| Interacting proteins: O60869 and P05412 |
Pubmed |
SVM Score :0.0 |
| This additional region of flanking sequence contains two modular regions : one of multiple PEA 3 elements between 684 bp and 1955 bp and a second region between 1929 bp and 1980 bps containing a second AP 1 site at 1929 bp , a MBF 1 / MEP 1 metal binding site , and a PPAR peroxisome proliferator element at 1950 bp . ^^^ |
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| Interacting proteins: O60869 and P05412 |
Pubmed |
SVM Score :0.0 |
| MBF 1 overexpressed by transient transfection cooperated with the transcription factor c Jun in activation of transcription but not with GATA 4 . ^^^ MBF 1 and c Jun induced the activity of a transiently transfected atrial natriuretic peptide promoter , whereas neither MBF 1 nor c Jun could induce the promoter alone . ^^^ Moreover , MBF 1 bound to c Jun in vitro . ^^^ These data suggest that MBF 1 is a transcriptional coactivator of c Jun regulating hypertrophic gene expression . ^^^ Our results indicate that MBF 1 participates in hormone induced cardiomyocyte hypertrophy and activates hypertrophic gene expression as a coactivator of c Jun . . ^^^ |
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| Interacting proteins: O60869 and P05412 |
Pubmed |
SVM Score :0.0 |
| Coactivator MBF 1 preserves the redox dependent AP 1 activity during oxidative stress in Drosophila . ^^^ We show that the conserved coactivator MBF 1 is a positive modulator of AP 1 . ^^^ Via a direct interaction with the basic region of Drosophila Jun ( D Jun ) , MBF 1 prevents an oxidative modification ( S cystenyl cystenylation ) of the critical cysteine and stimulates AP 1 binding to DNA . ^^^ An AP 1 dependent epithelial closure becomes sensitive to H2O2 in flies lacking MBF 1 . ^^^ We conclude that by preserving the redox sensitive AP 1 activity , MBF 1 provides an advantage during oxidative stress . . ^^^ |
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| Interacting proteins: O60869 and P05412 |
Pubmed |
SVM Score :0.0 |
| Analysis of Jun derivatives that selectively interact with these coactivators reveals that MBF 1 is crucial for the response to oxidative stress , whereas Chameau is important for the response to chemical and osmotic stress . ^^^ |
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