| Interacting proteins: O43318 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O43318 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O43318 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43318 and Q9Y4K3 |
Pubmed |
SVM Score :0.51149688 |
| Here we show that the MAPKK kinase TAK 1 acts upstream of NIK in the IL 1 activated signalling pathway and that TAK 1 associates with TRAF 6 during IL 1 signalling . 0.51149688^^^ |
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| Interacting proteins: O43318 and Q9Y4K3 |
Pubmed |
SVM Score :0.78807712 |
| Here we demonstrate that TAK 1 mitogen activated protein kinase kinase kinase and TAK 1 binding protein 2 ( TAB 2 ) , together with TRAF 6 , are recruited to LMP 1 through its N terminal transmembrane region . 0.78807712^^^ |
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| Interacting proteins: O43318 and Q9Y4K3 |
Pubmed |
SVM Score :1.0530522 |
| By coimmunoprecipitation , it was shown that SOCS 3 inhibited the association between TRAF 6 and TAK 1 and that SOCS 3 coimmunoprecipitated with TAK 1 and TRAF 6 . 1.0530522^^^ |
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| Interacting proteins: O43318 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| We find that the TAK 1 kinase complex phosphorylates and activates IKK in a manner that depends on TRAF 6 and Ubc 13 Uev1A . ^^^ |
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| Interacting proteins: O43318 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| Receptor proximal proteins involved include the adapter MyD 88 , IRAK , IRAK 2 , Tollip , TRAF 6 and TAK 1 . ^^^ |
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| Interacting proteins: O43318 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| New genes candidates for ectodermal dysplasia : TAB 2 , TRAF 6 and TAK 1 ] . ^^^ |
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| Interacting proteins: O43318 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| Recently , the association of the MAPK kinase kinase , transforming growth factor beta activated kinase 1 ( TAK 1 ) , with TRAF 6 was shown to mediate the IL 1 signaling to NF kappaB and JNK . ^^^ |
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| Interacting proteins: O43318 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| Here we demonstrate for the first time that human Pellino 2 interacts with TRAF 6 ( tumor necrosis factor receptor associated factor 6 ) and that both Pellino 1 and Pellino 2 also interact with TAK 1 ( transforming growth factor beta activated kinase 1 ) . ^^^ |
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| Interacting proteins: O43318 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| Ras associates with TLR 2 and activates the mitogen activated protein kinase ( MAPK ) extracellular signal regulated kinase ( ERK ) , whereas tumor necrosis factor receptor associated factor 6 ( TRAF 6 ) / transforming growth factor beta activated kinase 1 ( TAK 1 ) dependent signaling activates p 38 MAPK . ^^^ |
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| Interacting proteins: O43318 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| TAB 2 , a novel adaptor protein , mediates activation of TAK 1 MAPKKK by linking TAK 1 to TRAF 6 in the IL 1 signal transduction pathway . ^^^ Here we report the identification of TAB 2 , a novel intermediate in the IL 1 pathway that functionally links TAK 1 to TRAF 6 . ^^^ IL 1 stimulates translocation of TAB 2 from the membrane to the cytosol where it mediates the IL 1 dependent association of TAK 1 with TRAF 6 . ^^^ These results define TAB 2 as an adaptor linking TAK 1 and TRAF 6 and as a mediator of TAK 1 activation in the IL 1 signaling pathway . . ^^^ |
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| Interacting proteins: O43318 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| Here we report that ASK 1 binds to TAK 1 and dissociates TAK 1 from TNF receptor associated factor 6 ( TRAF 6 ) , and inhibits TAK 1 and TRAF 6 , but not NF kappa B inducing kinase ( NIK ) induced NF kappa B activation . . ^^^ |
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| Interacting proteins: O43318 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| Overexpression of ASK 1 inhibits IL 1 , TRAF 6 , or TAK 1 induced , but not NF kappaB inducing kinase induced , NF kappaB activation . ^^^ ASK 1 dissociates TAK 1 but not NF kappaB inducing kinase from TRAF 6 . ^^^ Moreover , IL 1 induced complex formation of endogenous TAK 1 and TRAF 6 was blocked by ASK 1 overexpression . ^^^ |
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| Interacting proteins: O43318 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| TAB 2 has previously been shown to interact with both TAK 1 and TRAF 6 and promote their association , thereby triggering subsequent IL 1 signaling events . ^^^ We show that IL 1 stimulation induces the rapid but transient association of IRAK , TRAF 6 , TAB 2 , and TAK 1 . ^^^ These results suggest that IRAK regulates the redistribution of TAB 2 upon IL 1 stimulation and facilitates the formation of a TRAF 6 TAB2 TAK 1 complex . ^^^ |
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| Interacting proteins: O43318 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| The goal of this study was to understand how IRAK activates the intermediate proteins TRAF 6 , TAK 1 , TAB 1 , and TAB 2 . ^^^ The translocation of TAB 2 and TRAF 6 is needed to form a TRAF 6 TAK1 TAB 1 TAB2 complex in the cytosol and thus activate TAK 1 . ^^^ |
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| Interacting proteins: O43318 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| Mac 1 dependent activation of NF kappaB was potentiated by wild type , and attenuated by dominant negative , TRAF 6 and TGF beta activated kinase ( TAK 1 ) constructs . ^^^ |
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| Interacting proteins: O43318 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| Ras participates in the activation of p 38 MAPK by interleukin 1 by associating with IRAK , IRAK 2 , TRAF 6 , and TAK 1 . ^^^ Our study suggests that upon activation Ras becomes associated with IRAK , Traf 6 , and TAK 1 , possibly aiding the assembly of this multiprotein signaling complex required for p 38 MAPK activation by IL 1 . . ^^^ |
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| Interacting proteins: O43318 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| Receptor activator of NF kappaB ligand ( RANKL ) activates TAK 1 mitogen activated protein kinase kinase kinase through a signaling complex containing RANK , TAB 2 , and TRAF 6 . ^^^ In the interleukin 1 signaling pathway , TAK 1 MAPK kinase kinase ( MAPKKK ) mediates MAPK and IKK activation via interaction with TRAF 6 , and TAB 2 acts as an adapter linking TAK 1 and TRAF 6 . ^^^ In 293 cells stably transfected with full length RANK , RANKL stimulation facilitates the formation of a complex containing RANK , TRAF 6 , TAB 2 , and TAK 1 , leading to the activation of TAK 1 . ^^^ These results suggest that the formation of the TRAF 6 TAB2 TAK 1 complex is involved in the RANK signaling pathway and may regulate the development and function of osteoclasts . . ^^^ |
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| Interacting proteins: O43318 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| IRAK then brings TRAF 6 to TAK 1 , TAB 1 , and TAB 2 , which are preassociated on the membrane before stimulation to form the membrane associated complex 2 . ^^^ The formation of complex 2 leads to the phosphorylation of TAK 1 and TAB 2 on the membrane by an unknown kinase , followed by the dissociation of TRAF 6 TAK1 TAB 1 TAB2 ( complex 3 ) from IRAK and consequent translocation of complex 3 to the cytosol . ^^^ |
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| Interacting proteins: O43318 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| Third , we showed that endogenous TAK 1 is phosphorylated by LPS stimulation , and that the association between TAK 1 and tumour necrosis factor receptor associated factor 6 ( TRAF 6 ) is constitutive and not induced by LPS treatment . ^^^ |
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| Interacting proteins: O43318 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| Recently , serine / threonine kinase TAK 1 and TAK 1 binding protein 1 and 2 ( TAB1 / 2 ) have been identified as molecules involved in IL 1 induced TRAF 6 mediated activation of AP 1 and NF kappa B via mitogen activated protein ( MAP ) kinases and 1 kappa B kinases , respectively . ^^^ |
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| Interacting proteins: O43318 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| Upon binding of dsRNA to TLR 3 , TRAF 6 , TAK 1 , and TAB 2 are recruited to the receptor to form a complex , which then translocates to the cytosol where TAK 1 is phosphorylated and activated . ^^^ |
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| Interacting proteins: O43318 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| Receptor proximal proteins involved in signalling by all TLRs include the adapter MyD 88 , 3 IRAKs ( IRAK 4 , IRAK and IRAK 2 ) , Tollip , Traf 6 and TAK 1 . ^^^ |
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| Interacting proteins: O43318 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| We also determined partial sequence information for myeloid differentiation factor 88 ( MyD 88 ) , two novel TLRs , TNF receptor associated factor 6 ( TRAF 6 ) , TGF beta activated kinase 1 ( TAK 1 ) , TAB 2 , inhibitor of nuclear factor kappa B kinase alpha ( IKK alpha ) and IKK beta . ^^^ |
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| Interacting proteins: O43318 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| TAB 2 , a TAK 1 binding protein , is involved in IL 1 induced NF kappaB activation by physically linking TAK 1 to TRAF 6 . ^^^ |
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| Interacting proteins: O43318 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| Instead , TRAF 6 , TAK 1 , and TAB 2 are recruited to TLR 3 on poly ( I . ^^^ TRAF 6 TAK1 TAB 2 are then translocated to the cytosol where TAK 1 is phosphorylated and activated , leading to the activation of IkappaB kinase and NFkappaB . ^^^ The present study addressed two important questions : ( 1 ) How are TRAF 6 , TAK 1 , and TAB 2 recruited to TLR 3 . ( 2 ) Are TRAF 6 , TAK 1 , and TAB 2 also required for TLR 3 mediated IRF 3 activation . ^^^ In support of this finding , we showed that DN TRAF 6 and DN TAK 1 blocked poly ( I . ^^^ |
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| Interacting proteins: O43318 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| The TRAF 6 ubiquitin ligase and TAK 1 kinase mediate IKK activation by BCL 10 and MALT 1 in T lymphocytes . ^^^ Here we present evidence that TRAF 6 ubiquitin ligase and TAK 1 protein kinase mediate IKK activation by BCL 10 and MALT 1 . ^^^ RNAi mediated silencing of MALT 1 , TAK 1 , TRAF 6 , and TRAF 2 suppressed TCR dependent IKK activation and interleukin 2 production in T cells . ^^^ Furthermore , we have reconstituted the pathway from BCL 10 to IKK activation in vitro with purified proteins of MALT 1 , TRAF 6 , TAK 1 , and ubiquitination enzymes including Ubc13 / Uev1A . ^^^ |
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| Interacting proteins: O43318 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| TAK 1 is in turn activated by TRAF 6 , a RING domain ubiquitin ligase that facilitates the synthesis of lysine 63 linked polyubiquitin chains . ^^^ |
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| Interacting proteins: O43318 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| TRAF 6 ( tumor necrosis factor receptor associated factor 6 ) is a RING ( really interesting new gene ) domain ubiquitin ( Ub ) ligase that mediates the activation of protein kinases , such as transforming growth factor beta activated kinase ( TAK 1 ) and IkappaB kinase ( IKK ) , by catalyzing the formation of a unique polyubiquitin chain linked through Lys 63 of Ub . ^^^ Furthermore , TIFA activates IKK in an in vitro reconstitution system consisting of purified proteins , including TRAF 6 , the TAK 1 kinase complex , and Ub conjugating enzyme complex Ubc 13 Uev1A . ^^^ Importantly , TIFA induces the oligomerization and polyubiquitination of TRAF 6 , which leads to the activation of TAK 1 and IKK through a proteasome independent mechanism . . ^^^ |
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| Interacting proteins: O43318 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| TAK 1 binding protein 2 facilitates ubiquitination of TRAF 6 and assembly of TRAF 6 with IKK in the IL 1 signaling pathway . ^^^ TAK 1 binding protein 2 ( TAB 2 ) was previously identified as an adaptor that links TAK 1 to an upstream signaling intermediate , tumor necrosis factor receptor associated factor 6 ( TRAF 6 ) . ^^^ Recently , ubiquitination of TRAF 6 was shown to play an essential role in the activation of TAK 1 . ^^^ |
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| Interacting proteins: O43318 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| This activation is inhibited by c Jun ( S73A ) , c Jun ( S63 / 73A ) , TAK 1 ( K63W ) , but not by p 38 ( AF ) , ERK 1 ( K71R ) , ERK 2 ( K52R ) and TRAF 6 ( C85A / H87A ) . ^^^ |
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| Interacting proteins: O43318 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| Upon TLR 3 activation , Rip 1 is also modified by polyubiquitin chains and is recruited to TLR 3 along with Traf 6 and the ubiquitin activated kinase Tak 1 . ^^^ |
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| Interacting proteins: O43318 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| TAB 2 is an adaptator protein that brigdes TRAF 6 ( TNF receptor associated factor 6 ) to TAK 1 ( TGFbeta activated kinase 1 ) , allowing TAK 1 activation and subsequent IKK activation . ^^^ TAB 2 , TRAF 6 and TAK 1 are involved in NF kappaB activation induced by the TNF receptor , Edar and its adaptator Edaradd . ^^^ Here , we show that endogenous and overexpressed TAB 2 , TRAF 6 and TAK 1 co immunoprecipitated with Edaradd in 293 cells . ^^^ Moreover , we show that dominant negative forms of TAB 2 , TRAF 6 and TAK 1 blocked the NF kappaB activation induced by Edaradd . ^^^ |
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| Interacting proteins: O43318 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| The C terminal activating region 2 of the Epstein Barr virus encoded latent membrane protein 1 activates NF kappaB through TRAF 6 and TAK 1 . ^^^ |
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| Interacting proteins: O43318 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| Protein interactions of exogenously expressed TNFR associated factor 6 ( TRAF 6 ) and MyD 88 or receptor interacting protein 2 and nucleotide binding oligomerization domain 1 or those of endogenous IkappaB kinase , TGF beta activated kinase 1 ( TAK 1 ) , and TRAF 6 were assessed by immunoprecipitation . ^^^ In human epithelial cells , H . pylori induced IkappaBalpha phosphorylation and IL 8 production were severely inhibited by siRNAs directed against TAK 1 , TRAF 6 , and MyD 88 . ^^^ H . pylori also induced TAK 1 and TRAF 6 complexes . ^^^ TAK 1 , TRAF 6 , and MyD 88 are important signal transducers in H . pylori infected human epithelial cells . . ^^^ |
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