| Interacting proteins: O60716 and P35568 |
Pubmed |
SVM Score :0.0 |
| Insulin induced tyrosine phosphorylation of insulin receptor substrates results in the redistribution of CrkII between p 130 ( cas ) and insulin receptor substrate 1 . ^^^ A decrease in the association between CrkII and p 130 ( cas ) in response to insulin stimulation was detected in CHO cells stably expressing insulin receptor or insulin receptor substrate 1 , and in L 6 rat myoblasts . ^^^ Along with the decrease in the association of CrkII with p 130 ( cas ) , the amount of tyrosine phosphorylated insulin receptor substrate 1 co precipitated with CrkII increased in all cell types studied . ^^^ Insulin regulates the association of CrkII with p 130 ( cas ) by tyrosine dephosphorylation of p 130 ( cas ) and co ordinated tyrosine phosphorylation of insulin receptor substrate 1 . ^^^ Tyrosine phosphorylated insulin receptor substrate 1 serves as a docking protein for multiple adaptor proteins and competes with p 130 ( cas ) for CrkII . . ^^^ |
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| Interacting proteins: O60716 and P35568 |
Pubmed |
SVM Score :0.0 |
| Gab 1 is a member of the docking / scaffolding protein family which includes IRS 1 , IRS 2 , c Cbl , p 130 ( cas ) , and p 62 ( dok ) . ^^^ |
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| Interacting proteins: O60716 and P35568 |
Pubmed |
SVM Score :0.0 |
| Both the c Src and c Fyn tyrosine kinases are tyrosine phosphorylated and activated by cellular hGH stimulation and form part of the multiprotein signaling complex as does tensin , paxillin , IRS 1 , the p 85 subunit of phosphatidylinositol 3 kinase , C3G , SHC , Grb 2 , and Sos 1 . c Cbl and Nck are also tyrosine phosphorylated by cellular stimulation with hGH and associate with the p 130 ( Cas ) CrkII complex . c Jun N terminal kinase / stress activated protein kinase ( JNK / SAPK ) is activated in response to hGH in accordance with the formation of the abovementioned signaling complex , and hGH stimulated JNK / SAPK activity is increased in CrkII overexpressing NIH3T3 cells compared with vector transfected NIH3T3 cells . ^^^ |
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| Interacting proteins: O60716 and P35568 |
Pubmed |
SVM Score :0.0 |
| While IGF 1 induced activation of IRS 1 , Shc , PI3K , and MAPK pathways was unaffected , IGF 1 inducible beta 1 integrin associated kinase activity and association of Crk with p 130 ( CAS ) were significantly inhibited by RACK 1 overexpression . ^^^ |
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| Interacting proteins: O60716 and P35568 |
Pubmed |
SVM Score :0.0 |
| The injection of peroxovanadate also enhanced the tyrosine phosphorylation of many of the proteins known to function downstream of these receptors , including SHC , signal transducer and activator of transcription ( Stat ) 1alpha , beta , Stat 3 , Stat 5 , phospholipase C gamma , insulin receptor substrate 1 , GTPase activating protein , beta catenin , gamma catenin , p120cas , SHP 1 , and SHP 2 . ^^^ |
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