| Interacting proteins: O43913 and Q13416 |
Pubmed |
SVM Score :0.0 |
| Genetic interactions among orc 2 1 and orc 5 1 and other cell cycle genes provided further evidence for a role for the origin recognition complex ( ORC ) in DNA replication . ^^^ The silencing defect caused by orc 5 1 strengthened previous connections between ORC and silencing , and combined with the phenotypes caused by orc 2 mutations , suggested that the complex itself functions in both processes . . ^^^ |
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| Interacting proteins: O43913 and Q13416 |
Pubmed |
SVM Score :0.0 |
| This screen identified temperature sensitive alleles of ORC 2 and ORC 5 , as described elsewhere , and ABF 1 , NPL 3 , and YCL 54 , as described here . ^^^ Unlike the orc 2 , orc 5 , and abf 1 mutations that were isolated in the same ( or a similar ) screen for silencing mutants , neither temperature sensitive mutation in NPL 3 or YCL 54 caused overt replication defects . . ^^^ |
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| Interacting proteins: O43913 and Q13416 |
Pubmed |
SVM Score :0.0 |
| Restoration of silencing by sas 2 delta required ORC 2 and ORC 5 , but not SIR 1 or RAP 1 . ^^^ Furthermore , sas 2 delta suppressed the temperature sensitivity , but not the silencing defect of orc 2 1 and orc 5 1 . ^^^ |
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| Interacting proteins: O43913 and Q13416 |
Pubmed |
SVM Score :0.0 |
| Although all orc 2 and orc 5 mutations were recessive in the conventional sense , this dominant phenotype was shared with other orc 5 alleles and an orc 2 allele . ^^^ |
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| Interacting proteins: O43913 and Q13416 |
Pubmed |
SVM Score :0.0 |
| Orc 2 , Orc 3 , and Orc 5 also are detected in non proliferating cells like cardiac myocytes , adrenal cortical cells , and neurons , suggesting an additional role of these proteins in non proliferating cells . ^^^ |
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| Interacting proteins: O43913 and Q13416 |
Pubmed |
SVM Score :0.0 |
| To explore the role of ORC in chromosomal condensation , we have identified a mutant of subunit 5 of the Drosophila melanogaster origin recognition complex ( Orc 5 ) and have characterized the phenotypes of both the Orc 5 and the previously identified Orc 2 mutant , k 43 . ^^^ |
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| Interacting proteins: O43913 and Q13416 |
Pubmed |
SVM Score :0.0 |
| The replication proteins ORC 2 , CDC45L and ORC 5 , which in wild type follicle cell nuclei localize to sites of gene amplification , are distributed throughout the entire follicle cell nucleus in E2f2 mutants , consistent with their use at many genomic replication origins rather than only at sites of gene amplification . ^^^ |
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| Interacting proteins: O43913 and Q13416 |
Pubmed |
SVM Score :0.0 |
| Cdc 23 also interacts with four subunits of the Schizosaccharomyces pombe origin recognition complex ( ORC ) in yeast two hybrid assay : Orc 1 , Orc 2 , Orc 5 and Orc 6 . ^^^ |
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| Interacting proteins: O43913 and Q13416 |
Pubmed |
SVM Score :0.0 |
| The ectopic genomic replication of E2f2 mutant follicle cells can be suppressed by reducing the Orc 2 , Orc 5 , or Mcm 2 gene dose by half , indicating that small changes in pre RC gene expression can affect DNA synthesis in these cells . ^^^ |
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| Interacting proteins: O43913 and Q13416 |
Pubmed |
SVM Score :0.0 |
| The condensation defects observed resemble previously published reports for Orc 2 , Orc 5 , and Mcm 4 mutants . ^^^ |
|
| Interacting proteins: O43913 and Q13416 |
Pubmed |
SVM Score :0.0 |
| To study the function of the ORC during defined cell cycle periods , we performed cell cycle execution point analyses with strains containing a conditional mutation in the ORC 1 , ORC 2 or ORC 5 subunit of ORC . ^^^ |
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| Interacting proteins: O43913 and Q13416 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43913 and Q13416 |
Pubmed |
SVM Score :0.0 |
| NA |
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