| Interacting proteins: Q9NZC2 and O43914 |
Pubmed |
SVM Score :0.0 |
| Here we show that the triggering receptor expressed on myeloid cells 2 ( TREM 2 ) is a cell surface receptor on human monocyte derived DCs , which is associated with DAP 12 . ^^^ |
|
| Interacting proteins: Q9NZC2 and O43914 |
Pubmed |
SVM Score :0.0 |
| TREM 1 and TREM 2 activate myeloid cells by signalling through the adaptor protein DAP 12 . ^^^ |
|
| Interacting proteins: Q9NZC2 and O43914 |
Pubmed |
SVM Score :0.0 |
| We have earlier characterized the molecular genetic background of PLOSL by identifying mutations in two genes , DAP 12 and TREM 2 . ^^^ DAP 12 is a transmembrane adaptor protein that associates with the cell surface receptor TREM 2 . ^^^ To test a hypothesis that osteoclasts would be the cell type responsible for the bone pathogenesis in PLOSL , we analyzed the differentiation of peripheral blood mononuclear cells isolated from DAP 12 and TREM 2 deficient PLOSL patients into osteoclasts . ^^^ Here we show that loss of function mutations in DAP 12 and TREM 2 result in an inefficient and delayed differentiation of osteoclasts with a remarkably reduced bone resorption capability in vitro . ^^^ |
|
| Interacting proteins: Q9NZC2 and O43914 |
Pubmed |
SVM Score :0.0 |
| Furthermore , we show that plexin A 1 associates with the triggering receptor expressed on myeloid cells 2 ( Trem 2 ) , linking semaphorin signalling to the immuno receptor tyrosine based activation motif ( ITAM ) bearing adaptor protein , DAP 12 . ^^^ |
|
| Interacting proteins: Q9NZC2 and O43914 |
Pubmed |
SVM Score :0.0 |
| The triggering receptor expressed on myeloid cells 2 ( TREM 2 ) delivers intracellular signals through the adaptor DAP 12 to regulate myeloid cell function both within and outside the immune system . ^^^ |
|
| Interacting proteins: Q9NZC2 and O43914 |
Pubmed |
SVM Score :0.0 |
| These receptors associate with DAP 12 , and ligation of TREM 2 on the surface of macrophages leads to the release of nitric oxide . ^^^ Like TREM 1 and TREM 2 , TREM 3 signals through DAP 12 , and when TREM 3 is transfected into an NK cell line it mediates redirected lysis . ^^^ |
|
| Interacting proteins: Q9NZC2 and O43914 |
Pubmed |
SVM Score :0.0 |
| Here we complete the molecular pathology of PLOSL by identifying TREM 2 as the second PLOSL gene . ^^^ TREM 2 forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells . ^^^ |
|
| Interacting proteins: Q9NZC2 and O43914 |
Pubmed |
SVM Score :0.0 |
| This molecule , together with its partner receptor complex molecules including the killer cell activating receptors ( KARs ) , myeloid DAP 12 associating lectin 1 ( MDL 1 ) , triggering receptor expressed on myeloid cells 1 / 2 / 3 ( TREM 1 , TREM 2 , TREM 3 ) , and signal regulatory protein beta 1 ( SIRPbeta 1 ) , are expressed on the surface of NK and myeloid cells including antigen presenting cells . ^^^ |
|
| Interacting proteins: Q9NZC2 and O43914 |
Pubmed |
SVM Score :0.0 |
| RAW264 . 7 cells were transfected with FLAG tagged DAP 12 or TREM 2 and stimulated by anti FLAG antibody during in vitro osteoclastogenesis . ^^^ |
|
| Interacting proteins: Q9NZC2 and O43914 |
Pubmed |
SVM Score :0.0 |
| Recently , molecular analysis of affected families revealed mutations in the DAP 12 ( TYROBP ) or TREM 2 genes , providing an interesting example how mutations in two different subunits of a multi subunit receptor complex result in an identical human disease phenotype . ^^^ The association of PLOSL with mutations in the DAP 12 or TREM 2 genes has led to improved diagnosis of affected individuals . ^^^ |
|
| Interacting proteins: Q9NZC2 and O43914 |
Pubmed |
SVM Score :0.0 |
| The molecular defect has been identified in loss of function mutations in the TYROBP gene in Finnish and in Japanese patients , and in the TREM 2 gene in other families of different ethnic origins . ^^^ |
|
| Interacting proteins: Q9NZC2 and O43914 |
Pubmed |
SVM Score :0.0 |
| Dap 12 and Trem 2 , molecules involved in innate immunity and neurodegeneration , are co expressed in the CNS . ^^^ Our group has recently established the molecular background of PLOSL by identifying mutations in DAP 12 and TREM 2 genes . ^^^ To understand how loss of function of the immune cell activating DAP12 / TREM2 signaling complex leads to dementia and loss of myelin , we have analyzed here Dap 12 and Trem 2 expression in the mouse CNS . ^^^ We show that Dap 12 and Trem 2 are expressed from embryonic stage to adulthood , and demonstrate a highly similar expression pattern . ^^^ |
|
| Interacting proteins: Q9NZC2 and O43914 |
Pubmed |
SVM Score :0.0 |
| TREM 2 stimulation induced DAP 12 phosphorylation , extracellular signal regulated kinase phosphorylation , and cytoskeleton reorganization and increased phagocytosis . ^^^ |
|
| Interacting proteins: Q9NZC2 and O43914 |
Pubmed |
SVM Score :0.0 |
| The genetic causes of basal ganglia calcification , dementia , and bone cysts : DAP 12 and TREM 2 . ^^^ |
|
| Interacting proteins: Q9NZC2 and O43914 |
Pubmed |
SVM Score :0.0 |
| TREM 2 , a DAP 12 associated receptor , regulates osteoclast differentiation and function . ^^^ Deficiency of the signaling adapter protein DAP 12 or its associated receptor TREM 2 is associated with abnormal OC development in humans . ^^^ INTRODUCTION : TREM 2 ( triggering receptor expressed in myeloid cells 2 ) associates with the signaling adapter DAP 12 in osteoclasts ( OCs ) . ^^^ Genetic mutation or deletion of either the TYROBP ( DAP 12 ) or TREM 2 gene is associated with the human disorder of brain and bone , Nasu Hakola disease . ^^^ The expression of TREM 2 is unaltered in DAP 12 deficient OCs . ^^^ |
|
| Interacting proteins: Q9NZC2 and O43914 |
Pubmed |
SVM Score :0.0 |
| The genetic causes of basal ganglia calcification , dementia , and bone cysts : DAP 12 and TREM 2 . ^^^ It is caused by recessively inherited mutations in two genes encoding subunits of a cell membrane associated receptor complex : TREM 2 and DAP 12 . ^^^ METHODS : The authors compare neurologic and neuroradiologic follow up data of six patients carrying TREM 2 mutations with PLOSL due to defective DAP 12 genes . ^^^ RESULTS : Mutations in DAP 12 and TREM 2 result in a uniform disease phenotype . ^^^ In Finnish and Japanese patients with PLOSL , DAP 12 mutations predominate , whereas TREM 2 is mutated more frequently elsewhere . ^^^ |
|
| Interacting proteins: Q9NZC2 and O43914 |
Pubmed |
SVM Score :0.0 |
| A chimeric receptor composed of the extracellular domain of TREM 2 and the cytoplasmic domain of DAP 12 inhibited the TLR and FcR induced TNF production of DAP 12 deficient macrophages , whereas a TREM 1 chimera did not . ^^^ |
|
| Interacting proteins: Q9NZC2 and O43914 |
Pubmed |
SVM Score :0.0 |
| Together with its adaptor protein , the adaptor protein of 12 kDa also known as KARAP and TYROBP ( DAP 12 ) , triggering receptor expressed in myeloid cells 2 ( TREM 2 ) is a stimulatory membrane receptor of the immunoglobulin / lectin like superfamily , well known in myeloid cells . ^^^ |
|