| Interacting proteins: P43631 and O43914 |
Pubmed |
SVM Score :0.0 |
| Additionally , CD4+ T cell clones from patients but not those from controls acquired de novo expression of the DAP 12 molecule , an adapter chain that transmits CD158j derived signals . ^^^ Cumulative expression of CD158j and DAP 12 endowed cytolytic competence on CD4+CD28null T cells , allowing them to kill in the absence of T cell receptor triggering . ^^^ |
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| Interacting proteins: P43631 and O43914 |
Pubmed |
SVM Score :0.0 |
| A CD158b / j ( + ) gammadelta T cell clone derived in vitro from patient ' s peripheral blood lymphocytes was shown to express the activating form CD158j ( KIR2DS2 ) , which once cross linked stimulated the clone cytolytic function and costimulated the TCR induced production of cytokines , independently of the killer activating receptor associated protein ( KARAP ) . ^^^ |
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| Interacting proteins: P43631 and O43914 |
Pubmed |
SVM Score :0.0 |
| In clones that lacked expression of KARAP / DAP12 , the stimulatory KIR KIR2DS2 signaled through the JNK pathway , but did not activate the ERK pathway . ^^^ However , in the presence of KARAP / DAP12 , stimulation through KIR2DS2 led to phosphorylation of both JNK and ERK . ^^^ Transfection experiments confirmed that KIR2DS2 mediated ERK phosphorylation was dependent on KARAP / DAP12 . ^^^ In clones that lacked expression of KARAP / DAP12 , stimulation of KIR2DS2 did not induce cytotoxicity . ^^^ In clones that expressed KARAP / DAP12 , KIR2DS2 directly activated both cytotoxicity and IFN gamma production without the need for TCR derived signals . ^^^ |
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