| Nephrin fractionated in detergent resistant glomerular membrane fractions with Fyn and Yes . ^^^ Glomeruli in which Fyn , Yes , or Fyn and Yes were genetically deleted in mice were characterized to explore the relationship between these kinases and Nephrin . ^^^ Yes deletion had no identifiable effect on podocyte morphology but dramatically increased Nephrin phosphorylating activity . ^^^ Similar to Fyn deletion , simultaneous deletion of Fyn and Yes reduced Nephrin phosphorylating activity . ^^^ Although Yes appears to effect the regulation of Nephrin phosphorylation , the mechanism by which this occurs requires investigation . . ^^^ |