene named MTG 16 ( Myeloid Translocation Gene on chromosome 16 ) which shows high homology to MTG 8 ( ETO / CDR ) and MTGR 1 . ^^^ |
|
| Interacting proteins: O75081 and Q06455 |
Pubmed |
SVM Score :0.0 |
| AML 1 ETO decreases ETO 2 ( MTG 16 ) interactions with nuclear receptor corepressor , an effect that impairs granulocyte differentiation . ^^^ |
|
| Interacting proteins: O75081 and Q06455 |
Pubmed |
SVM Score :0.0 |
| The Eight twenty one ( ETO ) homologues are nuclear repressor proteins including ETO , myeloid transforming gene related protein 1 ( MTGR 1 ) , and myeloid transforming gene chromosome 16 ( MTG 16 ) . ^^^ ETO and MTG 16 are both part of fusion proteins resulting from chromosomal translocations associated with acute myeloid leukemia . ^^^ Our results showed MTGR 1 and MTG 16 to be ubiquitously expressed in leukemic cell lines , whereas expression of ETO was observed only in an erythroleukemic cell line . ^^^ |
|
| Interacting proteins: O75081 and Q06455 |
Pubmed |
SVM Score :0.0 |
| While only three fusion partners of RUNX 1 namely ETO , ETV 6 and MTG 16 have been described so far , there is a plethora of ETV 6 fusion partners with about 20 partners described so far . ^^^ |
|
| Interacting proteins: O75081 and Q06455 |
Pubmed |
SVM Score :0.0 |
| Two members of the MTG / ETO family of transcriptional corepressors , MTG 8 and MTG 16 , are disrupted by chromosomal translocations in up to 15 % of acute myeloid leukemia cases . ^^^ |
|
| Interacting proteins: O75081 and Q06455 |
Pubmed |
SVM Score :0.0 |
| Acute myeloid leukemia 1 ( AML 1 ) gene on chromosome 21 is involved in several chromosomal translocations , including t ( 8 ; 21 ) and t ( 16 ; 21 ) , that produce chimeric fusion proteins AML 1 eight twenty one ( ETO ) and AML myeloid transforming gene chromosome 16 ( MTG 16 ) , which contribute to leukemogenesis . ^^^ Using fluorescence recovery after photobleaching ( FRAP ) , we demonstrated that a fusion of AML 1 with ETO or MTG 16 exhibits reduced intranuclear mobility compared with wild type AML 1 or either fusion partner . ^^^ |
|
| Interacting proteins: O75081 and Q06455 |
Pubmed |
SVM Score :0.0 |
| The Nervy homology 2 ( NHR 2 ) domain in ETO mediates oligomerization and AML1 / ETO ' s interactions with ETO , MTGR 1 , and MTG 16 , and with the corepressor molecules mSin3A and HDAC 1 and HDAC 3 . ^^^ Oligomerization is also required for AML1 / ETO ' s interactions with ETO , MTGR 1 , and MTG 16 , but not with other corepressor molecules . . ^^^ |
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