| Interacting proteins: Q9UBE8 and O43318 |
Pubmed |
SVM Score :0.0 |
| Consistent with action in a common pathway , mom 4 and lit 1 exhibit similar mutant phenotypes and encode components of the mitogen activated protein kinase ( MAPK ) pathway that are homologous to vertebrate transforming growth factor beta activated kinase ( TAK 1 ) and NEMO like kinase ( NLK ) , respectively . ^^^ |
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| Interacting proteins: Q9UBE8 and O43318 |
Pubmed |
SVM Score :0.0 |
| MOM 4 and LIT 1 are homologous to TAK 1 ( a kinase activated by transforming growth factor beta ) mitogen activated protein kinase kinase kinase ( MAP3K ) and MAP kinase ( MAPK ) related NEMO like kinase ( NLK ) , respectively , in mammalian cells . ^^^ |
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| Interacting proteins: Q9UBE8 and O43318 |
Pubmed |
SVM Score :0.0 |
| Previously , we have shown that a specific mitogen activated protein ( MAP ) kinase pathway involving the MAP kinase kinase kinase TAK 1 and MAP kinase related Nemo like kinase ( NLK ) suppresses Wnt signaling . ^^^ |
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| Interacting proteins: Q9UBE8 and O43318 |
Pubmed |
SVM Score :0.0 |
| Here , we show that TGF beta activated kinase 1 ( TAK 1 ) interacts with STAT 3 , that the TAK 1 Nemo like kinase ( NLK ) pathway is efficiently activated by IL 6 through the YXXQ motif , and that this is the YXXQ mediated H 7 sensitive pathway that leads to STAT 3 Ser 727 phosphorylation . ^^^ |
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| Interacting proteins: Q9UBE8 and O43318 |
Pubmed |
SVM Score :0.0 |
| Recently we have shown that c Myb is degraded in response to Wnt 1 stimulation via a pathway involving TAK 1 ( TGF beta activated kinase ) , HIPK 2 ( homeodomain interacting protein kinase 2 ) , and NLK ( Nemo like kinase ) . ^^^ |
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| Interacting proteins: Q9UBE8 and O43318 |
Pubmed |
SVM Score :0.0 |
| Recent evidence suggests that a specific MAP kinase pathway involving the MAP kinase kinase kinase TAK 1 and the MAP kinase NLK counteract Wnt signalling . ^^^ In particular , homologues of TAK 1 and NLK , MOM 4 and LIT 1 , negatively regulate Wnt controlled cell fate decision in the early Caenorhabditis elegans embryo . ^^^ Moreover , TAK 1 activates NLK , which phosphorylates TCFs bound to ( beta ) catenin . ^^^ In addition , alterations in TAK 1 NLK might play a role in cancer . . ^^^ |
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| Interacting proteins: Q9UBE8 and O43318 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Recent evidence suggests that a specific MAP kinase pathway involving the MAP kinase kinase kinase TAK 1 and the MAP kinase NLK counteract Wnt signalling . ^^^ In particular , it has been shown that TAK 1 activates NLK , which phosphorylates TCFs bound to beta catenin . ^^^ |
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| Interacting proteins: Q9UBE8 and O43318 |
Pubmed |
SVM Score :0.0 |
| The TAK 1 NLK mitogen activated protein kinase cascade functions in the Wnt 5a / Ca ( 2+ ) pathway to antagonize Wnt / beta catenin signaling . ^^^ The mitogen activated protein kinase ( MAPK ) pathway composed of TAK 1 MAPK kinase kinase and NLK MAPK also negatively regulates the canonical Wnt / beta catenin signaling pathway . ^^^ Here we show that activation of CaMKII induces stimulation of the TAK 1 NLK pathway . ^^^ Overexpression of Wnt 5a in HEK 293 cells activates NLK through TAK 1 . ^^^ Furthermore , by using a chimeric receptor ( beta ( 2 ) AR Rfz 2 ) containing the ligand binding and transmembrane segments from the beta ( 2 ) adrenergic receptor ( beta ( 2 ) AR ) and the cytoplasmic domains from rat Frizzled 2 ( Rfz 2 ) , stimulation with the beta adrenergic agonist isoproterenol activates activities of endogenous CaMKII , TAK 1 , and NLK and inhibits beta catenin induced transcriptional activation . ^^^ |
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| Interacting proteins: Q9UBE8 and O43318 |
Pubmed |
SVM Score :0.0 |
| Recent evidence suggests that a specific MAP kinase pathway involving the MAP kinase kinase kinase TAK 1 and the MAP kinase NLK counteract Wnt signalling . ^^^ |
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| Interacting proteins: Q9UBE8 and O43318 |
Pubmed |
SVM Score :0.0 |
| Recently we have shown that the c myb proto oncogene product ( c Myb ) is degraded in response to Wnt 1 signaling via the pathway involving TAK 1 ( transforming growth factor beta activated kinase ) , HIPK 2 ( homeodomain interacting protein kinase 2 ) , and NLK ( Nemo like kinase ) . ^^^ |
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| Interacting proteins: Q9UBE8 and O43318 |
Pubmed |
SVM Score :0.0 |
| Role of the TAK 1 NLK STAT 3 pathway in TGF beta mediated mesoderm induction . ^^^ Transforming growth factor ( TGF ) beta activated kinase 1 ( TAK 1 ) and Nemo like kinase ( NLK ) function in Xenopus , Drosophila , and Caenorhabditis elegans development . ^^^ Here we report that serine phosphorylation of STAT 3 induced by TAK 1 NLK cascade is essential fo TGF beta mediated mesoderm induction in Xenopus embryo . ^^^ Depletion of TAK 1 , NLK , or STAT 3 blocks TGF beta mediated mesoderm induction . ^^^ Moreover , depletion of either TAK 1 or NLK inhibits endogenous serine phosphorylation of STAT 3 . ^^^ |
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| Interacting proteins: Q9UBE8 and O43318 |
Pubmed |
SVM Score :0.0 |
| Wnt 1 signal induces phosphorylation and degradation of c Myb protein via TAK 1 , HIPK 2 , and NLK . ^^^ Here we report that c Myb protein is phosphorylated and degraded by Wnt 1 signal via the pathway involving TAK 1 ( TGF beta activated kinase ) , HIPK 2 ( homeodomain interacting protein kinase 2 ) , and NLK ( Nemo like kinase ) . ^^^ Wnt 1 signal causes the nuclear entry of TAK 1 , which then activates HIPK 2 and the mitogen activated protein ( MAP ) kinase like kinase NLK . ^^^ |
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| Interacting proteins: Q9UBE8 and O43318 |
Pubmed |
SVM Score :0.0 |
| Dishevelled independent WNT / PCP signals are transduced to the NLK signaling cascade through MAP3K7 ( TAK 1 ) . ^^^ |
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