| Interacting proteins: O60907 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O60907 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60907 and P35222 |
Pubmed |
SVM Score :0.0 |
| These results indicate that the association with DLG , EB 1 , and microtubulin is less critical for the maintenance of homeostasis by APC than has been suggested previously , and that proper beta catenin regulation by APC appears to be required for normal embryonic development and tumor suppression . . ^^^ |
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| Interacting proteins: O60907 and P35222 |
Pubmed |
SVM Score :0.0 |
| We identify PSD ( postsynaptic density ) 93 , beta catenin , and microtubule end binding protein EB 1 as APC binding partners . ^^^ |
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| Interacting proteins: O60907 and P35222 |
Pubmed |
SVM Score :0.0 |
| Siah interacting protein ( SIP ) was identified as a novel adaptor that physically links the E 3 ubiquitin ligase activity of Siah 1 with Skp 1 and Ebi F Box protein in the degradation of beta catenin , a transcriptional activator of TCF / LEF genes . ^^^ |
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| Interacting proteins: O60907 and P35222 |
Pubmed |
SVM Score :0.0 |
| Overexpression of EB 1 in human esophageal squamous cell carcinoma ( ESCC ) may promote cellular growth by activating beta catenin / TCF pathway . ^^^ In addition , EB 1 overexpression induced nuclear accumulation of beta catenin and promoted the transcriptional activity of beta catenin / T cell factor ( TCF ) . ^^^ Also , we found that EB 1 affected the interaction between beta catenin and APC . ^^^ Furthermore , EB 1 overexpression was correlated with cytoplasmic / nuclear accumulation of beta catenin in primary human ESCC . ^^^ Taken together , these results support the novel hypothesis that EB 1 overexpression may play a role in the development of ESCC by affecting APC function and activating the beta catenin / TCF pathway . . ^^^ |
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| Interacting proteins: O60907 and P35222 |
Pubmed |
SVM Score :0.0 |
| Previously , we discovered a novel pathway for p 53 induced beta catenin degradation through a ubiquitin E 3 ligase complex involving Siah 1 , SIP ( CacyBP ) , Skp 1 , and Ebi . ^^^ |
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| Interacting proteins: O60907 and P35222 |
Pubmed |
SVM Score :0.0 |
| In addition , we report that transiently expressed APC yellow fluorescent protein co localized with beta catenin , KAP3A , EB 1 , and DLG 1 at membrane clusters , but only beta catenin stimulated APC anchorage at the membrane . ^^^ |
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