| Interacting proteins: O60244 and Q15648 |
Pubmed |
SVM Score :0.0 |
| In addition , we show that another member of the DRIP complex , DRIP 205 , interacts with the GR ligand binding domain in a hormone dependent manner and facilitates GR transactivation in concert with DRIP 150 . ^^^ These results suggest that DRIP 150 and DRIP 205 functionally link GR AF 1 and AF 2 , and represent important mediators of GR transcriptional enhancement . . ^^^ |
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| Interacting proteins: O60244 and Q15648 |
Pubmed |
SVM Score :0.0 |
| DRIP 150 and DRIP 205 have been implicated in coactivator actions but are unable to modulate GR activities . ^^^ |
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| Interacting proteins: O60244 and Q15648 |
Pubmed |
SVM Score :0.0 |
| Consistent with a TRAP Mediator coactivator role , transient overexpression of the TRAP 220 , TRAP 170 , and TRAP 100 subunits enhanced ligand dependent transcription by AR in cultured cells . ^^^ |
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| Interacting proteins: O60244 and Q15648 |
Pubmed |
SVM Score :0.0 |
| We have recently identified in porcine brain a series of new peptides , designated calcitonin receptor stimulating peptide 1 ( CRSP 1 ) , CRSP 2 , and CRSP 3 , but failed to find their counterparts in humans and rodents by either database searching or experimental cross hybridization . ^^^ In this study , we isolated cDNAs encoding precursors of bovine CRSP 1 , canine CRSP 1 , and canine CRSP 2 from their thyroid cDNA libraries . ^^^ |
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| Interacting proteins: O60244 and Q15648 |
Pubmed |
SVM Score :0.0 |
| In this review , we describe the structure and biological properties of calcitonin receptor stimulating peptide 1 ( CRSP 1 ) , CRSP 2 and CRSP 3 , the novel members of the CGRP family . ^^^ |
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| Interacting proteins: O60244 and Q15648 |
Pubmed |
SVM Score :0.0 |
| This complex contains homologs of a subset of yeast mediator / holoenzyme components ( including SRB 7 , SRB 10 , SRB 11 , MED 6 , and RGR 1 ) , homologs of other yeast transcriptional regulatory factors ( SOH 1 and NUT 2 ) , and , significantly , some components ( TRAP 220 , TRAP170 / hRGR1 , and TRAP 100 ) of a human thyroid hormone receptor associated coactivator complex . ^^^ |
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| Interacting proteins: O60244 and Q15648 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O60244 and Q15648 |
Pubmed |
SVM Score :0.0 |
| MED 14 and MED 1 differentially regulate target specific gene activation by the glucocorticoid receptor . ^^^ The Mediator subunits MED 14 and MED 1 have been implicated in transcriptional regulation by the glucocorticoid receptor ( GR ) by acting through its activation functions 1 and 2 . ^^^ To understand the contribution of these Mediator subunits to GR gene specific regulation , we reduced the levels of MED 14 and MED 1 using small interfering RNAs in U2OS hGR osteosarcoma cells and examined the mRNA induction by dexamethasone of four primary GR target genes , interferon regulatory factor 8 ( IRF 8 ) , ladinin 1 , IGF binding protein 1 ( IGFBP 1 ) , and glucocorticoid inducible leucine zipper ( GILZ ) . ^^^ We found that the GR target genes differed in their requirements for MED 1 and MED 14 . ^^^ GR dependent mRNA expression of ladinin 1 and IRF 8 required both MED 1 and MED 14 , whereas induction of IGFBP 1 mRNA by the receptor was dependent upon MED 14 , but not MED 1 . ^^^ |
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