Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: Q9Y6Q6 and O43318	Pubmed	SVM Score :0.0
Receptor activator of NF kappaB ligand ( RANKL ) activates TAK 1 mitogen activated protein kinase kinase kinase through a signaling complex containing RANK , TAB 2 , and TRAF 6 . ^^^ Here , we demonstrate that TAK 1 and TAB 2 participate in the RANK signaling pathway . ^^^ Dominant negative forms of TAK 1 and TAB 2 inhibit NF kappaB activation induced by overexpression of RANK . ^^^ In 293 cells stably transfected with full length RANK , RANKL stimulation facilitates the formation of a complex containing RANK , TRAF 6 , TAB 2 , and TAK 1 , leading to the activation of TAK 1 . ^^^ These results suggest that the formation of the TRAF 6 TAB2 TAK 1 complex is involved in the RANK signaling pathway and may regulate the development and function of osteoclasts . . ^^^
Interacting proteins: Q9Y6Q6 and O43318	Pubmed	SVM Score :0.0
We investigated whether or not TAK 1 plays a role in RANK signaling . ^^^ A dominant negative form of TAK 1 was discovered to abolish the RANK induced activation of AP 1 and JNK . ^^^ The inhibitory effect of the TAK 1 mutant on RANK and TRAF induced NF kappaB activation was also observed , but less efficiently . ^^^ Our findings indicate that TAK 1 is involved in the MAPK cascade and NF kappaB pathway that is activated by RANK . . ^^^
Interacting proteins: Q9Y6Q6 and O43318	Pubmed	SVM Score :0.0
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