| Interacting proteins: O60716 and P00533 |
Pubmed |
SVM Score :0.0 |
| Association with expression of abl , ras , fes , src , erbB , and Cas NS 1 oncogenes but not with myc . ^^^ This antigen was expressed on many pre B and B cell lymphomas , but not on A MuLV transformed fibroblasts , T cell lymphomas , or myelomonocytic leukemias , gp 160 ( 6C3 ) was expressed by most early B lineage spontaneous tumors , and early B tumors induced by replication defective MuLV containing oncogenes the products of which are associated with the cytoplasmic aspect of the plasma membrane , i . e . , fes , abl , H ras , bas , src , erbB , and Cas NS 1 . ^^^ |
|
| Interacting proteins: O60716 and P00533 |
Pubmed |
SVM Score :0.0 |
| Fifteen samples were also analyzed for EGFr content utilizing a Cell Analysis Systems ( CAS 200 ) image cytometer . ^^^ |
|
| Interacting proteins: O60716 and P00533 |
Pubmed |
SVM Score :0.0 |
| The SH 2 domain of CRK binds to several tyrosine phosphorylated proteins , including the epidermal growth factor receptor , p 130 ( Cas ) , Shc , and paxillin . ^^^ |
|
| Interacting proteins: O60716 and P00533 |
Pubmed |
SVM Score :0.0 |
| Tyrosine phosphorylated epidermal growth factor receptor was not dephosphorylated by RPTPalpha under these conditions , suggesting that p 130 ( cas ) is a specific substrate of RPTPalpha in living cells . ^^^ |
|
| Interacting proteins: O60716 and P00533 |
Pubmed |
SVM Score :0.0 |
| Furthermore , NRG 1Beta stimulated the formation of a multiprotein complex between erbB 2 , FAK , p 130 ( CAS ) and paxillin within 30 min , and induced lamellipodia with longitudinal elongation of the myocytes within days . ^^^ |
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| Interacting proteins: O60716 and P00533 |
Pubmed |
SVM Score :0.0 |
| MCF 7 cells overexpressing Cas exhibited increased phosphorylation of two c Src substrates , Tyr 845 in the kinase domain of the epidermal growth factor receptor ( EGFR ) and signal transducer and activator of transcription ( STAT ) 5b . ^^^ Importantly , Cas dependent protection from the antiproliferative effects of tamoxifen was reversed by the expression of dominant inhibitory variants of these substrates ( Y845F EGFR and COOH terminally truncated STAT5b ) . ^^^ Based on these findings , we suggest that the Cas / c Src / EGFR / STAT5 signaling axis is a major regulator of tamoxifen resistant breast cancer cell growth and survival . . ^^^ Physical and functional interactions between Cas and c Src induce tamoxifen resistance of breast cancer cells through pathways involving epidermal growth factor receptor and signal transducer and activator of transcription 5b . ^^^ |
|
| Interacting proteins: O60716 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60716 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|