| Interacting proteins: Q9ULK4 and O60244 |
Pubmed |
SVM Score :0.0 |
| Other Mediator subunits , DRIP 77 and DRIP 130 , were found either to bind STAT 2 without augmenting ISGF 3 transcriptional activity or to enhance ISGF 3 transcription without binding STAT 2 , but only DRIP 150 both enhanced IFN dependent transcription and coimmunoprecipitated with STAT 2 . ^^^ |
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| Interacting proteins: Q9ULK4 and O60244 |
Pubmed |
SVM Score :0.0 |
| We identified two cDNAs encoding new calcitonin receptor stimulating peptides ( CRSPs ) in porcine hypothalamus cDNA library by cross hybridization with the CRSP cDNA , and designated the second and third peptides as CRSP 2 and CRSP 3 . ^^^ The putative amino acid sequences of prepro CRSP 2 and prepro CRSP 3 showed higher identity with that of prepro CRSP 1 than that of prepro calcitonin gene related peptide ( CGRP ) , respectively , and these three CRSPs are considered to form a new family in the CGRP superfamily . ^^^ RT PCR analysis demonstrated that both CRSP 2 and CRSP 3 gene transcripts were expressed mainly in the central nervous system and thyroid gland . ^^^ Synthetic CRSP 2 and CRSP 3 stimulated cAMP production very weakly in LLC PK ( 1 ) cells compared with CRSP and calcitonin ( CT ) . ^^^ Furthermore , CRSP 2 and CRSP 3 did not elicit a cAMP elevation at all in the COS 7 cells expressing CT receptor or CT like receptor with or without one of receptor activity modifying proteins . ^^^ |
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| Interacting proteins: Q9ULK4 and O60244 |
Pubmed |
SVM Score :0.0 |
| We have recently identified in porcine brain a series of new peptides , designated calcitonin receptor stimulating peptide 1 ( CRSP 1 ) , CRSP 2 , and CRSP 3 , but failed to find their counterparts in humans and rodents by either database searching or experimental cross hybridization . ^^^ |
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| Interacting proteins: Q9ULK4 and O60244 |
Pubmed |
SVM Score :0.0 |
| In this review , we describe the structure and biological properties of calcitonin receptor stimulating peptide 1 ( CRSP 1 ) , CRSP 2 and CRSP 3 , the novel members of the CGRP family . ^^^ CRSP 2 has been identified in the pig and dog , and CRSP 3 has been identified only in the pig . ^^^ |
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