| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| Semaphorins A and E act as antagonists of neuropilin 1 and agonists of neuropilin 2 receptors . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| Human neuropilin 1 and neuropilin 2 map to 10p12 and 2q34 , respectively . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| We report the identification of a related protein , neuropilin 2 , whose mRNA is expressed by developing neurons in a pattern largely , though not completely , nonoverlapping with that of neuropilin 1 . ^^^ Unlike neuropilin 1 , which binds with high affinity to the three structurally related semaphorins Sema 3 , Sema E , and Sema 4 , neuropilin 2 shows high affinity binding only to Sema E and Sema 4 , not Sema 3 . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| Sema K 1 does not bind to neuropilin 1 or neuropilin 2 , the two receptors implicated in mediating the repulsive action of several secreted semaphorins , and thus it likely acts through a novel receptor . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| In situ hybridization analysis revealed that the population of cortical neurons used in our experiments express neuropilin 1 and neuropilin 2 , which are essential components of receptors for the class 3 semaphorins . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| The extracellular complement binding ( CUB ) and coagulation factor domains of neuropilin 2 confer specificity to the Sema 4 repulsive response , and these domains of neuropilin 1 are necessary and sufficient for binding of the Sema 3 semaphorin ( sema ) domain . ^^^ Lastly , neuropilin 1 can homomultimerize and form heteromultimers with neuropilin 2 . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| Endothelial cells express in addition the neuropilin 1 and neuropilin 2 coreceptors , which bind selectively to the 165 amino acid form of VEGF ( VEGF 165 ) . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 and neuropilin 2 show specificity in binding to different class 3 semaphorins , including Sema 3 , Sema E , and Sema 4 , suggesting that the specificity of action of these semaphorins is dictated by the complement of neuropilins expressed by responsive neurons . ^^^ These results support the idea that in sympathetic axons , the Sema 3 signal is mediated predominantly by neuropilin 1 oligomers , the Sema 4 signal by neuropilin 2 oligomers , and the Sema E signal by neuropilin 1 and 2 , either as homo or heterooligomers . . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 and neuropilin 2 co expression is significantly correlated with increased vascularity and poor prognosis in nonsmall cell lung carcinoma . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 and neuropilin 2 bind differentially to different class 3 semaphorins and are thought to provide the ligand binding moieties in receptor complexes mediating repulsive responses to these semaphorins . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 ( np 1 ) and neuropilin 2 ( np 2 ) are receptors for axon guidance factors belonging to the class 3 semaphorins . np 1 also binds to the 165 amino acid heparin binding form of VEGF ( VEGF ( 165 ) ) but not to the shorter VEGF ( 121 ) form , which lacks a heparin binding ability . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| These receptors are encoded by the neuropilin 1 gene , and we have recently found that the related neuropilin 2 gene also encodes a VEGF 165 receptor . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| Genomic organization of human neuropilin 1 and neuropilin 2 genes : identification and distribution of splice variants and soluble isoforms . ^^^ Neuropilin 1 ( NRP 1 ) and neuropilin 2 ( NRP 2 ) are both receptors for semaphorins , which regulate neuronal guidance , and vascular endothelial growth factor ( VEGF ) , an angiogenic factor . ^^^ Neuropilin 1 ( NRP 1 ) and neuropilin 2 ( NRP 2 ) are both receptors for semaphorins , which regulate neuronal guidance , and vascular endothelial growth factor ( VEGF ) , an angiogenic factor . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| Both primary and metastatic melanoma cells were found to express the mRNAs encoding for vascular endothelial growth factor and placenta growth factor receptors ( KDR , Flt 1 , neuropilin 1 , and neuropilin 2 ) , and exposure of melanoma cells to these cytokines resulted in a specific proliferative response , supporting the hypothesis of a role of these angiogenic factors in melanoma growth . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| The expression of mRNAs for neuropilin 1 , neuropilin 2 and soluble neuropilin was studied in whole kidney , sieved glomeruli and cultured podocytes by reverse transcription PCR , and neuropilin 1 mRNA expression in isolated single glomeruli was analysed by nested reverse transcription PCR . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| Expressions of neuropilin 1 , neuropilin 2 and semaphorin 3A mRNA in the rat brain after middle cerebral artery occlusion . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| Differential expression of neuropilin 1 and neuropilin 2 in arteries and veins . ^^^ Neuropilin 1 ( np 1 ) and neuropilin 2 ( np 2 ) are receptors for class 3 semaphorins and for several isoforms of VEGF . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| We found that lung cancers ( n = 34 ) always express the neuropilin 1 receptor for secreted semaphorins , whereas 82 % expressed the neuropilin 2 receptor . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| The neuropilin 1 ( np 1 ) and neuropilin 2 ( np 2 ) receptors function as receptors for the axon guidance factors belonging to the class 3 semaphorin subfamily . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| Targeting of both mouse neuropilin 1 and neuropilin 2 genes severely impairs developmental yolk sac and embryonic angiogenesis . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| Blockade of NG 2 with antibody and blockade of neuropilin 2 but not neuropilin 1 both promoted axon growth from astrocytes to meningeal cells . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| We investigated the molecular guidance mechanisms of GE cell migration in the neocortex and found neuropilin 1 ( Npn 1 ) or neuropilin 2 ( Npn 2 ) on the GE cells . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| The neuropilin 1 ( NRP 1 ) and neuropilin 2 ( NRP 2 ) receptors can bind the class 3 semaphorin subfamily and the heparin binding forms of vascular endothelial growth factor ( VEGF ) and placenta growth factor ( PlGF ) . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| The primary structure of Neuropilin 1 and Neuropilin 2 is well conserved and is divided into four domains , CUB ( a1 / a2 ) domain , FV / FVIII ( b1 / b2 ) domain , MAM ( c ) domain , and ( d ) domain that contains a transmembrane and a short cytoplasmic region . ^^^ Both Neuropilin 1 and Neuropilin 2 have truncated and secreted form of splice variants . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| The interaction of Neuropilin 1 and Neuropilin 2 with tyrosine kinase receptors for VEGF . ^^^ The Neuropilin 1 ( NRP 1 ) and Neuropilin 2 ( NRP 2 ) receptors were initially described as receptors for axon guidance factors belonging to the class 3 Semaphorin sub family . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| Reverse transcriptase polymerase chain reaction ( RT PCR ) is utilized to measure the VEGF receptors flt 1 , KDR / flk 1 , flt 4 , neuropilin 1 ( NRP 1 ) , and neuropilin 2 ( NRP 2 ) . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| Stimulation by either 50 ng / ml VEGF A 165 or by 24 h of anoxia resulted in an altered pattern of receptor expression for VEGF R 2 ( Flk 1 ) , VEGF R 3 ( Flt 4 ) , neuropilin 1 , and neuropilin 2 , whereas VEGF R 1 ( Flt 1 ) remained unexpressed . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| Two receptors , neuropilin 1 ( NP 1 ) and neuropilin 2 ( NP 2 ) , bind class 3 semaphorins , axon guidance molecules including SEMA3F , the gene for which was isolated from a 3p21 . 3 deletion in lung cancer . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 ( NP 1 ) and neuropilin 2 ( NP 2 ) are receptors for semaphorins , which act as axonal chemorepellents , and for members of the vascular endothelial growth factor ( VEGF ) family of angiogenic growth factors . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| In addition , receptors for the secreted semaphorins , neuropilin 1 and neuropilin 2 , have been shown to function as coreceptors for a subset of vascular endothelial growth factor ( VEGF ) isoforms and related growth factors . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| The neuropilin 1 ( np 1 ) and neuropilin 2 ( np 2 ) receptors form complexes with type A plexins . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| Message for VEGF and the VEGF receptors KDR , flt 1 , flt 4 , neuropilin 1 ( NRP 1 ) , and neuropilin 2 ( NRP 2 ) are measured with RT PCR . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 ( Nrp 1 ) and Neuropilin 2 ( Nrp 2 ) are nonkinase vascular endothelial growth factor receptors ( VEGFR ) identified in several vertebrates , which function as coreceptors for the receptor tyrosine kinases VEGFR 1 and VEGFR 2 . ^^^ Neuropilin 1 ( Nrp 1 ) and Neuropilin 2 ( Nrp 2 ) are nonkinase vascular endothelial growth factor receptors ( VEGFR ) identified in several vertebrates , which function as coreceptors for the receptor tyrosine kinases VEGFR 1 and VEGFR 2 . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| The results showed that a large number of hematopoietic growth factor and receptor genes ( Epo / R , GM CSF / R , G CSF / R , LIF , IL 3 , TPO , Flt 3 , SCF ) were expressed in both groups , while many other growth factors ( VEGF , IGF 2 , PDGFA , PDGFB , TGFbeta 1 ) and receptors ( neuropilin 1 , neuropilin 2 , TGFbeta R 1 ) were expressed . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 ( NRP 1 ) and neuropilin 2 ( NRP 2 ) are transmembrane glycoproteins that have been characterized as receptors for both semaphorins for neuronal guidance and vascular endothelial growth factor ( VEGF ) for angiogenesis . ^^^ Neuropilin 1 ( NRP 1 ) and neuropilin 2 ( NRP 2 ) are transmembrane glycoproteins that have been characterized as receptors for both semaphorins for neuronal guidance and vascular endothelial growth factor ( VEGF ) for angiogenesis . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| Semaphorin 3F stimulates growth cone collapse following binding to the closest relative to neuropilin 1 in the genome , neuropilin 2 . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| The class 3 Semaphorins Sema3A and Sema3F are potent axonal repellents that cause repulsion by binding Neuropilin 1 and Neuropilin 2 , respectively . ^^^ Interestingly , we found a differential requirement for these two Plexins : signaling via Neuropilin 1 is mediated principally by Plexin A 4 , whereas signaling via Neuropilin 2 is mediated principally by Plexin A 3 . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| The neuropilin 1 ( np 1 ) and the neuropilin 2 ( np 2 ) receptors bind vascular endothelial growth factor ( VEGF ) and class 3 semaphorins . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| In the motile breast cancer cell line C 100 , which expresses both neuropilin 1 ( NRP 1 ) and neuropilin 2 ( NRP 2 ) receptors , SEMA3F had a repulsive effect , which was blocked by anti NRP 2 antibody . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| It has been proposed that four members of the plexin A subfamily ( plexin As ; plexin A 1 , A 2 , A 3 , and A 4 ) and two neuropilins ( neuropilin 1 and neuropilin 2 ) form complexes and serve as receptors for class 3 secreted semaphorins ( Semas ) , potent neural chemorepellents . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| We also found that Sema3G binds Neuropilin 2 , but not Neuropilin 1 , and induces the repulsion of sympathetic axons , but not dorsal root ganglion axons , indicating that Sema3G utilizes Neuropilin 2 as a receptor to repel specific types of axons . . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 and 2 ( NP 1 , NP 2 ) are natural ligands for semaphorins 3A and 3F , respectively . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| Following up on that initial observation , we have now used real time quantitative reverse transcription polymerase chain reaction to demonstrate induction of genes encoding neuropilin 1 ( NP 1 ) , which , like NP 2 , serves as a coreceptor for members of the class 3 semaphorin family of axonal guidance molecules and of five of the six known class 3 semaphorins ( Sema3A , Sema3B , Sema3C , Sema3E , and Sema3F , but not Sema3D ) in crushed or transected sciatic nerves . . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| VEGF acts through several receptors , including VEGF receptor 1 , VEGF receptor 2 , neuropilin 1 ( Npn 1 ) , and Npn 2 , but the exact role of these receptors in the development of retinal NV is unknown . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| The osteosarcomas with NRP 2 expression ( n=24 ) showed a significantly increased vascularity ( P < 0 . 0014 , Mann Whitney U test ) . ^^^ Osteosarcomas with NRP 2 showed significantly poorer prognosis than those without NRP 2 ( P=0 . 016 , Wilcoxon ' s test ) . ^^^ NRP 2 expression cooperatively promotes angiogenesis and growth in osteosarcomas with VEGF expression . . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| In the present study , we first show that VEGF selectively up regulates NRP 1 but not NRP 2 via the VEGF receptor 2 dependent pathway . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| The mRNA expression of VEGF ( 165 ) and its receptors Flt 1 , KDR , NRP 1 , and NRP 2 was evaluated by real time reverse transcription polymerase chain reaction . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 ( NRP 1 ) and NRP 2 are related transmembrane receptors that function as mediators of neuronal guidance and angiogenesis . ^^^ Neuropilin 1 ( NRP 1 ) and NRP 2 are related transmembrane receptors that function as mediators of neuronal guidance and angiogenesis . ^^^ During avian blood vessel development NRP 1 is expressed only in arteries whereas NRP 2 is expressed in veins . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| Although SEMA3F binds NRP 2 with 10 fold greater affinity than NRP 1 , the effects in MCF 7 were mediated by NRP 1 . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| In vascular endothelial cells , NRP 1 functions as an isoform specific receptor for VEGF 165 and has predominant expression compared to NRP 2 . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| We examined the gene expression of vascular endothelial growth factor ( VEGF ) A , Flt 1 , KDR , NRP 1 and NRP 2 in 37 gliomas by real time reverse transcriptase PCR ( real time RT PCR ) as well as immunohistochemical analysis . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| In summary , two nrp 1 and two nrp 2 genes , with expression patterns similar to higher vertebrates , have been isolated from zebrafish . . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| Based on synteny , zebrafish nrp1b and the previously cloned nrp1a are orthologous to human nrp 1 , and zebrafish nrp2a and 2b orthologous to human nrp 2 . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| We investigated global gene expression in aerobic ( roller ) , microaerophilic ( NRP 1 ) and anaerobic ( NRP 2 ) cultures . ^^^ A number of genes were significantly up regulated as compared to aerobic culture ; 178 in NRP 1 , 210 in NRP 2 , 88 in both . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| Here , we observed in vitro that new ( 99m ) Tc labeled derivative of anti VEGF heptapeptide , ATWLPPR , binds to NRP 1 but not to NRP 2 . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Both NRP 1 and NRP 2 were expressed in Panc 1 cells , HPDE cells , and HUVECs but were expressed minimally in MIA PaCa 2 cells . ^^^ Panc 1 expressed 30 times more NRP 1 mRNA than NRP 2 mRNA . ^^^ NRP 1 immunoreactivity levels were much higher than NRP 2 immunoreactivity levels in Panc 1 and human pancreatic adenocarcinoma tissue specimens , whereas VEGFRs were not detected in either of these two settings . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| These receptors include VEGFR 1 , VEGFR 2 , VEGFR 3 , neuropilin 1 ( NRP 1 ) , and NRP 2 . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| The mRNA and protein levels of NRP 1 , NRP 2 , VEGFR 1 , VEGFR 2 , and VEGFR 3 were semiquantitatively determined by real time PCR and Western blot , respectively . ^^^ RESULTS : In PBS treated HUVECs , mRNA levels of NRPs and VEGFRs were NRP 1 ( 0 . 013 ) , NRP 2 ( 0 . 007 ) , VEGFR 2 ( 0 . 006 ) , VEGFR 1 ( 0 . 0024 ) , and VEGFR 3 ( 0 . 0009 ) . ^^^ CONCLUSIONS : These data demonstrate that HUVECs express higher mRNA levels of NRP 1 and NRP 2 than those of VEGFRs , and TNF alpha treatment significantly decreases the expression of VEGFR 2 , VEGFR 3 , and NRP 1 , which may be responsible for TNF alpha induced reduction of EC proliferation in response to VEGF ( 165 ) . . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| The mRNA levels of 13 genes including CD 147 ( receptor for CypA ) , PDGF BB , endothelin 1 ( ET 1 ) , vascular endothelial growth factor receptor 1 ( VEGFR 1 ) , VEGFR 2 , VEGFR 3 , neuropilin 1 ( NRP 1 ) , NRP 2 , eNOS , iNOS , nNOS , ICAM 1 , and PECAM 1 were semiquantitatively determined by real time RT PCR as standardized with a house keeping gene beta actin . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| Although mRNA for VEGF 121 , VEGF 165 , VEGFR 1 and NRP 2 was widely expressed , mRNA expression for VEGF 189 , VEGFR 2 and NRP 1 was linked to a malignant phenotype such as local invasion . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| Although both antagonize VEGF binding / response to neuropilin ( NRP ) receptors , in lung cancer lines , SEMA3F is predominantly expressed and preferentially utilizes NRP 2 . ^^^ In H 460 cells , which express NRP 1 but not NRP 2 , SEMA3F did not prolong survival . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| Human coronary artery endothelial cells ( HCAECs ) treated with CRP showed a significant reduction of mRNA levels of VEGFR 2 , VEGFR 3 , NRP 1 , and NRP 2 by 34 % , 63 % , 41 % , and 43 % , respectively , as compared to untreated control cells ( p < 0 . 05 ) by real time PCR analysis . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| We examined the expression levels of NRP 1 and NRP 2 genes in 54 colon cancer cases and paired extraneoplastic tissue with quantitative real time polymerase chain reaction . ^^^ On the other hand , the gene expression levels of NRP 2 in the tumor ( 0 . 763+ / 0 . 791 ) were not decreased compared to those in the extraneoplastic tissue ( 0 . 508+ / 0 . 386 ) ( paired t test , p=0 . 0511 ) . ^^^ No significant relationship was noted between NRP 2 gene expression and prognosis . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| Both types of NRP , NRP 1 and NRP 2 , which only bind VEGF 164 , increased their expression about 2 folds only at P 30 , at levels similar to those observed for VEGF164 . . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| The neuropilin genes , NRP 1 and NRP 2 , share similar protein structure , but differ in their expression patterns , regulation , and ligand binding specificities . ^^^ NRPs vary in their expression patterns ; for example , endothelial cells express both NRP 1 and NRP 2 , lymphatic endothelial cells predominantly express NRP 2 , and epidermal cells predominantly express NRP 1 . ^^^ NRP expression can be differentially regulated by transcription factors , e . g . prox 1 induces NRP 2 while suppressing NRP 1 , or by growth factors , e . g . epidermal growth factor ( EGF ) induces NRP 1 but not NRP 2 . ^^^ Nearly all tumor cells express NRP 1 , NRP 2 , or both . ^^^ Carcinomas express NRP 1 , whereas neuronal tumors and melanomas predominantly express NRP 2 . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| Hormonal regulation and differential expression of neuropilin ( NRP ) 1 and NRP 2 genes in bovine granulosa cells . ^^^ Although much is known about the biology of vascular endothelial growth factor ( VEGF ) and its receptors , little is known about the role of the VEGF receptors neuropilin ( NRP ) 1 and NRP 2 in the process of bovine follicle development . ^^^ The aim of the present study was to examine the hormonal regulation of NRP 1 and NRP 2 mRNAs by real time PCR in follicles from the bovine ovary and in cultured granulosa cells . ^^^ In contrast , the NRP 2 gene was expressed only in the theca cells in the POF and the PRF . ^^^ These results are the first data showing that NRP 1 , but not NRP 2 , is expressed in the granulosa cells of bovine follicles and that NRP 1 gene expression is regulated by sex steroids . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| NRP 1 and NRP 2 were first identified for their key role in mediating axonal guidance in the developing nervous system through their interactions with class 3 semaphorins . ^^^ |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60462 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
|