| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :1.1035277 |
| Hence , like beta catenin and plakoglobin , CAS interacts directly with E cadherin in vivo ; however , unlike beta catenin and plakoglobin , CAS does not interact with APC or alpha catenin . . 1.1035277^^^ By using the yeast two hybrid system , we confirmed the direct interaction between CAS and E cadherin and determined that CAS Arm repeats 1 to 10 are necessary and sufficient for this interaction . 0.53067041^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.84520404 |
| More recently , CAS has been shown to associate with E cadherin and its cofactors ( catenins ) , molecules that are involved in cell adhesion . 0.84520404^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :1.1776305 |
| CAS binds with E cadherin but not with beta catenin in the immunoprecipitation assays . 1.1776305^^^ We report herein that CAS ( CAS / CSE 1 ) , the human cellular apoptosis susceptibility protein , interacts with E cadherin and stimulates polarization of HT 29 human colon epithelial cells . 1.1039971^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| Whereas in the normal cells beta catenin is found in association with E cadherin , p 120 Cas is not . ^^^ In the ras transformed cells , the situation is reversed ; tyrosine phosphorylated p 120 Cas , but not tyrosine phosphorylated beta catenin , now is detected in E cadherin complexes . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| Identification of murine p 120 isoforms and heterogeneous expression of p120cas isoforms in human tumor cell lines . p120cas ( CAS ) is a protein tyrosine kinase substrate that associates directly with the cytoplasmic tail of the cell cell adhesion molecule E cadherin . ^^^ CAS is thus part of a multimolecular complex that , along with other cadherin binding proteins ( catenins ) , mediates interactions between E cadherin and the actin cytoskeleton . ^^^ Down regulation of E cadherin expression and defects in catenin function have been implicated in tumor metastasis , but the role of CAS in these processes has not been addressed . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| Here we show that the ubiquitin dependent proteolysis system is involved in the regulation of beta catenin turnover . beta catenin , but not E cadherin , p 120 ( cas ) or alpha catenin , becomes stabilized when proteasome mediated proteolysis is inhibited and this leads to the accumulation of multi ubiquitinated forms of beta catenin . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| Treatment with EGF inhibited cellular aggregation but did not affect either the levels of E cadherin or catenin expression nor the association of catenins ( beta catenin , plakoglobin / gamma catenin , or p 120 ( cas ) ) with E cadherin . ^^^ However , EGF treatment of the MDA MB 468 cell line dissociated actin , alpha actinin , and vinculin from the E cadherin catenin complex , and this coincided with a robust phosphorylation of beta catenin , plakoglobin / gamma catenin , and p 120 ( cas ) on tyrosine residues . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| Here , we report that a rapid and transient tyrosine phosphorylation of Cas is induced by TGF beta 1 and that E cadherin mediated cell cell interaction and the Src kinase pathway are involved in this early TGF beta signaling . ^^^ Stable transfection of E cadherin to L 929 cells and L cells as well as E cadherin blocking assay revealed that E cadherin mediated cell cell interactions were essential for both Cas phosphorylation and Src kinase activation . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical detection of the following oncomarkers was performed : Ki 67 , p 53 , CD 34 , CAS , Topoisomerase 2 alfa , nm 23 protein , E cadherin . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| Using the bisulfite modification technique and methylation specific PCR , we examined the aberrant promoter hypermethylation patterns of 9 tumor suppressor genes ( APC , DAPK , CDH 1 , HLTF , hMLH 1 , p 16 , RASSF1A , THBS 1 and TIMP 3 ) in 62 CSCCs , 30 CAs and 21 EAs . ^^^ After Bonferroni correction adjustment ( statistically significant at p < 0 . 0055 ) , we found that the aberrant hypermethylations of CDH 1 and DAPK were more frequent in CSCCs than in CAs ( 80 . 6 % vs . 43 . 3 % , p = 0 . 001 ; 77 . 4 % vs . 46 . 7 % , p = 0 . 005 ) , whereas HLTF and TIMP 3 were more frequently methylated in CAs ( 3 . 2 % vs . 43 . 3 % , p < 0 . 001 ; 8 . 1 % vs . 53 . 3 % , p = 0 . 001 ) . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| Intestinal HT 29 cells with dysfunction of E cadherin show increased pp60src activity and tyrosine phosphorylation of p 120 catenin . 1 . ^^^ The phosphorylation status of catenins was also investigated ; in HT 29 or in HT 29 M 6 cells treated with PMA , dysfunction of E cadherin was accompanied by an increased phosphorylation of p 120 catenin and by an elevated association of this protein to E cadherin . ^^^ These results suggest a role for pp60src and the pp60src substrate p 120 catenin in the control of E cadherin function in HT 29 cells . . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| Recent data suggest that p 120 catenin plays a role in the regulation of functionality of E cadherin , a protein essential for the establishment and maintenance of cell cell contacts . ^^^ Analysis of E cadherin was performed in order to compare the distribution of this protein and p 120 catenin . ^^^ Although no complete correlation was found between the expression of both proteins ( p = 0 . 077 ) , our results showed that alterations in the level or distribution of p 120 catenin were accompanied by lack of E cadherin reactivity in the membrane , whereas absence of p 120 catenin in the cytoskeleton fraction was associated with important decreases in the amount of E cadherin in this same fraction . ^^^ These results show that alterations in p 120 catenin levels are a common event in colorectal tumors , and suggest that the distribution of this protein and E cadherin is coordinately regulated . . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| Recombinant pp 60 ( c src ) efficiently phosphorylated both catenins in vitro , with stoichiometries of 1 . 5 and 2 . 0 mol of phosphate / mol of protein for beta catenin and p 120 catenin , respectively . pp 60 ( c src ) phosphorylation had opposing effects on the affinities of beta catenin and p 120 for the cytosolic domain of E cadherin ; it decreased ( in the case of beta catenin ) or increased ( for p 120 ) catenin / E cadherin binding . ^^^ However , a role for p 120 catenin in the modulation of beta catenin / E cadherin binding was not observed , since addition of phosphorylated p 120 catenin did not modify the affinity of phosphorylated ( or unphosphorylated ) beta catenin for E cadherin . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| O glycosylated E cadherin still binds to beta and gamma catenin , but not to p 120 catenin . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| In this study , we have evaluated the expression of alpha catenin but also of the other catenins ( beta , gamma and p 120 catenin ) and E cadherin in invasive breast cancer and statistically analysed these expressions with known clinicopathological parameters , c erbB 2 oncoprotein expression and patient survival . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| A novel role for p 120 catenin in E cadherin function . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| As reported for Fer , Fyn kinase is constitutively bound to p 120 catenin ; expression of K ras induces the phosphorylation of p 120 catenin on tyrosine residues increasing its affinity for E cadherin and , consequently , promotes the association of Fyn with the adherens junction complex . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| A core function for p 120 catenin in cadherin turnover . p 120 catenin stabilizes epithelial cadherin ( E cadherin ) in SW 48 cells , but the mechanism has not been established . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| No differences were seen in E cadherin catenin complexes in TS and TR MDCK , but N cadherin catenin complexes in TS MDCK have more abundant p 120 catenin . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| Loss or downregulation of E cadherin releases proteins , such as b catenin and p 120 catenin , from a membrane bound state into the cytoplasm , which are known to regulate transcriptional activity . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| Our study examines in situ lobular neoplastic lesions without concurrent invasive carcinoma for E cadherin gene alterations and protein expression , beta catenin , alpha catenin and p 120 catenin protein expression , and LOH at the chromosome 16q locus , with the goal of determining the events occurring at the stage of lobular neoplasia . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| Adherens junctions in myelinating Schwann cells stabilize Schmidt Lanterman incisures via recruitment of p 120 catenin to E cadherin . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| Blocked acinar development , E cadherin reduction , and intraepithelial neoplasia upon ablation of p 120 catenin in the mouse salivary gland . p 120 catenin is thought to be a key regulator of E cadherin function and stability , but its role ( s ) in vivo is poorly understood . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| Using western blot analysis and indirect immunostaining of retinal cryosections from 6 week old mice from a C 129 background we have determined changes , if any , in the levels of expression and localisation of a series of tight and adherens junction associated proteins , including Zonula Occludens 1 ( ZO 1 ) , occludin , N Cadherin , p 120 Catenin , alpha Catenin , gamma Catenin , beta Catenin , and E Cadherin . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| Rac 1 activity , which was induced by E cadherin engagement specifically at intermediate seeding densities , was required for the cadherin stimulated proliferation , and the control of Rac 1 activation by E cadherin was mediated by p 120 catenin . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| Knockdown of AF6i3 in epithelial cells , which express only this isoform , resulted in impaired E cadherin dependent intercellular adhesion due to concomitantly reduced association of E cadherin with F actin and p 120 catenin . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| We show that both p 120 catenin and mesenchymal cadherins are required for the invasiveness of E cadherin deficient cells . p 120 binding promotes the up regulation of mesenchymal cadherins and the activation of Rac 1 , which are essential for cell migration and invasiveness . p 120 also promotes invasiveness by inhibiting RhoA activity , independently of cadherin association . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| The expression of p120ctn protein in breast cancer is independent of alpha and beta catenin and E cadherin . ^^^ We used immunofluorescence to examine E cadherin , alpha catenin , beta catenin , and p120ctn ( formerly p120CAS ) expression in 91 cases of invasive ductal carcinoma . ^^^ In contrast , the catenin related protein p120ctn shows an expression pattern that is significantly unrelated to the other catenins ( or E cadherin ) , including complete loss of expression in approximately 10 % of the cases . ^^^ We conclude 1 ) that expression of E cadherin and alpha and beta catenin are generally retained at the membrane although frequently reduced or altered , 2 ) that complete loss of p120ctn expression is seen in approximately 10 % of the cases , and 3 ) that there is a significant correlation in the expression of E cadherin and the catenins but no correlation between these molecules and p120ctn , suggesting an absence of coordinate regulation . . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| The p120ctn protein ( formerly p120CAS ) is an armadillo family member that associates directly with the cytoplasmic tail of E cadherin and participates in the junctional complex responsible for cell cell adhesion . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| Expression of E cadherin , alpha , beta and gamma catenin and p120ctn , and of the adenomatous polyposis coli protein ( APC ) , together with function of the cadherin catenin complex was examined in a panel of gastric carcinoma cell lines , using immunocytochemistry , Western blotting and a cell cell aggregation assay . ^^^ Protein interactions were examined by sequential immunoprecipitation and immunoblotting with antibodies to E cadherin , alpha , beta and gamma catenin , p120ctn and APC . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| Armadillo proteins such as beta catenin and p120ctn are complexed to the cytoplasmic tail of E cadherin , whereas the vinculin related alphaE catenin protein forms a link to the actin cytoskeleton . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| Prognostic value of E cadherin , beta catenin , P120ctn in patients with transitional cell bladder cancer . ^^^ MATERIALS AND METHODS : By means of immunohistochemistry , we have investigated the expression of E cadherin , beta catenin and p120ctn in 102 transitional cell bladder carcinomas ( TCCs ) and statistically analysed these expressions with known clinicopathological parameters and patient survival . ^^^ RESULTS : Abnormal expression of E cadherin , beta catenin and p120ctn was associated with high grade and high stage of TCCs ( p < 0 . 001 ) . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| Co downregulation of cell adhesion proteins alpha and beta catenins , p120CTN , E cadherin , and CD 44 in prostatic adenocarcinomas . ^^^ Archival sections from 112 PACs were immunostained by an automated method ( Ventana Medical Systems , Tucson , AZ ) using monoclonal antibodies to alpha and beta catenins , p120CTN , E cadherin , N cadherin , and CD44s proteins . ^^^ Decreased expression of alpha and beta catenins , p120CTN , E cadherin , and CD44s proteins ( range , 5 % to 49 % ) was noted in PACs , and downregulation of each of these proteins correlated with high tumor grade ( P = . 02 to . 0001 ) . ^^^ Although loss of E cadherin and p120CTN each correlated with stage ( E cadherin , P = . 02 ; p120CTN , P = . 02 ) and ploidy ( E cadherin , P = . 0001 ; p120CTN , P = . 004 ) , downregulation of CD44s correlated with ploidy ( P = . 002 ) , serum PSA ( P = . 005 ) , and postoperative disease recurrence ( P = . 02 ) . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| The effect is associated with elevation of tyrosine phosphorylation of E cadherin , alpha catenin , beta 4051 mu catenin and gamma catenin , but not p120ctn . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| A highly conserved region present in the juxtamembrane domain of the cadherins has been shown to be necessary for p120ctn binding in E cadherin . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| Finally , expression of the p120ctn isoforms , which caused the branching phenotype , was associated with cellular relocalization of E cadherin in HaCaT cells . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| In GH 3 transfectants overexpressing E cadherin , E 2 had no effect on adhesiveness or on E cadherin and p120ctn distribution , but increased levels of active ezrin . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| Here , we address the importance of cadherin catenin interactions in vivo , using mutant variants of Drosophila epithelial cadherin ( DE cadherin ) that are selectively defective in p120ctn ( DE cadherin AAA ) or beta catenin armadillo ( DE cadherin Delta beta ) interactions . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| Reduced expression of beta and gamma catenin and p120ctn was found in 76 . 1 % , 94 . 3 % , and 63 . 6 % of the cases , respectively , being more frequent in lesions with reduced E cadherin expression . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| Studies by immunoprecipitation revealed that Fer kinase associated with N cadherin , gamma catenin , p120ctn , c Src ( a putative PTK and the product of the transforming , sarcoma inducing gene of Rous sarcoma virus ) , Rab 8 ( a GTPase ) , actin , vimentin , but not E cadherin , afadin , nectin 3 , and integrin beta 1 , suggesting Fer kinase associates not only with the actin based cell cell AJ structures , such as the N cadherin / catenin complex ( but not the alpha6beta1 integrin / laminin and the afadin / nectin complex ) , but also with intermediate filament based cell cell desmosomes . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| Calpeptin treatment of MDCK cells induced redistribution of E cadherin and beta catenin from intercellular junctions and reduced the association of p120ctn with the E cadherin / catenin complex . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| Contextual binding of p120ctn to E cadherin at the basolateral plasma membrane in polarized epithelia . ^^^ The cytoplasmic tail of E cadherin supports multiple protein interactions , including binding of beta catenin at the C terminus and of p120ctn to the juxtamembrane domain . ^^^ In Madin Darby canine kidney cells at steady state and after treatment with cycloheximide or temperature blocks , E cadherin and beta catenin localized to the Golgi complex , but p120ctn was found only at the basolateral plasma membrane . ^^^ Removal of S 1 resulted in missorting of E cadherin mutants ( EcadDeltaS 1 ) to the apical membrane ; beta catenin was simultaneously missorted and appeared at the apical membrane . p120ctn was not mistargeted with EcadDeltaS 1 , but could be recruited to the E cadherin catenin complex only at the basolateral membrane . ^^^ These findings help define the temporal assembly and sorting of the E cadherin catenin complex and show that membrane recruitment of p120ctn in polarized cells is contextual and confined to the basolateral membrane . . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| Furthermore , the p120ctn / E cadherin association is upregulated . ^^^ These data reveal a cooperative interaction between p120ctn and E cadherin that corresponds to mature functional adherens junctions able to initiate tight cell cell adhesion required for epithelium architecture and further affirm the gatekeeper role of p120ctn . . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To investigate the effect of catenin p 120 ( p120ctn ) translocation on the malignant features of hepatocellular carcinoma and its interrelation with beta catenin in E cadherin mediated cell signaling . ^^^ METHODS : Expression and translocation of p120ctn , tyrosine phosphorylation , and its binding capacity to E cadherin were detected by DNA transfection , immunoblotting and immunoprecipitation . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| Furthermore , stabilization of surface adhesive E cadherin , by overexpressing p120ctn , also blocks internalization and nuclear translocation of FGFR 1 . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| Recruitment of E cadherin associated with alpha and beta catenins and p120ctn to the nectin based cell cell adhesion sites by the action of 12 O tetradecanoylphorbol 13 acetate in MDCK cells . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| Regulation of E cadherin endocytosis by nectin through afadin , Rap 1 , and p120ctn . ^^^ Studies on the mode of action of the nectin afadin system using cell free assay revealed that afadin associated with nectin bound Rap 1 activated by trans interacting nectin , interacted with p120ctn , and strengthened the binding of p120ctn to E cadherin , eventually reducing non trans interacting E cadherin endocytosis . ^^^ These results indicate that trans interacting nectin inhibits non trans interacting E cadherin endocytosis through afadin , Rap 1 , and p120ctn and thereby further accumulates non trans interacting E cadherin to the nectin based cell cell adhesion sites for the formation of AJs . . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| Furthermore , we demonstrate that the E cadherin endocytosis dependent activation of Rap 1 is associated with and controlled by an increased Src kinase activity , and is paralleled by the colocalization of Rap 1 and E cadherin at the perinuclear Rab 11 positive recycling endosome compartment , and the association of Rap 1 with a subset of E cadherin catenin complexes that does not contain p120ctn . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| Increased expression of delta catenin / neural plakophilin related armadillo protein is associated with the down regulation and redistribution of E cadherin and p120ctn in human prostate cancer . delta Catenin , or neural plakophilin related armadillo protein , is a unique armadillo domain containing protein in that it is neural specific and primarily expressed in the brain . ^^^ By analyzing the same tumor cell clusters using consecutive sections , we showed that an increased delta catenin immunoreactivity was accompanied by the down regulation and redistribution of E cadherin and p120ctn , major cell junction proteins whose inactivation is frequently associated with cancer progression . ^^^ Furthermore , overexpression of delta catenin in tumorigenic CWR R 1 cells that are derived from human prostate cancer xenograft resulted in reduced immunoreactivity for E cadherin and p120ctn at the cell cell junction . ^^^ This is the first study comparing overexpression of delta catenin with the E cadherin / catenin system in cancer and shows that delta catenin may be intimately involved in regulating E cadherin / p120ctn cell cell adhesion in prostate cancer progression . . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| Simultaneous expression of caveolin 1 and E cadherin favored membrane distribution of E cadherin and its associated catenin ( p120ctn ) , even when caveolin 1 was only focally associated with adherens junctions . ^^^ Treatment with the specific src kinase inhibitor PP 1 increased E cadherin expression in IGtM 87 and SKOV 3 cells and enhanced membrane localization of both E cadherin and p120ctn . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| Interestingly , a marked decrease in RhoA activation coincident with E cadherin loss occurs during the EMT and correlates with the formation of a p120ctn / RhoA complex . ^^^ We also confirmed that altered localization of p120ctn corresponded with loss or cytoplasmic localization of E cadherin . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| Further studies showed the induction of p21 / Cip1 , p27 / Kip1 , E cadherin and dephosphorylated p120ctn expression was involved in DPA induced anticancer effects . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| P120ctn overexpression enhances beta catenin E cadherin binding and down regulates expression of survivin and cyclin D 1 in BEL 7404 hepatoma cells . ^^^ AIM : To understand the role of P120ctn in E cadherin mediated cell cell adhesion and signaling as well as in hepatoma cell biological function . ^^^ METHODS : We stably overexpressed p120ctn isoform 3A in BEL 7404 human hepatoma cells and studied the effect of p120ctn on beta catenin and E cadherin binding as well as p120ctn and beta catenin subcellular localization using immunoprecipitation , Western blotting and confocal microscopy . ^^^ The p120ctn E cadherin binding increased after transfection of p120ctn isoform 3A . ^^^ CONCLUSION : Our results indicate that p120ctn plays an important role in regulating the formation of E cadherin and catenin complex , cell apoptosis , cell cycle and cancer cell biological function . . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| Identification of a new catenin : the tyrosine kinase substrate p120cas associates with E cadherin complexes . p120cas is a tyrosine kinase substrate implicated in ligand induced receptor signaling through the epidermal growth factor , platelet derived growth factor , and colony stimulating factor receptors and in cell transformation by Src . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| We have evaluated the expression of E cadherin associated cytoplasmic molecules ( alpha , beta , and gamma catenins and p120cas ) to clarify whether or not the pattern of their expression could provide additional prognostic information beyond that from E cadherin alone . ^^^ Proportional hazard regression analysis showed that beta catenin , E cadherin , and alpha catenin have strong predictive value , whereas plakoglobin and p120cas have a somewhat lower predictive value . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| The p120cas gene encodes a protein tyrosine kinase substrate that associates with the cell cell adhesion protein complex containing E cadherin and its cytoplasmic cofactors alpha catenin , beta catenin , and plakoglobin . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| Immunoprecipitation confirmed a physical association of E cadherin with intracellular catenins ( alpha , beta , gamma catenin / plakoglobin and p120CAs ) . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| E cadherin mediated intercellular adhesion is regulated by a family of cytoplasmic proteins that include alpha , beta and gamma catenin and p120cas . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| Expression patterns of the novel catenin p120cas in gastrointestinal cancers . p120cas is involved in signal transduction upon src or growth factor stimulation as well as in E cadherin mediated cell adhesion and may play an important role in carcinogenesis . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| To investigate the alterations in E cadherin associated with cytoplasmic molecules including alpha catenin , beta catenin , gamma catenin , p120CAS , and IQGAP 1 in various endometrial cancers with different degree of differentiation , we examined the localization and expression of E cadherin and cytoplasmic molecules in 30 cases of both well and poorly differentiated endometrioid adenocarcinomas , using immunofluorescence and immunoblotting techniques . ^^^ |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P12830 |
Pubmed |
SVM Score :0.0 |
| NA |
|