| Interacting proteins: O60239 and Q06187 |
Pubmed |
SVM Score :0.50050183 |
| Sab binds to and serves as a substrate for JNK in vitro , and was previously found to interact with the Src homology 3 ( SH 3 ) domain of Bruton ' s tyrosine kinase ( Btk ) . 0.50050183^^^ |
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| Interacting proteins: O60239 and Q06187 |
Pubmed |
SVM Score :0.0 |
| In this report , we describe the function of the Btk binding protein Sab ( SH 3 domain binding protein that preferentially associates with Btk ) , which we reported previously as a newly identified Src homology 3 domain binding protein . ^^^ |
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| Interacting proteins: O60239 and Q06187 |
Pubmed |
SVM Score :0.0 |
| Identification and characterization of a novel SH 3 domain binding protein , Sab , which preferentially associates with Bruton ' s tyrosine kinase ( BtK ) . ^^^ Protein interaction cloning method was used to identify a novel molecule , Sab , which binds to the SH 3 domain of Bruton ' s tyrosine kinase ( Btk ) , the deficient cytoplasmic tyrosine kinase in human 10 linked agammaglobulinemia and murine 10 linked immunodeficiency . ^^^ While Sab does not have a proline rich sequence , it was shown to bind to Btk through the commonly conserved structure among SH 3 domains . ^^^ Remarkably , Sab exhibited a high preference for binding to Btk rather than to other cytoplasmic tyrosine kinases , which suggests a unique role of Sab in the Btk signal transduction pathway . . ^^^ |
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