| Interacting proteins: O60239 and P45983 |
Pubmed |
SVM Score :1.0641674 |
| Sab binds to and serves as a substrate for JNK in vitro , and was previously found to interact with the Src homology 3 ( SH 3 ) domain of Bruton ' s tyrosine kinase ( Btk ) . 1.0641674^^^ Using deletion and site directed mutagenesis , we demonstrate that the most N terminal KIM in Sab is essential for JNK binding , and that , as with c Jun , physical interaction with JNK is necessary for Sab phosphorylation . 0.72904136^^^ |
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| Interacting proteins: O60239 and P45983 |
Pubmed |
SVM Score :0.0 |
| Activated SAPK 3 phosphorylates the mitochondrial protein Sab , an in vitro substrate of c Jun N terminal kinase ( JNK ) . ^^^ |
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| Interacting proteins: O60239 and P45983 |
Pubmed |
SVM Score :0.0 |
| Furthermore , peptides based on the KIMs from other proteins were significantly less potent JNK inhibitors than TI JIP , including a peptide from the JNK interactor Sab that contained all critical inhibitory residues present in TI JIP . ^^^ |
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| Interacting proteins: O60239 and P45983 |
Pubmed |
SVM Score :0.0 |
| Sab ( SH3BP5 ) , a novel mitochondria localized JNK interacting protein . ^^^ Protein protein interactions are critical for efficient signalling from JNK to multiple targets ; through a screen for interacting proteins , we identified a novel JNK interacting protein , Sab ( SH3BP5 ) . ^^^ Sab has previously been found to interact with the Src homology 3 domain of Bruton ' s tyrosine kinase ; however , the interaction with JNK occurs through a mitogen activated protein KIM ( kinase interaction motif ) in a region distinct from the Bruton ' s tyrosine kinase binding domain . ^^^ As with c Jun , the presence of this KIM is essential for Sab to act as a JNK substrate . ^^^ Interestingly , Sab is associated with the mitochondria and co localizes with a portion of active JNK after stress treatment . ^^^ |
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