| Interacting proteins: O43603 and P22466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43603 and P22466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43603 and P22466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43603 and P22466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43603 and P22466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43603 and P22466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43603 and P22466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43603 and P22466 |
Pubmed |
SVM Score :0.0 |
| Galanin ( GAL ) and GalR 2 receptor mRNAs were not detected in the neural lobe , under normal or osmotic stimulation conditions . ^^^ |
|
| Interacting proteins: O43603 and P22466 |
Pubmed |
SVM Score :0.0 |
| Bath application of [ Sar ( 1 ) , D Ala ( 12 ) ] gal ( 1 16 ) NH ( 2 ) ( AR M 961 ) , an agonist both at galanin R 1 and R 2 ( GALR 1 , GALR 2 ) receptors , evoked a reversible membrane hyperpolarization and inhibition of spike discharge in all LC neurons tested ( n=42 ) . ^^^ The selective GALR 2 agonist Gal ( 2 11 ) NH ( 2 ) ( AR M 1896 ) only caused inhibition of spike discharge and a slight hyperpolarization in 26 of 34 LC neurons tested , and was on a molar basis much weaker than AR M 961 . ^^^ |
|
| Interacting proteins: O43603 and P22466 |
Pubmed |
SVM Score :0.0 |
| Pharmacological analysis of tumor membrane homogenates with GAL and the specific GAL receptor GalR 2 agonist , AR M 1896 , revealed that the GAL receptor GalR 1 is most likely the receptor responsible for the observed GAL binding in the glioblastomas . ^^^ |
|
| Interacting proteins: O43603 and P22466 |
Pubmed |
SVM Score :0.0 |
| The neuropeptide galanin ( Gal ) and its receptors ( GalR 1 , GalR 2 , and GalR 3 ) are expressed in spinal cord . ^^^ Galanin ( 1 29 ) and Gal ( 1 30 ) are both high affinity agonists to GalR1 / R2 , whereas Gal ( 2 11 ) is a GalR 2 receptor agonist . ^^^ |
|
| Interacting proteins: O43603 and P22466 |
Pubmed |
SVM Score :0.0 |
| This effect is attributed to activation of peripheral GAL receptor 2 ( GalR 2 ) because a selective GalR 2 agonist ( AR M 1896 ) mimics the pro nociceptive actions of GAL . ^^^ Also , 44 . 5 % GalR 2 positive DRG neurons label for the capsaicin receptor ( vanilloid receptor 1 , VR 1 ) while 61 . 7 % of VR 1 positive DRG neurons label for GalR 2 ; 28 . 1 % of total DRG neurons are double labeled supporting the hypothesis that GAL induced effects are mediated by GalR 2 on capsaicin sensitive primary afferents . ^^^ Immunostaining for GAL peptide in digital nerves labels 46 . 4 % unmyelinated and 27 . 1 % myelinated axons , suggesting that afferents are a major source of ligand for peripheral GalR 2 . ^^^ These results suggest that peripheral GAL has an excitatory role in inflammatory pain , likely mediated by peripheral GalR 2 and that GAL can modulate VR 1 function . . ^^^ |
|
| Interacting proteins: O43603 and P22466 |
Pubmed |
SVM Score :0.0 |
| The functional interactions of the neuropeptide galanin ( GAL ) occur through its binding to three G protein coupled receptor subtypes : galanin receptor ( GALR ) 1 , GALR 2 and GALR 3 . ^^^ To evaluate the molecular alterations to GALR 2 and GALR 3 in the forebrain of GAL overexpressing mice , we performed complementary quantitative , real time PCR ( qPCR ) , in situ hybridization , and immunohistochemistry in select forebrain regions of GAL tg mice to characterize the neuronal distribution and magnitude of GAL mRNA and peptide expression and the consequences of genetically manipulating the neuropeptide GAL on the expression of GALR 2 and GALR 3 receptors . ^^^ Interestingly , regional qPCR analysis failed to reveal any changes in GALR 2 or GALR 3 expression in the GAL tg mice , suggesting that , contrary to GALR 1 , these receptor genes are not under ligand mediated regulatory control . ^^^ |
|
| Interacting proteins: O43603 and P22466 |
Pubmed |
SVM Score :0.0 |
| Results show that OECs express mRNAs for GAL and GAL receptor 2 ( GalR 2 ) but not for the two other GAL receptors , GalR 1 and GalR 3 . ^^^ |
|
| Interacting proteins: O43603 and P22466 |
Pubmed |
SVM Score :0.0 |
| Single cell gene expression analysis demonstrated that cholinergic NB neurons express mRNA for the GAL receptors GALR 1 , GALR 2 and GALR 3 , yet the levels of these mRNAs were unchanged across the three diagnostic groups . ^^^ |
|
| Interacting proteins: O43603 and P22466 |
Pubmed |
SVM Score :0.0 |
| GAL exerts diverse action via the GAL receptors ( GALR 1 , GALR 2 , and GALR 3 ) , which belong in the superfamily of G protein coupled transmembrane receptors . ^^^ GAL treatment of the keratinocytes resulted in an increase in cytosolic Ca2+ concentration , suggesting that GALR 2 is a functional receptor . ^^^ |
|
| Interacting proteins: P22466 and O43603 |
Pubmed |
SVM Score :0.0 |
| Galanin ( GAL ) and GalR 2 receptor mRNAs were not detected in the neural lobe , under normal or osmotic stimulation conditions . ^^^ |
|
| Interacting proteins: P22466 and O43603 |
Pubmed |
SVM Score :0.0 |
| Bath application of [ Sar ( 1 ) , D Ala ( 12 ) ] gal ( 1 16 ) NH ( 2 ) ( AR M 961 ) , an agonist both at galanin R 1 and R 2 ( GALR 1 , GALR 2 ) receptors , evoked a reversible membrane hyperpolarization and inhibition of spike discharge in all LC neurons tested ( n=42 ) . ^^^ The selective GALR 2 agonist Gal ( 2 11 ) NH ( 2 ) ( AR M 1896 ) only caused inhibition of spike discharge and a slight hyperpolarization in 26 of 34 LC neurons tested , and was on a molar basis much weaker than AR M 961 . ^^^ |
|
| Interacting proteins: P22466 and O43603 |
Pubmed |
SVM Score :0.0 |
| Pharmacological analysis of tumor membrane homogenates with GAL and the specific GAL receptor GalR 2 agonist , AR M 1896 , revealed that the GAL receptor GalR 1 is most likely the receptor responsible for the observed GAL binding in the glioblastomas . ^^^ |
|
| Interacting proteins: P22466 and O43603 |
Pubmed |
SVM Score :0.0 |
| The neuropeptide galanin ( Gal ) and its receptors ( GalR 1 , GalR 2 , and GalR 3 ) are expressed in spinal cord . ^^^ Galanin ( 1 29 ) and Gal ( 1 30 ) are both high affinity agonists to GalR1 / R2 , whereas Gal ( 2 11 ) is a GalR 2 receptor agonist . ^^^ |
|
| Interacting proteins: P22466 and O43603 |
Pubmed |
SVM Score :0.0 |
| This effect is attributed to activation of peripheral GAL receptor 2 ( GalR 2 ) because a selective GalR 2 agonist ( AR M 1896 ) mimics the pro nociceptive actions of GAL . ^^^ Also , 44 . 5 % GalR 2 positive DRG neurons label for the capsaicin receptor ( vanilloid receptor 1 , VR 1 ) while 61 . 7 % of VR 1 positive DRG neurons label for GalR 2 ; 28 . 1 % of total DRG neurons are double labeled supporting the hypothesis that GAL induced effects are mediated by GalR 2 on capsaicin sensitive primary afferents . ^^^ Immunostaining for GAL peptide in digital nerves labels 46 . 4 % unmyelinated and 27 . 1 % myelinated axons , suggesting that afferents are a major source of ligand for peripheral GalR 2 . ^^^ These results suggest that peripheral GAL has an excitatory role in inflammatory pain , likely mediated by peripheral GalR 2 and that GAL can modulate VR 1 function . . ^^^ |
|
| Interacting proteins: P22466 and O43603 |
Pubmed |
SVM Score :0.0 |
| The functional interactions of the neuropeptide galanin ( GAL ) occur through its binding to three G protein coupled receptor subtypes : galanin receptor ( GALR ) 1 , GALR 2 and GALR 3 . ^^^ To evaluate the molecular alterations to GALR 2 and GALR 3 in the forebrain of GAL overexpressing mice , we performed complementary quantitative , real time PCR ( qPCR ) , in situ hybridization , and immunohistochemistry in select forebrain regions of GAL tg mice to characterize the neuronal distribution and magnitude of GAL mRNA and peptide expression and the consequences of genetically manipulating the neuropeptide GAL on the expression of GALR 2 and GALR 3 receptors . ^^^ Interestingly , regional qPCR analysis failed to reveal any changes in GALR 2 or GALR 3 expression in the GAL tg mice , suggesting that , contrary to GALR 1 , these receptor genes are not under ligand mediated regulatory control . ^^^ |
|
| Interacting proteins: P22466 and O43603 |
Pubmed |
SVM Score :0.0 |
| Results show that OECs express mRNAs for GAL and GAL receptor 2 ( GalR 2 ) but not for the two other GAL receptors , GalR 1 and GalR 3 . ^^^ |
|
| Interacting proteins: P22466 and O43603 |
Pubmed |
SVM Score :0.0 |
| Single cell gene expression analysis demonstrated that cholinergic NB neurons express mRNA for the GAL receptors GALR 1 , GALR 2 and GALR 3 , yet the levels of these mRNAs were unchanged across the three diagnostic groups . ^^^ |
|
| Interacting proteins: P22466 and O43603 |
Pubmed |
SVM Score :0.0 |
| GAL exerts diverse action via the GAL receptors ( GALR 1 , GALR 2 , and GALR 3 ) , which belong in the superfamily of G protein coupled transmembrane receptors . ^^^ GAL treatment of the keratinocytes resulted in an increase in cytosolic Ca2+ concentration , suggesting that GALR 2 is a functional receptor . ^^^ |
|
| Interacting proteins: P22466 and O43603 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22466 and O43603 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22466 and O43603 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22466 and O43603 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22466 and O43603 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22466 and O43603 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22466 and O43603 |
Pubmed |
SVM Score :0.0 |
| NA |
|