| Interacting proteins: O60907 and Q9BZK7 |
Pubmed |
SVM Score :0.0 |
| The expression of TBLR 1 overlaps but is distinct from that of TBL 1 . ^^^ |
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| Interacting proteins: O60907 and Q9BZK7 |
Pubmed |
SVM Score :0.0 |
| Purification and functional characterization of the human N CoR complex : the roles of HDAC 3 , TBL 1 and TBLR 1 . ^^^ Corepressors N CoR and SMRT participate in diverse repression pathways and exist in large protein complexes including HDAC 3 , TBL 1 and TBLR 1 . ^^^ By using specific small interference RNAs ( siRNAs ) , we demonstrate that HDAC 3 is essential , whereas TBL 1 and TBLR 1 are functionally redundant but essential for repression by unliganded thyroid hormone receptor . ^^^ |
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| Interacting proteins: O60907 and Q9BZK7 |
Pubmed |
SVM Score :0.0 |
| Here , we report that transcriptional activation mediated by liganded nuclear receptors unexpectedly requires the actions of two highly related F box / WD 40 containing factors , TBL 1 and TBLR 1 , initially identified as components of an N CoR corepressor complex . ^^^ The role of TBLR 1 and TBL 1 in cofactor exchange appears to also operate for c Jun and NFkappaB and is therefore likely to be prototypic of similar mechanisms for other signal dependent transcription factors . . ^^^ |
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| Interacting proteins: O60907 and Q9BZK7 |
Pubmed |
SVM Score :0.0 |
| The best studied among them are N CoR / SMRT complexes containing TBL 1 ( transducin beta like protein 1 ) or TBLR 1 ( TBL 1 related protein ) . ^^^ Despite extensive studies of these complexes , there has been no direct in vivo evidence for the interaction of TBL 1 or TBLR 1 with TR or the possible involvement of such complexes in gene repression by any nuclear receptors in any animals . ^^^ |
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| Interacting proteins: O60907 and Q9BZK7 |
Pubmed |
SVM Score :0.0 |
| Here we show that TBL 1 and TBLR 1 , two WD 40 repeat proteins in the corepressor SMRT / N CoR complexes , are functionally redundant and essential for transcriptional repression by unliganded thyroid hormone receptors ( TR ) but not essential for transcriptional activation by liganded TR . ^^^ TBL 1 and TBLR 1 bind preferentially to hypoacetylated histones H2B and H 4 in vitro and have a critical role in targeting the corepressor complexes to chromatin in vivo . ^^^ |
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| Interacting proteins: O60907 and Q9BZK7 |
Pubmed |
SVM Score :0.0 |
| Although the N terminal RD binds transducin beta like protein 1 ( TBL 1 ) , TBLR 1 , and mSin 3 , deletion of this region did not affect the ability of N CoR to mediate repression by TR . ^^^ |
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| Interacting proteins: O60907 and Q9BZK7 |
Pubmed |
SVM Score :0.0 |
| Since Sif2p appears to be the yeast homolog of human TBL 1 and TBLR 1 , which function in the N CoR / SMRT complexes , its structural and oligomeric properties are likely to be very similar . . ^^^ |
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| Interacting proteins: O60907 and Q9BZK7 |
Pubmed |
SVM Score :0.0 |
| Recently , it has been shown that TBLR 1 , another homologue whose gene resides on chromosome 3 , and TBL1X act as a corepressor / coactivator exchanger for several nuclear receptors and transcription factors . ^^^ |
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