| Interacting proteins: O60683 and O00623 |
Pubmed |
SVM Score :0.0 |
| We also observed that peroxisome abundance was reduced fivefold in PBD cells that are defective in the PEX 1 , PEX 5 , PEX 12 , PEX 6 , PEX 10 , and PEX 2 genes . ^^^ |
|
| Interacting proteins: O60683 and O00623 |
Pubmed |
SVM Score :0.0 |
| PEX 12 interacts with PEX 5 and PEX 10 and acts downstream of receptor docking in peroxisomal matrix protein import . ^^^ Using two hybrid studies , blot overlay assays , and coimmunoprecipitation experiments , we observed that the zinc binding domain of PEX 12 binds both PEX 5 , the PTS 1 receptor , and PEX 10 , another integral peroxisomal membrane protein required for peroxisomal matrix protein import . ^^^ Furthermore , we identified a patient with a missense mutation in the PEX 12 zinc binding domain , S320F , and observed that this mutation reduces the binding of PEX 12 to PEX 5 and PEX 10 . ^^^ Overexpression of either PEX 5 or PEX 10 can suppress this PEX 12 mutation , providing genetic evidence that these interactions are biologically relevant . ^^^ However , we find that loss of PEX 12 or PEX 10 does not reduce the association of PEX 5 with peroxisomes , demonstrating that these peroxins are not required for receptor docking . ^^^ |
|
| Interacting proteins: O60683 and O00623 |
Pubmed |
SVM Score :0.0 |
| The three peroxin genes , PEX 12 , PEX 2 , and PEX 10 , encode peroxisomal integral membrane proteins with RING finger at the C terminal part and are responsible for human peroxisome biogenesis disorders . ^^^ |
|
| Interacting proteins: O60683 and O00623 |
Pubmed |
SVM Score :0.0 |
| PEX 1 and PEX 6 encode ABC protein , and PEX 10 and PEX 12 also encode integral membrane protein , with RING finger . ^^^ |
|
| Interacting proteins: O60683 and O00623 |
Pubmed |
SVM Score :0.0 |
| We used PCR amplification of genomic DNA and sequencing to screen 91 unclassified PBD ZSS patients for mutations in PEX 1 , PEX 26 , PEX 6 , PEX 12 , PEX 10 , and PEX 2 . ^^^ |
|
| Interacting proteins: O60683 and O00623 |
Pubmed |
SVM Score :0.0 |
| Identification and characterization of three peroxins PEX 6 , PEX 10 and PEX 12 involved in glycosome biogenesis in Trypanosoma brucei . ^^^ A preliminary analysis of these proteins , the peroxins PEX 6 , PEX 10 and PEX 12 , was performed . ^^^ |
|
| Interacting proteins: O60683 and O00623 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60683 and O00623 |
Pubmed |
SVM Score :0.0 |
| NA |
|