| We also found that vinexin alpha but not beta was phosphorylated at tyrosine residue when c Abl or 5 Abl was co expressed . ^^^ A mutational analysis identified tyrosine 127 on vinexin alpha as a major site of phosphorylation by c or 5 Abl . ^^^ Abl kinase interacts with and phosphorylates vinexin . ^^^ In this study , we found that vinexin alpha as well as beta interacts with c Abl mainly through the third SH 3 domain , and that vinexin and c Abl were colocalized at membrane ruffles in rat astrocytes . ^^^ These results suggest that vinexin alpha is a novel substrate for Abl . . ^^^ |