Interacting proteins: Q8N3U4 and O60216 |
Pubmed |
SVM Score :0.0 |
Both complexes contain SMC 1 , SMC 3 , SCC 1 , and either one of the yeast Scc3p orthologs SA 1 and SA 2 . ^^^ |
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Interacting proteins: Q8N3U4 and O60216 |
Pubmed |
SVM Score :0.0 |
Human cohesion is composed of a stable heterodimer of the structural maintenance of chromosomes ( SMC ) family proteins , hSMC 1 and hSMC 3 , and non SMC components , hRAD 21 and SA 1 ( or SA 2 ) . ^^^ |
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Interacting proteins: Q8N3U4 and O60216 |
Pubmed |
SVM Score :0.0 |
Sister chromatid cohesion is maintained from DNA replication to metaphase to anaphase transition by multisubunit protein complexes called cohesin , which include at least four proteins , SMC1alpha , SMC 3 , Rad 21 and either SA 1 or SA 2 , in mammalian somatic cells . ^^^ |
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Interacting proteins: Q8N3U4 and O60216 |
Pubmed |
SVM Score :0.0 |
Polo like kinase 1 ( Plk 1 ) and Aurora B are required for this dissociation process , and Plk 1 can phosphorylate the cohesin subunits Scc 1 and SA 2 in vitro , consistent with the possibility that cohesin phosphorylation by Plk 1 triggers the dissociation of cohesin from chromosome arms . ^^^ We have identified numerous mitosis specific sites on Scc 1 and SA 2 , mutated them , and expressed nonphosphorylatable forms of both proteins stably at physiological levels in human cells . ^^^ |
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Interacting proteins: Q8N3U4 and O60216 |
Pubmed |
SVM Score :0.0 |
Interestingly , SRm 160 is also associated with factors involved in chromatin regulation and sister chromatid cohesion , specifically the cohesin subunits SMC1alpha , SMC 3 , RAD 21 , and SA 2 . ^^^ |
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Interacting proteins: Q8N3U4 and O60216 |
Pubmed |
SVM Score :0.0 |
STAG 2 and Rad 21 mammalian mitotic cohesins are implicated in meiosis . ^^^ We studied replacement of the mitotic by the meiotic cohesin complex during mouse germinal cell maturation , and we show that mammalian STAG 2 and Rad 21 are also involved in several meiosis stages . ^^^ Immunofluorescence results suggest that a cohesin complex containing Rad 21 and STAG 2 cooperates with a STAG 3 specific complex to maintain sister chromatid cohesion during the diplotene stage of meiosis . . ^^^ |
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Interacting proteins: Q8N3U4 and O60216 |
Pubmed |
SVM Score :0.0 |
The spherical entities attached to the LBCs centromeres in avian germinal vesicles , the so called protein bodies ( PBs ) , were enriched in SMC1alpha , SMC 3 , Rad 21 , STAG 1 and STAG 2 . ^^^ |
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