| Interacting proteins: O43586 and Q05209 |
Pubmed |
SVM Score :0.0 |
| Mutations in CD2BP1 disrupt binding to PTP PEST and are responsible for PAPA syndrome , an autoinflammatory disorder . ^^^ |
|
| Interacting proteins: O43586 and Q05209 |
Pubmed |
SVM Score :0.0 |
| In conclusion , our data suggest PTP PEST plays a dual role in cell cytoskeleton organization , by promoting the turnover of focal adhesions required for cell migration , and by directly or indirectly regulating the proline , serine , threonine phosphatase interacting protein ( PSTPIP ) tyrosine phosphorylation level which may be involved in regulating cleavage furrow formation or disassembly during normal cell division . . ^^^ |
|
| Interacting proteins: O43586 and Q05209 |
Pubmed |
SVM Score :0.0 |
| PSTPIP is a substrate of PTP PEST and serves as a scaffold guiding PTP PEST toward a specific dephosphorylation of WASP . ^^^ We previously observed a defect in cytokinesis and an increase in the tyrosine phosphorylation of PSTPIP in PTP PEST deficient fibroblasts . ^^^ In this article , we demonstrate that PTP PEST and PSTPIP are found in the same complexes in vivo and that they interact directly through the CTH domain of PTP PEST and the coiled coil domain of PSTPIP . ^^^ We also demonstrate that PTP PEST dephosphorylates PSTPIP at tyrosine 344 . ^^^ Furthermore , we demonstrate that PSTPIP serves as a scaffold protein between PTP PEST and WASP and allows PTP PEST to dephosphorylate WASP . ^^^ |
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| Interacting proteins: O43586 and Q05209 |
Pubmed |
SVM Score :0.0 |
| Although Fyn enhanced WASp mediated Arp2 / 3 activation and was required for synapse formation , PTP PEST combined with PSTPIP 1 inhibited WASp driven actin polymerization and synapse formation . ^^^ |
|
| Interacting proteins: O43586 and Q05209 |
Pubmed |
SVM Score :0.0 |
| In addition , we demonstrate recruitment of the tyrosine phosphatase PTP PEST by PSTPIP into FasL . ^^^ |
|
| Interacting proteins: O43586 and Q05209 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43586 and Q05209 |
Pubmed |
SVM Score :0.0 |
| NA |
|