| Interacting proteins: Q96J84 and O60500 |
Pubmed |
SVM Score :0.87599121 |
| Both native and recombinant Neph 1 associate with each other as dimers and multimers and interact with nephrin via their extracellular segments . 0.87599121^^^ |
|
| Interacting proteins: Q96J84 and O60500 |
Pubmed |
SVM Score :0.60788361 |
| It is reported that podocin interacts with nephrin and CD2AP , and that NEPH 1 interacts with nephrin . 0.60788361^^^ |
|
| Interacting proteins: Q96J84 and O60500 |
Pubmed |
SVM Score :0.54299324 |
| NEPH 1 binds to nephrin , another component of the slit diaphragm , and loss of either partner causes heavy proteinuria . 0.54299324^^^ |
|
| Interacting proteins: Q96J84 and O60500 |
Pubmed |
SVM Score :0.0 |
| It has significant similarity with several known Igsf proteins , including Drosophila RST ( irregular chiasm C roughest ) protein and mammalian KIRREL ( kin of irregular chiasm C roughest ) , NEPH 1 , and NPHS 1 ( nephrin ) proteins . ^^^ |
|
| Interacting proteins: Q96J84 and O60500 |
Pubmed |
SVM Score :0.0 |
| Proteinuria and perinatal lethality in mice lacking NEPH 1 , a novel protein with homology to NEPHRIN . ^^^ Based on similarity to NEPHRIN and abundant expression in kidney , this protein was designated NEPH 1 and embryonic stem cells containing the retroviral insertion in the Neph 1 locus were used to generate mutant mice . ^^^ These findings suggest that NEPH 1 , like NEPHRIN , may play an important role in maintaining the structure of the filtration barrier that prevents proteins from freely entering the glomerular urinary space . . ^^^ |
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| Interacting proteins: Q96J84 and O60500 |
Pubmed |
SVM Score :0.0 |
| NEPH 1 , a member of the immunoglobulin superfamily , is structurally related to nephrin . ^^^ NEPH 1 triggers AP 1 activation similarly to nephrin but requires the presence of Tec family kinases for efficient transactivation . ^^^ We conclude that NEPH 1 defines a new family of podocin binding molecules that are potential candidates for hereditary nephrotic syndromes not linked to either NPHS 1 or NPHS2 . . ^^^ |
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| Interacting proteins: Q96J84 and O60500 |
Pubmed |
SVM Score :0.0 |
| Together with the recently cloned NEPH 1 , NLG 1 establishes a new nephrin like subgroup of genes belonging to the immunoglobulin superfamily of cell adhesion molecules . ^^^ |
|
| Interacting proteins: Q96J84 and O60500 |
Pubmed |
SVM Score :0.0 |
| Null mutations of genes expressed in podocytes like WT 1 , nephrin , and NEPH 1 result in an embryo and perinatal lethal phenotype and therefore do not allow the functional analysis of these genes in the adult kidney . ^^^ |
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| Interacting proteins: Q96J84 and O60500 |
Pubmed |
SVM Score :0.0 |
| Nephrin and Neph 1 co localize at the podocyte foot process intercellular junction and form cis hetero oligomers . ^^^ The existence of a new subfamily of Nephrin like molecules including Neph 1 was recently described . ^^^ Genetic deletion of Nephrin or Neph 1 resulted in similar phenotypes of podocyte foot process effacement and proteinuria . ^^^ The subcellular localization of Neph 1 and the possibility that Nephrin and Neph 1 interact was investigated . ^^^ Like Nephrin and Podocin , Neph 1 was enriched in Triton 10 100 detergent resistant membrane fractions . ^^^ |
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| Interacting proteins: Q96J84 and O60500 |
Pubmed |
SVM Score :0.0 |
| Homodimerization and heterodimerization of the glomerular podocyte proteins nephrin and NEPH 1 . ^^^ Nephrin and NEPH 1 , the gene products of NPHS 1 and NEPH 1 , are podocyte membrane proteins of the Ig superfamily . ^^^ Similar to the nephrin knockout , mice lacking NEPH 1 show severe proteinuria leading to perinatal death . ^^^ This NEPH 1 Ig fusion protein labeled the glomerular capillary wall of mouse kidneys in a staining pattern identical to NEPH 1 and nephrin , prompting speculation that that NEPH 1 might form homodimers and / or heterodimers with nephrin . ^^^ NEPH 1 also precipitated nephrin , a protein with eight Ig domains and a fibronectin like domain . ^^^ |
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| Interacting proteins: Q96J84 and O60500 |
Pubmed |
SVM Score :0.0 |
| The importance of several of them ( nephrin , podocin , CD2AP , and Neph 1 ) in the maintenance of the glomerular filtration barrier has been demonstrated by the occurrence of massive proteinuria when they are defective . ^^^ |
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| Interacting proteins: Q96J84 and O60500 |
Pubmed |
SVM Score :0.0 |
| Also , the genes encoding the four major slit diaphragm proteins , nephrin , podocin , Neph 1 and CD 2 associated protein were sequenced in 38 patients with MCNS of varying severity . ^^^ |
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| Interacting proteins: Q96J84 and O60500 |
Pubmed |
SVM Score :0.0 |
| Placental and fetal membrane Nephrin and Neph 1 gene expression : response to inflammation . ^^^ Nephrin and Neph 1 are cell membrane proteins that restrict glomerular protein filtration and which are differentially expressed with renal inflammation . ^^^ We sought to investigate whether nephrin and Neph 1 were expressed in placenta and fetal membranes , and whether inflammation modified the expression . ^^^ Placenta and fetal membranes were obtained and real time polymerase chain reaction ( PCR ) performed for determination of nephrin and Neph 1 levels . ^^^ RESULTS : Nephrin and Neph 1 were expressed in both placenta and fetal membranes . ^^^ |
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| Interacting proteins: Q96J84 and O60500 |
Pubmed |
SVM Score :0.0 |
| Nephrin , Neph 1 and podocin seem to form a multifunctional receptor complex at the slit diaphragm . ^^^ |
|
| Interacting proteins: Q96J84 and O60500 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96J84 and O60500 |
Pubmed |
SVM Score :0.0 |
| NA |
|