| Interacting proteins: O60683 and P50542 |
Pubmed |
SVM Score :0.0 |
| We also observed that peroxisome abundance was reduced fivefold in PBD cells that are defective in the PEX 1 , PEX 5 , PEX 12 , PEX 6 , PEX 10 , and PEX 2 genes . ^^^ |
|
| Interacting proteins: O60683 and P50542 |
Pubmed |
SVM Score :0.0 |
| PEX 12 interacts with PEX 5 and PEX 10 and acts downstream of receptor docking in peroxisomal matrix protein import . ^^^ Using two hybrid studies , blot overlay assays , and coimmunoprecipitation experiments , we observed that the zinc binding domain of PEX 12 binds both PEX 5 , the PTS 1 receptor , and PEX 10 , another integral peroxisomal membrane protein required for peroxisomal matrix protein import . ^^^ Furthermore , we identified a patient with a missense mutation in the PEX 12 zinc binding domain , S320F , and observed that this mutation reduces the binding of PEX 12 to PEX 5 and PEX 10 . ^^^ Overexpression of either PEX 5 or PEX 10 can suppress this PEX 12 mutation , providing genetic evidence that these interactions are biologically relevant . ^^^ However , we find that loss of PEX 12 or PEX 10 does not reduce the association of PEX 5 with peroxisomes , demonstrating that these peroxins are not required for receptor docking . ^^^ |
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| Interacting proteins: O60683 and P50542 |
Pubmed |
SVM Score :0.0 |
| These mutants were classified into three groups : group 1 contained 10 pex 10 mutants ( 4 ts mutants among them ) ; group 2 included 19 mutants that failed to complement other pex testers : 1 pex 1 ; 2 pex 4 ( 1 ts ) ; 6 pex 5 ( 5 ts ) ; 3 pex 8 ; 6 ( 3ts ) pex 19 ; group 3 contained 22 `` multiple ' ' mutants . ^^^ |
|
| Interacting proteins: O60683 and P50542 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60683 and P50542 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60683 and P50542 |
Pubmed |
SVM Score :0.0 |
| NA |
|