| Interacting proteins: O60462 and P17948 |
Pubmed |
SVM Score :0.0 |
| Both primary and metastatic melanoma cells were found to express the mRNAs encoding for vascular endothelial growth factor and placenta growth factor receptors ( KDR , Flt 1 , neuropilin 1 , and neuropilin 2 ) , and exposure of melanoma cells to these cytokines resulted in a specific proliferative response , supporting the hypothesis of a role of these angiogenic factors in melanoma growth . ^^^ |
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| Interacting proteins: O60462 and P17948 |
Pubmed |
SVM Score :0.0 |
| Using PCR analysis , we also identified partial sequences of multiple VEGF isoforms ( VEGF 188 , 183 , 164 , and 120 ) as well as VEGFR 1 , VEGFR 2 , and neuropilin 2 ( NP 2 ) from the OFPAE cell cDNA library . ^^^ |
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| Interacting proteins: O60462 and P17948 |
Pubmed |
SVM Score :0.0 |
| Reverse transcriptase polymerase chain reaction ( RT PCR ) is utilized to measure the VEGF receptors flt 1 , KDR / flk 1 , flt 4 , neuropilin 1 ( NRP 1 ) , and neuropilin 2 ( NRP 2 ) . ^^^ |
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| Interacting proteins: O60462 and P17948 |
Pubmed |
SVM Score :0.0 |
| Stimulation by either 50 ng / ml VEGF A 165 or by 24 h of anoxia resulted in an altered pattern of receptor expression for VEGF R 2 ( Flk 1 ) , VEGF R 3 ( Flt 4 ) , neuropilin 1 , and neuropilin 2 , whereas VEGF R 1 ( Flt 1 ) remained unexpressed . ^^^ |
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| Interacting proteins: O60462 and P17948 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 ( Nrp 1 ) and Neuropilin 2 ( Nrp 2 ) are nonkinase vascular endothelial growth factor receptors ( VEGFR ) identified in several vertebrates , which function as coreceptors for the receptor tyrosine kinases VEGFR 1 and VEGFR 2 . ^^^ |
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| Interacting proteins: O60462 and P17948 |
Pubmed |
SVM Score :0.0 |
| MATERIALS AND METHODS : Using RT PCR we examined the expression of VEGF and its receptors , KDR , Flt 1 , NP 1 and NP 2 , in 8 human prostate cancer cell lines and then correlated the expression patterns with the ability of these cell lines to invade and migrate through membranes in a modified Boyden Chamber assay in the presence and absence of VEGF . ^^^ |
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| Interacting proteins: O60462 and P17948 |
Pubmed |
SVM Score :0.0 |
| Although much is known about the biology of vascular endothelial growth factor ( VEGF ) and its cognate receptors ( VEGFRs ) , VEGFR 1 and VEGFR 2 , little is known about the roles of the VEGFRs neuropilin ( NP ) 1 and NP 2 in the primate endometrium . ^^^ |
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| Interacting proteins: O60462 and P17948 |
Pubmed |
SVM Score :0.0 |
| Vascular endothelial growth factor mediated cell survival signalling occurs via the classical tyrosine kinase receptors Flt 1 , KDR / Flk 1 and the more novel neuropilin ( NP ) receptors , NP 1 and NP 2 . ^^^ |
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| Interacting proteins: O60462 and P17948 |
Pubmed |
SVM Score :0.0 |
| Here , we examined the expression of VEGF A and its receptors VEGFR 1 , VEGFR 2 , NP 1 , and NP 2 in conditionally immortalized mouse podocytes cultured in undifferentiated and differentiated conditions using RT PCR and Western analysis . ^^^ Differentiated podocytes expressed eightfold higher VEGFR 2 mRNA levels than undifferentiated podocytes , whereas VEGFR 1 , sVEGFR 1 , NP 1 , and NP 2 mRNA levels were similar . ^^^ VEGF ( 165 ) induced a twofold increase in VEGFR 2 mRNA and protein levels , whereas VEGFR 1 , sVEGFR 1 , NP 1 , and NP 2 mRNA levels remained unchanged . ^^^ |
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| Interacting proteins: O60462 and P17948 |
Pubmed |
SVM Score :0.0 |
| Retinal mRNA expression of VEGF splice variants ( VEGF 188 , VEGF 164 , VEGF 120 ) , VEGF receptors ( VEGFR 1 , VEGFR 2 , Npn 1 , Npn 2 ) , and pigment epithelium derived factor ( PEDF ) were also examined . ^^^ |
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| Interacting proteins: O60462 and P17948 |
Pubmed |
SVM Score :0.0 |
| The mRNA expression of VEGF ( 165 ) and its receptors Flt 1 , KDR , NRP 1 , and NRP 2 was evaluated by real time reverse transcription polymerase chain reaction . ^^^ |
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| Interacting proteins: O60462 and P17948 |
Pubmed |
SVM Score :0.0 |
| These receptors include VEGFR 1 , VEGFR 2 , VEGFR 3 , neuropilin 1 ( NRP 1 ) , and NRP 2 . ^^^ |
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| Interacting proteins: O60462 and P17948 |
Pubmed |
SVM Score :0.0 |
| The mRNA and protein levels of NRP 1 , NRP 2 , VEGFR 1 , VEGFR 2 , and VEGFR 3 were semiquantitatively determined by real time PCR and Western blot , respectively . ^^^ RESULTS : In PBS treated HUVECs , mRNA levels of NRPs and VEGFRs were NRP 1 ( 0 . 013 ) , NRP 2 ( 0 . 007 ) , VEGFR 2 ( 0 . 006 ) , VEGFR 1 ( 0 . 0024 ) , and VEGFR 3 ( 0 . 0009 ) . ^^^ However , both mRNA and protein levels of VEGFR 1 and NRP 2 were not affected by TNF alpha . ^^^ |
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| Interacting proteins: O60462 and P17948 |
Pubmed |
SVM Score :0.0 |
| The mRNA levels of 13 genes including CD 147 ( receptor for CypA ) , PDGF BB , endothelin 1 ( ET 1 ) , vascular endothelial growth factor receptor 1 ( VEGFR 1 ) , VEGFR 2 , VEGFR 3 , neuropilin 1 ( NRP 1 ) , NRP 2 , eNOS , iNOS , nNOS , ICAM 1 , and PECAM 1 were semiquantitatively determined by real time RT PCR as standardized with a house keeping gene beta actin . ^^^ HMVECs L had much higher expressions of PDGF BB , ET 1 , VEGFR 2 , VEGFR 1 , VEGFR 3 , and NRP 2 than HAoSMCs and HCAECs ( P < 0 . 017 , ANOVA ) . ^^^ |
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| Interacting proteins: O60462 and P17948 |
Pubmed |
SVM Score :0.0 |
| Although mRNA for VEGF 121 , VEGF 165 , VEGFR 1 and NRP 2 was widely expressed , mRNA expression for VEGF 189 , VEGFR 2 and NRP 1 was linked to a malignant phenotype such as local invasion . ^^^ |
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| Interacting proteins: O60462 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60462 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60462 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
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