| Interacting proteins: O60318 and P25205 |
Pubmed |
SVM Score :0.56990706 |
| Remarkably , GANP is associated with MCM 3 in B cells and MCM 3 is also up regulated in the GC area . 0.56990706^^^ |
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| Interacting proteins: O60318 and P25205 |
Pubmed |
SVM Score :0.0 |
| Structure , expression , and chromosomal localization of the human gene encoding a germinal center associated nuclear protein ( GANP ) that associates with MCM 3 involved in the initiation of DNA replication . ^^^ |
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| Interacting proteins: O60318 and P25205 |
Pubmed |
SVM Score :0.0 |
| Germinal center associated DNA primase ( GANP ) associated with MCM 3 of the DNA replication complex is up regulated selectively in germinal center B cells . ^^^ |
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| Interacting proteins: O60318 and P25205 |
Pubmed |
SVM Score :0.0 |
| MCM 3 binding GANP DNA primase is associated with a novel phosphatase component G5PR . ^^^ BACKGROUND : GANP , carrying DNA primase and MCM 3 binding domains , is up regulated in germinal centre B cells . ^^^ |
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| Interacting proteins: O60318 and P25205 |
Pubmed |
SVM Score :0.0 |
| In the present study , we have identified by two hybrid screens the germinal center associated protein ( GANP ) and MCM 3 associated protein ( MCM3AP ) , a splicing variant of GANP , as glucocorticoid receptor interacting proteins . ^^^ GANP and MCM3AP can bind to the MCM 3 protein involved in initiation of DNA replication . ^^^ |
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| Interacting proteins: O60318 and P25205 |
Pubmed |
SVM Score :0.0 |
| Moreover , we clarified a nuclear localization signal of human MCM 3 , and we find that mutagenesis on the nuclear localization signal of MCM 3 affected the binding of newly isolated MCM 3 assosiated protein , Map 80 . ^^^ The addition of recombinant Map 80 stimulated the amount of nuclear localized MCM 3 . ^^^ |
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| Interacting proteins: O60318 and P25205 |
Pubmed |
SVM Score :0.0 |
| MCM3AP , a novel acetyltransferase that acetylates replication protein MCM 3 . ^^^ We have isolated an MCM 3 associated protein ( MCM3AP ) in a two hybrid screen using MCM 3 . ^^^ Here we demonstrate that MCM3AP is an acetyltransferase which acetylates MCM 3 and that chromatin bound MCM 3 is acetylated in vivo . ^^^ The MCM 3 acetylase , MCM3AP , is also chromatin bound . ^^^ |
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| Interacting proteins: O60318 and P25205 |
Pubmed |
SVM Score :0.0 |
| The MCM 3 acetylase MCM3AP inhibits initiation , but not elongation , of DNA replication via interaction with MCM 3 . ^^^ MCM 3 acetylating protein , MCM3AP , binds and acetylates MCM 3 and inhibits cell cycle progression . ^^^ Both wild type and acetylase deficient mutant MCM3AP , however , can bind to chromatin through interaction with MCM 3 . ^^^ These results indicate that MCM 3 acetylase activity of MCM3AP is required to inhibit initiation of DNA replication and that association of MCM3AP to chromatin alone is not sufficient for the inhibition . ^^^ We also show that interaction between MCM 3 and MCM3AP is essential for nuclear localization and chromatin binding of MCM3AP . ^^^ |
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