| Interacting proteins: O43914 and P43403 |
Pubmed |
SVM Score :0.0 |
| Phosphorylated DAP 12 peptides bind ZAP 70 and Syk protein tyrosine kinases , suggesting that the activation pathway is similar to that of the T and B cell antigen receptors . . ^^^ |
|
| Interacting proteins: O43914 and P43403 |
Pubmed |
SVM Score :0.0 |
| Moreover , we demonstrate that although human DAP 12 reportedly binds the SH 2 domains of both Syk and Zap 70 , ligation of Ly49D leads to activation of Syk but not Zap 70 . ^^^ |
|
| Interacting proteins: O43914 and P43403 |
Pubmed |
SVM Score :0.0 |
| By contrast , triggering receptors assemble with homodimers of immune tyrosine based activation motif ( ITAM ) bearing adaptor molecules ( i . e . , DAP 12 , CD 3 11 ) that engage tyrosine kinases ( ZAP 70 and syk ) . . ^^^ |
|
| Interacting proteins: O43914 and P43403 |
Pubmed |
SVM Score :0.0 |
| DAP 12 , an ITAM bearing transmembrane adaptor protein , associates non covalently with receptors in natural killer ( NK ) and myeloid cells , and provides signaling function via the Syk and ZAP 70 tyrosine kinase activation pathways . ^^^ |
|
| Interacting proteins: O43914 and P43403 |
Pubmed |
SVM Score :0.0 |
| NA |
|