| Interacting proteins: O60907 and P63208 |
Pubmed |
SVM Score :0.0 |
| A series of protein interactions were identified in which Siah is physically linked to Ebi by association with a novel Sgt 1 homolog SIP that binds Skp 1 , a central component of Skp 1 Cullin F box complexes . ^^^ |
|
| Interacting proteins: O60907 and P63208 |
Pubmed |
SVM Score :0.0 |
| Siah interacting protein ( SIP ) was identified as a novel adaptor that physically links the E 3 ubiquitin ligase activity of Siah 1 with Skp 1 and Ebi F Box protein in the degradation of beta catenin , a transcriptional activator of TCF / LEF genes . ^^^ |
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| Interacting proteins: O60907 and P63208 |
Pubmed |
SVM Score :0.0 |
| The E 3 complex comprises , in addition to Siah 1 , Siah interacting protein ( SIP ) , the adaptor protein Skp 1 , and the F box protein Ebi . ^^^ |
|
| Interacting proteins: O60907 and P63208 |
Pubmed |
SVM Score :0.0 |
| Previously , we discovered a novel pathway for p 53 induced beta catenin degradation through a ubiquitin E 3 ligase complex involving Siah 1 , SIP ( CacyBP ) , Skp 1 , and Ebi . ^^^ |
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