| Interacting proteins: O43593 and P11473 |
Pubmed |
SVM Score :0.73439831 |
| Utilizing in vitro pull down methods , we find that Hr binds directly to VDR but insignificantly to nuclear receptors that are not functionally repressed by Hr . 0.73439831^^^ |
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| Interacting proteins: O43593 and P11473 |
Pubmed |
SVM Score :0.69849096 |
| Coimmunoprecipitation , DNA mobility shift assays , and chromatin immunoprecipitation revealed that Hr binds to VDR in human keratinocytes . 0.69849096^^^ |
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| Interacting proteins: O43593 and P11473 |
Pubmed |
SVM Score :0.0 |
| VDR mRNA expression was rapidly ( within 4 hr ) induced by physiological concentrations of 1 , 25 ( OH ) 2 D 3 in a dose dependent manner . ^^^ |
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| Interacting proteins: O43593 and P11473 |
Pubmed |
SVM Score :0.0 |
| The hydroxylapatite binding assay revealed average levels of 2 nmol of unoccupied 1 , 25 ( OH ) 2D3 receptor per mg of protein in insect cells at 72 hr after infection with recombinant baculovirus . ^^^ |
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| Interacting proteins: O43593 and P11473 |
Pubmed |
SVM Score :0.0 |
| The level of mRNA encoding the 1 , 25 dihydroxyvitamin D 3 receptor in the intestine of vitamin D deficient rats given 1 , 25 dihydroxyvitamin D 3 was determined by Northern blot analysis using a 32P labeled cDNA probe to the 1 , 25 dihydroxyvitamin D 3 receptor . mRNA levels increased 10 fold above deficiency levels at 6 and 12 hr after an intravenous dose of 1 , 25 dihydroxyvitamin D 3 , returning to predosing levels at 24 hr . ^^^ |
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| Interacting proteins: O43593 and P11473 |
Pubmed |
SVM Score :0.0 |
| RA and TRM both caused double the expected increase in BGP secretion at 16 hr after treatment with 1 , 25 dihydroxyvitamin D 3 . ^^^ |
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| Interacting proteins: O43593 and P11473 |
Pubmed |
SVM Score :0.0 |
| Bilateral lesions of the C 1 area decreased arterial pressure ( AP ) and heart rate ( HR ) to spinal cord transection levels and blocked the VDR induced by vagal stimulation and carotid sinus stretch . ^^^ Combined lesions of the contralateral NTS and C 1 area ipsilateral to the stimulated vagus nerve maintained AP and HR at normal levels , and totally blocked the VDR to vagal stimulation and carotid sinus stretch . ^^^ |
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| Interacting proteins: O43593 and P11473 |
Pubmed |
SVM Score :0.0 |
| We have used 1 , 25 dihydroxyvitamin D 3 ( 1 , 25 ( OH ) 2D3 ) to investigate autoregulation of homologous receptor and the control of c myc mRNA and protein expression in C3H / 10T1 / 2 cells . 2 . 10 nM 1 , 25 ( OH ) 2D3 stimulated 1 , 25 ( OH ) 2D3 receptor ( VDR ) synthesis in both non transformed C3H / 10T1 / 2 Cl 8 and in chemically transformed C3H / 10T1 / 2 Cl 16 cells within 4 hr of treatment . ^^^ The increase in VDR mRNA concentration in the chemically transformed C3H / 10T1 / 2 Cl 16 cells was maximal already at 4 hr , preceding the maximal increase in receptor concentration by 4 6 hr . 5 . ^^^ |
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| Interacting proteins: O43593 and P11473 |
Pubmed |
SVM Score :0.0 |
| The im injection of indomethacin 3 hr before expected ovulation delayed oviposition but increased neither shell thickness nor mRNA levels of CaBP D28K and of VDR . ^^^ |
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| Interacting proteins: O43593 and P11473 |
Pubmed |
SVM Score :0.0 |
| After 2 hr , less than 10 % of the initial VDR level could be measured . ^^^ In the presence of 1 , 25 ( OH ) 2vitamin D 3 , the VDR half life was 15 hr . ^^^ After 24 hr . less than 20 % of the initial VDR content was detectable , whereas , at this time point , when the cells were incubated with KH 1060 80 % of the VDR was still present . ^^^ |
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| Interacting proteins: O43593 and P11473 |
Pubmed |
SVM Score :0.0 |
| These findings suggest that VDR and HR , which are both zinc finger proteins , may be in the same genetic pathway that controls postnatal cycling of the hair follicle . . ^^^ |
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| Interacting proteins: O43593 and P11473 |
Pubmed |
SVM Score :0.0 |
| In the present study , we observed that 1alpha25 ( OH ) 2D3 was able to interfere at the transcriptional level with RA inhibition of TNF alpha induced c fos gene expression in cells when the cells were incubated with the vitamin for 24 hr before the RA treatment . 22 Oxa 1 , 25 ( OH ) 2D3 ( OCT ) , an analog derivative of 1alpha25 ( OH ) 2D3 , having high affinity for the vitamin D 3 receptor ( VDR ) , also interfered with the RA induced inhibition of c fos gene expression in the TNF alpha treated cells . ^^^ |
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| Interacting proteins: O43593 and P11473 |
Pubmed |
SVM Score :0.0 |
| Their phenotype similarities suggest the possibility of a functional relationship between HR and VDR . . ^^^ |
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| Interacting proteins: O43593 and P11473 |
Pubmed |
SVM Score :0.0 |
| However , Gemini analogs were up to 15 fold more potent than 1 , 25 ( OH ) ( 2 ) D ( 3 ) in recruiting the same cofactors to VDR in GST pull down assays using equal amounts of VDR from nuclear extracts of VDR transfected and hormone treated ( 24 hr ) COS 7 cells . ^^^ |
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| Interacting proteins: O43593 and P11473 |
Pubmed |
SVM Score :0.0 |
| We then explored the possibility that the abnormality in hair follicle cycling was associated with abnormal expression of hairless ( Hr ) , a putative transcriptional regulator known to regulate hair follicle cycling and recently shown to regulate VDR transcriptional activity . ^^^ Comparable to VDR , Hr was found in the basal cells of the epidermis and ORS of the hair follicle . ^^^ However , Hr was also found in the IRS and matrix of the follicle , regions with little or no VDR . ^^^ Levels of Hr were greater in the Vdr null mice compared to wildtype controls , results confirmed by quantitative RT PCR . ^^^ These changes are associated with increased expression of Hr , suggesting a role for VDR in regulating Hr expression . ^^^ |
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| Interacting proteins: O43593 and P11473 |
Pubmed |
SVM Score :0.0 |
| Parallel studies showed that VDR mRNA was significantly upregulated 12 24 hr after brief glutamate exposure in cultured neurons chronically treated with vitamin D 3 , but not in those with vehicle alone . ^^^ |
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| Interacting proteins: O43593 and P11473 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43593 and P11473 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43593 and P11473 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43593 and P11473 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43593 and P11473 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43593 and P11473 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43593 and P11473 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43593 and P11473 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43593 and P11473 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43593 and P11473 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43593 and P11473 |
Pubmed |
SVM Score :0.0 |
| NA |
|