| Interacting proteins: Q9NYJ8 and O43318 |
Pubmed |
SVM Score :1.4025734 |
| TAB 2 has previously been shown to interact with both TAK 1 and TRAF 6 and promote their association , thereby triggering subsequent IL 1 signaling events . 1.4025734^^^ |
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| Interacting proteins: Q9NYJ8 and O43318 |
Pubmed |
SVM Score :0.0 |
| TAK 1 binding protein 2 facilitates ubiquitination of TRAF 6 and assembly of TRAF 6 with IKK in the IL 1 signaling pathway . ^^^ TAK 1 binding protein 2 ( TAB 2 ) was previously identified as an adaptor that links TAK 1 to an upstream signaling intermediate , tumor necrosis factor receptor associated factor 6 ( TRAF 6 ) . ^^^ |
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| Interacting proteins: Q9NYJ8 and O43318 |
Pubmed |
SVM Score :0.0 |
| To gain further insight into the mechanism of IKK activation by Edar and Edaradd , we performed a yeast two hybrid screen and isolated TAB 2 ( TAK 1 binding protein 2 ) as a binding partner of Edaradd . ^^^ |
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| Interacting proteins: Q9NYJ8 and O43318 |
Pubmed |
SVM Score :0.0 |
| Here we demonstrate that TAK 1 mitogen activated protein kinase kinase kinase and TAK 1 binding protein 2 ( TAB 2 ) , together with TRAF 6 , are recruited to LMP 1 through its N terminal transmembrane region . ^^^ |
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| Interacting proteins: Q9NYJ8 and O43318 |
Pubmed |
SVM Score :0.0 |
| The yeast two hybrid system has now revealed two human proteins , termed TAB 1 and TAB 2 ( for TAK 1 binding protein ) , that interact with TAK 1 . ^^^ |
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| Interacting proteins: Q9NYJ8 and O43318 |
Pubmed |
SVM Score :0.0 |
| TAB 2 , a novel adaptor protein , mediates activation of TAK 1 MAPKKK by linking TAK 1 to TRAF 6 in the IL 1 signal transduction pathway . ^^^ Here we report the identification of TAB 2 , a novel intermediate in the IL 1 pathway that functionally links TAK 1 to TRAF 6 . ^^^ IL 1 stimulates translocation of TAB 2 from the membrane to the cytosol where it mediates the IL 1 dependent association of TAK 1 with TRAF 6 . ^^^ These results define TAB 2 as an adaptor linking TAK 1 and TRAF 6 and as a mediator of TAK 1 activation in the IL 1 signaling pathway . . ^^^ |
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| Interacting proteins: Q9NYJ8 and O43318 |
Pubmed |
SVM Score :0.0 |
| Here we report the purification and identification of TRIKA 2 , which is composed of TAK 1 , TAB 1 and TAB 2 , a protein kinase complex previously implicated in IKK activation through an unknown mechanism . ^^^ |
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| Interacting proteins: Q9NYJ8 and O43318 |
Pubmed |
SVM Score :0.0 |
| The goal of this study was to understand how IRAK activates the intermediate proteins TRAF 6 , TAK 1 , TAB 1 , and TAB 2 . ^^^ The translocation of TAB 2 and TRAF 6 is needed to form a TRAF 6 TAK1 TAB 1 TAB2 complex in the cytosol and thus activate TAK 1 . ^^^ Our results show that IRAK is required for the IL 1 induced phosphorylation of TAK 1 , TAB 1 , and TAB 2 . ^^^ |
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| Interacting proteins: Q9NYJ8 and O43318 |
Pubmed |
SVM Score :0.0 |
| Receptor activator of NF kappaB ligand ( RANKL ) activates TAK 1 mitogen activated protein kinase kinase kinase through a signaling complex containing RANK , TAB 2 , and TRAF 6 . ^^^ In the interleukin 1 signaling pathway , TAK 1 MAPK kinase kinase ( MAPKKK ) mediates MAPK and IKK activation via interaction with TRAF 6 , and TAB 2 acts as an adapter linking TAK 1 and TRAF 6 . ^^^ Here , we demonstrate that TAK 1 and TAB 2 participate in the RANK signaling pathway . ^^^ Dominant negative forms of TAK 1 and TAB 2 inhibit NF kappaB activation induced by overexpression of RANK . ^^^ In 293 cells stably transfected with full length RANK , RANKL stimulation facilitates the formation of a complex containing RANK , TRAF 6 , TAB 2 , and TAK 1 , leading to the activation of TAK 1 . ^^^ |
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| Interacting proteins: Q9NYJ8 and O43318 |
Pubmed |
SVM Score :0.0 |
| Interleukin 1 ( IL 1 ) receptor associated kinase dependent IL 1 induced signaling complexes phosphorylate TAK 1 and TAB 2 at the plasma membrane and activate TAK 1 in the cytosol . ^^^ IRAK then brings TRAF 6 to TAK 1 , TAB 1 , and TAB 2 , which are preassociated on the membrane before stimulation to form the membrane associated complex 2 . ^^^ The formation of complex 2 leads to the phosphorylation of TAK 1 and TAB 2 on the membrane by an unknown kinase , followed by the dissociation of TRAF 6 TAK1 TAB 1 TAB2 ( complex 3 ) from IRAK and consequent translocation of complex 3 to the cytosol . ^^^ |
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| Interacting proteins: Q9NYJ8 and O43318 |
Pubmed |
SVM Score :0.0 |
| Upon binding of dsRNA to TLR 3 , TRAF 6 , TAK 1 , and TAB 2 are recruited to the receptor to form a complex , which then translocates to the cytosol where TAK 1 is phosphorylated and activated . ^^^ |
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| Interacting proteins: Q9NYJ8 and O43318 |
Pubmed |
SVM Score :0.0 |
| We also determined partial sequence information for myeloid differentiation factor 88 ( MyD 88 ) , two novel TLRs , TNF receptor associated factor 6 ( TRAF 6 ) , TGF beta activated kinase 1 ( TAK 1 ) , TAB 2 , inhibitor of nuclear factor kappa B kinase alpha ( IKK alpha ) and IKK beta . ^^^ |
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| Interacting proteins: Q9NYJ8 and O43318 |
Pubmed |
SVM Score :0.0 |
| TAB 2 , a TAK 1 binding protein , is involved in IL 1 induced NF kappaB activation by physically linking TAK 1 to TRAF 6 . ^^^ Here we report the identification and characterization of a novel protein designated TAB 3 , a TAB 2 like molecule that associates with TAK 1 and can activate NF kappaB similar to TAB 2 . ^^^ Cotransfection of siRNAs directed against both TAB 2 and TAB 3 inhibit both IL 1 and TNF induced activation of TAK 1 and NF kappaB . ^^^ These results suggest that TAB 2 and TAB 3 function redundantly as mediators of TAK 1 activation in IL 1 and TNF signal transduction . . ^^^ |
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| Interacting proteins: Q9NYJ8 and O43318 |
Pubmed |
SVM Score :0.0 |
| We have identified a new binding partner of the TGFbeta ( transforming growth factor beta ) activated protein kinase ( TAK 1 ) , termed TAB 3 ( TAK 1 binding protein 3 ) , which shares 48 % amino acid sequence identity with TAB 2 . ^^^ One comprises TAK 1 complexed with TAB 1 and TAB 2 , and the other TAK 1 complexed with TAB 1 and TAB 3 . ^^^ The SAPK2a / p38alpha mediated phosphorylation of TAB 2 and TAB 3 may contribute to the SAPK2a / p38alpha mediated feedback control of TAK 1 activity that also involves the phosphorylation of TAB 1 . ^^^ |
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| Interacting proteins: Q9NYJ8 and O43318 |
Pubmed |
SVM Score :0.0 |
| Instead , TRAF 6 , TAK 1 , and TAB 2 are recruited to TLR 3 on poly ( I . ^^^ TRAF 6 TAK1 TAB 2 are then translocated to the cytosol where TAK 1 is phosphorylated and activated , leading to the activation of IkappaB kinase and NFkappaB . ^^^ The present study addressed two important questions : ( 1 ) How are TRAF 6 , TAK 1 , and TAB 2 recruited to TLR 3 . ( 2 ) Are TRAF 6 , TAK 1 , and TAB 2 also required for TLR 3 mediated IRF 3 activation . ^^^ |
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| Interacting proteins: Q9NYJ8 and O43318 |
Pubmed |
SVM Score :0.0 |
| In contrast , two TAK 1 binding proteins , TAB 1 and TAB 2 , which are involved in the activation of TAK 1 , were localized in the neurites and the nuclei of the differentiating cells , respectively . ^^^ |
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| Interacting proteins: Q9NYJ8 and O43318 |
Pubmed |
SVM Score :0.0 |
| The activation of NF kappaB and IKK requires an upstream kinase complex consisting of TAK 1 and adaptor proteins such as TAB 1 , TAB 2 , or TAB 3 . ^^^ Mutations of the ZnF domain abolish the ability of TAB 2 and TAB 3 to bind polyubiquitin chains , as well as their ability to activate TAK 1 and IKK . ^^^ Significantly , replacement of the ZnF domain with a heterologous ubiquitin binding domain restored the ability of TAB 2 and TAB 3 to activate TAK 1 and IKK . ^^^ |
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| Interacting proteins: Q9NYJ8 and O43318 |
Pubmed |
SVM Score :0.0 |
| Critical roles of threonine 187 phosphorylation in cellular stress induced rapid and transient activation of transforming growth factor beta activated kinase 1 ( TAK 1 ) in a signaling complex containing TAK 1 binding protein TAB 1 and TAB 2 . ^^^ RNA interference and overexpression experiments demonstrated that TAK 1 binding protein TAB 1 and TAB 2 were involved in the phosphorylation of TAK 1 , but they regulated TAK 1 phosphorylation differentially . ^^^ |
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| Interacting proteins: Q9NYJ8 and O43318 |
Pubmed |
SVM Score :0.0 |
| TAK 1 , but not TAB 1 or TAB 2 , plays an essential role in multiple signaling pathways in vivo . ^^^ Although in vitro biochemical studies have revealed the existence of a TAK 1 complex , which includes TAK 1 and the adapter proteins TAB 1 and TAB 2 , it remains unclear which members of this complex are essential for signaling . ^^^ Using embryonic fibroblasts lacking TAK 1 , TAB 1 , or TAB 2 , we have found that TNFR 1 , IL 1R , TLR 3 , and TLR 4 mediated NF kappaB and AP 1 activation are severely impaired in Tak 1 ( m / m ) cells , but they are normal in Tab 1 ( / ) and Tab 2 ( / ) cells . ^^^ |
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| Interacting proteins: Q9NYJ8 and O43318 |
Pubmed |
SVM Score :0.0 |
| Activation of TAK 1 in mammals is mediated by two TAK 1 binding proteins , TAB 1 and TAB 2 , but the role of the TAB proteins in the immune response of Drosophila has not yet been established . ^^^ |
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| Interacting proteins: Q9NYJ8 and O43318 |
Pubmed |
SVM Score :0.0 |
| New genes candidates for ectodermal dysplasia : TAB 2 , TRAF 6 and TAK 1 ] . ^^^ |
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| Interacting proteins: Q9NYJ8 and O43318 |
Pubmed |
SVM Score :0.0 |
| YopP , but not the catalytically inactive mutant YopP ( C172A ) , also suppresses basal and interleukin 1 inducible activation of endogenous TAK 1 , TAB 1 and TAB 2 . ^^^ YopP does not affect the interaction of TAK 1 , TAB 1 and TAB 2 but inhibits autophosphorylation of TAK 1 at Thr 187 and phosphorylation of TAB 1 at Ser 438 . ^^^ Glutathione S transferase tagged YopP ( GST YopP ) binds to MAPK kinase ( MAPKK ) 4 and TAB 1 but not to TAK 1 or TAB 2 in vitro . ^^^ |
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| Interacting proteins: Q9NYJ8 and O43318 |
Pubmed |
SVM Score :0.0 |
| NA |
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