| Interacting proteins: O60216 and Q14683 |
Pubmed |
SVM Score :0.0 |
| The cohesin multiprotein complex containing SMC 1 , SMC 3 , Scc 3 ( SA ) , and Scc 1 ( Rad 21 ) is required for sister chromatid cohesion in eukaryotes . ^^^ |
|
| Interacting proteins: O60216 and Q14683 |
Pubmed |
SVM Score :0.0 |
| Sister chromatid cohesion is maintained from DNA replication to metaphase to anaphase transition by multisubunit protein complexes called cohesin , which include at least four proteins , SMC1alpha , SMC 3 , Rad 21 and either SA 1 or SA 2 , in mammalian somatic cells . ^^^ |
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| Interacting proteins: O60216 and Q14683 |
Pubmed |
SVM Score :0.0 |
| Interestingly , SRm 160 is also associated with factors involved in chromatin regulation and sister chromatid cohesion , specifically the cohesin subunits SMC1alpha , SMC 3 , RAD 21 , and SA 2 . ^^^ |
|
| Interacting proteins: O60216 and Q14683 |
Pubmed |
SVM Score :0.0 |
| We performed indirect immunostaining using antibodies against cohesins SMC1alpha , SMC1beta , SMC 3 , Rad 21 , and the SA / STAG family on chaffinch , pigeon and duck LBCs spreads , and frozen ovary sections . ^^^ The spherical entities attached to the LBCs centromeres in avian germinal vesicles , the so called protein bodies ( PBs ) , were enriched in SMC1alpha , SMC 3 , Rad 21 , STAG 1 and STAG 2 . ^^^ |
|
| Interacting proteins: O60216 and Q14683 |
Pubmed |
SVM Score :0.0 |
| Sister chromatid cohesion is mediated by cohesin , a ring shape complex made of four core subunits called Scc 1 , Scc 3 , Smc 1 , and Smc 3 in Saccharomyces cerevisiae ( Rad 21 , Psc 3 , Psm 1 , and Psm 3 in Schizosaccharomyces pombe ) . ^^^ |
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| Interacting proteins: O60216 and Q14683 |
Pubmed |
SVM Score :0.0 |
| Both complexes contain SMC 1 , SMC 3 , SCC 1 , and either one of the yeast Scc3p orthologs SA 1 and SA 2 . ^^^ |
|
| Interacting proteins: O60216 and Q14683 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Sister chromatid cohesion depends on a complex called cohesin , which contains at least four subunits : Smc 1 , Smc 3 , Scc 1 and Scc 3 . ^^^ |
|
| Interacting proteins: O60216 and Q14683 |
Pubmed |
SVM Score :0.0 |
| In budding yeast , the 14S cohesin complex comprises at least two classes of SMC ( structural maintenance of chromosomes ) proteins Smc 1 and Smc 3 and two SCC ( sister chromatid cohesion ) proteins Scc 1 and Scc 3 . ^^^ |
|
| Interacting proteins: O60216 and Q14683 |
Pubmed |
SVM Score :0.0 |
| In Saccharomyces cerevisiae , a complex consisting of Scc 1 , Smc 1 , Smc 3 , and Scc 3 proteins , called `` cohesin , ' ' mediates the connection between sister chromatids . ^^^ |
|
| Interacting proteins: O60216 and Q14683 |
Pubmed |
SVM Score :0.0 |
| In addition , Pol 2 interacts with SMC 1 , a subunit of the cohesin complex , and with ECO1 / CTF7 , required for establishing sister chromatid cohesion ; and pol 2 mutations act synergistically with smc 1 and scc 1 . ^^^ |
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| Interacting proteins: O60216 and Q14683 |
Pubmed |
SVM Score :0.0 |
| Cohesin contains four core subunits : Smc 1 , Smc 3 , Scc 1 , and Scc 3 . ^^^ The binding of ATP to Smc 1 , but not Smc 3 , was essential for Scc 1 ' s association with Smc1 / 3 heterodimers . ^^^ In contrast , mutations predicted to prevent hydrolysis of ATP bound to either head abolished cohesin ' s association with chromatin but not Scc 1 ' s ability to connect Smc 1 ' s head with that of Smc 3 . ^^^ |
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| Interacting proteins: O60216 and Q14683 |
Pubmed |
SVM Score :0.0 |
| One half of the SMC kleisin bridge is revealed here by a crystal structure of Smc 1 ' s ATPase complexed with Scc 1 ' s C terminal domain . ^^^ Interaction of Scc 1 ' s N terminus with Smc 3 depends on prior C terminus connection with Smc 1 . ^^^ There is little or no turnover of Smc 1 Scc1 interactions within cohesin complexes in vivo because expression of noncleavable Scc 1 after DNA replication does not hinder anaphase . . ^^^ |
|
| Interacting proteins: O60216 and Q14683 |
Pubmed |
SVM Score :0.0 |
| Cohesin ' s Smc 1 and Smc 3 `` heads ' ' are connected by an alpha kleisin subunit called Scc 1 , forming a tripartite ring with a diameter around 40 nm . ^^^ |
|
| Interacting proteins: O60216 and Q14683 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60216 and Q14683 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60216 and Q14683 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60216 and Q14683 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60216 and Q14683 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60216 and Q14683 |
Pubmed |
SVM Score :0.0 |
| NA |
|