| Interacting proteins: O43914 and Q9NP99 |
Pubmed |
SVM Score :0.0 |
| To mediate activation , TREM 1 associates with the transmembrane adapter molecule DAP 12 . ^^^ |
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| Interacting proteins: O43914 and Q9NP99 |
Pubmed |
SVM Score :0.0 |
| Like TREM 1 and TREM 2 , TREM 3 signals through DAP 12 , and when TREM 3 is transfected into an NK cell line it mediates redirected lysis . ^^^ |
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| Interacting proteins: O43914 and Q9NP99 |
Pubmed |
SVM Score :0.0 |
| TREM 1 , MDL 1 , and DAP 12 expression is associated with a mature stage of myeloid development . ^^^ The triggering receptor expressed on myeloid cells ( TREM 1 ) and the myeloid DAP 12 associating lectin ( MDL 1 ) are two recently identified receptors which associate non covalently with DAP 12 to form receptor complexes involved in monocytic activation and inflammatory response . ^^^ In this study , we investigated whether the expression of TREM 1 , MDL 1 , and DAP 12 correlated with myelomonocytic differentiation . ^^^ Northern and RT PCR revealed a strong expression of TREM 1 , MDL 1 , and DAP 12 in peripheral blood derived CD 14 ( + ) mature monocytes in contrast to undifferentiated bone marrow CD 34 ( + ) stem cells , and in the differentiated versus undifferentiated U 937 cells . ^^^ |
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| Interacting proteins: O43914 and Q9NP99 |
Pubmed |
SVM Score :0.0 |
| This molecule , together with its partner receptor complex molecules including the killer cell activating receptors ( KARs ) , myeloid DAP 12 associating lectin 1 ( MDL 1 ) , triggering receptor expressed on myeloid cells 1 / 2 / 3 ( TREM 1 , TREM 2 , TREM 3 ) , and signal regulatory protein beta 1 ( SIRPbeta 1 ) , are expressed on the surface of NK and myeloid cells including antigen presenting cells . ^^^ |
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| Interacting proteins: O43914 and Q9NP99 |
Pubmed |
SVM Score :0.0 |
| Modulation of hepatic granulomatous responses by transgene expression of DAP 12 or TREM 1 Ig molecules . ^^^ To investigate DAP 12 signaling during chronic inflammation , we constructed two adenoviral gene transfer vectors to express FLAG / DAP12 ( Ad FDAP 12 ) and the extracellular domain of mouse TREM 1 and the Fc portion of human IgG 1 ( Ad TREM 1 Ig ) , respectively , and observed their modulatory activities in a mouse model of hepatic granulomatous inflammation elicited by zymosan A . ^^^ In sharp contrast to the effect by Ad FDAP 12 , transgene expression in the liver of soluble form of extracellular domain of TREM 1 as an antagonist of DAP 12 signaling , remarkably inhibited zymosan A induced granuloma formation at all time points examined . ^^^ Our findings thus suggest that both DAP 12 and TREM 1 are involved in the development of granulomatous responses in the liver . . ^^^ |
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| Interacting proteins: O43914 and Q9NP99 |
Pubmed |
SVM Score :0.0 |
| TREM 1 and TREM 2 activate myeloid cells by signalling through the adaptor protein DAP 12 . ^^^ |
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| Interacting proteins: O43914 and Q9NP99 |
Pubmed |
SVM Score :0.0 |
| TREM 1 ( triggering receptor expressed on myeloid cells ) , a recently discovered receptor of the immunoglobulin superfamily , activates neutrophils and monocytes / macrophages by signaling through the adapter protein DAP 12 . ^^^ TREM 1 is the best characterized member of a growing family of DAP 12 associated receptors that regulate the function of myeloid cells in innate and adaptive responses . ^^^ |
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| Interacting proteins: O43914 and Q9NP99 |
Pubmed |
SVM Score :0.0 |
| Here , we report that MARV and EBOV activate TREM 1 on human neutrophils , resulting in DAP 12 phosphorylation , TREM 1 shedding , mobilization of intracellular calcium , secretion of proinflammatory cytokines , and phenotypic changes . ^^^ |
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| Interacting proteins: O43914 and Q9NP99 |
Pubmed |
SVM Score :0.0 |
| A chimeric receptor composed of the extracellular domain of TREM 2 and the cytoplasmic domain of DAP 12 inhibited the TLR and FcR induced TNF production of DAP 12 deficient macrophages , whereas a TREM 1 chimera did not . ^^^ |
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