| Interacting proteins: Q99683 and O43318 |
Pubmed |
SVM Score :0.82831879 |
| Here we report that ASK 1 binds to TAK 1 and dissociates TAK 1 from TNF receptor associated factor 6 ( TRAF 6 ) , and inhibits TAK 1 and TRAF 6 , but not NF kappa B inducing kinase ( NIK ) induced NF kappa B activation . . 0.82831879^^^ |
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| Interacting proteins: Q99683 and O43318 |
Pubmed |
SVM Score :1.0763842 |
| Here we show that ASK 1 directly interacts with transforming growth factor beta activated kinase 1 ( TAK 1 ) , another MAPKKK that has been identified as a signaling intermediate in the interleukin 1 ( IL 1 ) induced NF kappaB pathway as well as the transforming growth factor beta superfamily induced JNK / p38 pathway . 1.0763842^^^ |
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| Interacting proteins: Q99683 and O43318 |
Pubmed |
SVM Score :0.0 |
| Here , we report that the expression of mitogen activated protein ( MAP ) kinase / extracellular signal regulated kinase kinase kinase 1 ( MEKK 1 ) , transforming growth factor beta activated kinase ( TAK 1 ) , and apoptosis signal regulating kinase ( ASK 1 ) in HepG 2 cells activated the ARE reporter gene , whereas the expression of their dominant negative mutants impaired ARE activation by the chemicals sodium arsenite and mercury chloride . ^^^ Coexpression of downstream kinases , MAP kinase kinase 4 , MAP kinase kinase 6 , and c Jun NH ( 2 ) terminal kinase 1 , but not MAP kinase kinase 3 and p 38 , augmented ARE activation by MEKK 1 , TAK 1 , and ASK 1 . ^^^ The coexpression of a basic leucine zipper transcription factor Nrf 2 but not c Jun also greatly enhanced the activation of reporter gene by MEKK 1 , TAK 1 , and ASK 1 ; however , a dominant negative mutant of Nrf 2 ( NF E 2 related factor 2 ) blocked this event . ^^^ Furthermore , when overexpressed , MEKK 1 , TAK 1 , and ASK 1 induced the expression of heme oxygenase 1 , a gene regulated by ARE , and the cotransfection with the dominant negative mutant of Nrf 2 abolished the induction . ^^^ Taken together , these results suggest that MAP kinase pathways that are activated by MEKK 1 , TAK 1 , and ASK 1 may link chemical signals to Nrf 2 , leading to the activation of ARE dependent genes . . ^^^ |
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| Interacting proteins: Q99683 and O43318 |
Pubmed |
SVM Score :0.0 |
| LTbetaR mediated IL 8 response was inhibited by the dominant negative mutants of ASK 1 , MKK 4 , MKK 7 , and JNK , but not by those of MEKK 1 , TAK 1 , MEK , ERK , and p 38 MAPK . ^^^ |
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| Interacting proteins: Q99683 and O43318 |
Pubmed |
SVM Score :0.0 |
| This compound did not effectively inhibit the catalytic activities of the MEKK 1 or ASK 1 MAPKKKs , suggesting that 5Z 7 oxozeaenol is a selective inhibitor of TAK 1 . ^^^ |
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| Interacting proteins: Q99683 and O43318 |
Pubmed |
SVM Score :0.0 |
| The DVD sites bind to their specific upstream MAP kinase kinase kinases ( MAPKKKs ) , including MTK 1 ( MEKK 4 ) , ASK 1 , TAK 1 , TAO 2 , MEKK 1 , and Raf 1 . ^^^ |
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| Interacting proteins: Q99683 and O43318 |
Pubmed |
SVM Score :0.0 |
| NA |
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