| Interacting proteins: O60244 and O75586 |
Pubmed |
SVM Score :0.0 |
| A multiprotein complex isolated from murine cells is identified as a counterpart of the yeast Mediator of transcriptional regulation on the basis of the following : homologs of two subunits of yeast Mediator , Srb 7 and Med 7 , copurify with the complex ; peptide sequencing reveals , in addition , homologs of the yeast Mediator subunits Rgr 1 and Med 6 ; as with yeast Mediator , the mouse complex binds to the RNA polymerase 2 C terminal domain ( CTD ) and stimulates phosphorylation of the CTD by TFIIH . ^^^ |
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| Interacting proteins: O60244 and O75586 |
Pubmed |
SVM Score :0.0 |
| A complex that represses activated transcription and contains the human homologs of the yeast Srb 7 , Srb 10 , Srb 11 , Rgr 1 , and Med 6 proteins was isolated . ^^^ |
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| Interacting proteins: O60244 and O75586 |
Pubmed |
SVM Score :0.0 |
| These results suggest that distinct Mediator proteins in the Rgr 1 subcomplex are required for activator specific transcriptional activation and that the activation signals mediated by these Mediator proteins converge on Med 6 ( or the Srb 4 subcomplex ) to modulate Pol 2 activity . . ^^^ |
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| Interacting proteins: O60244 and O75586 |
Pubmed |
SVM Score :0.0 |
| This complex contains homologs of a subset of yeast mediator / holoenzyme components ( including SRB 7 , SRB 10 , SRB 11 , MED 6 , and RGR 1 ) , homologs of other yeast transcriptional regulatory factors ( SOH 1 and NUT 2 ) , and , significantly , some components ( TRAP 220 , TRAP170 / hRGR1 , and TRAP 100 ) of a human thyroid hormone receptor associated coactivator complex . ^^^ |
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