| Interacting proteins: Q92918 and O43318 |
Pubmed |
SVM Score :0.70421159 |
| In addition , interaction between HPK 1 and TAK 1 was observed in transient transfection assays , and this interaction was enhanced by TGF beta treatment . 0.70421159^^^ |
|
| Interacting proteins: Q92918 and O43318 |
Pubmed |
SVM Score :0.0 |
| Dominant negative mutants of HPK 1 downstream effectors , including MEKK 1 , TAK 1 , and SEK 1 , also inhibited Crk induced JNK activation . ^^^ |
|
| Interacting proteins: Q92918 and O43318 |
Pubmed |
SVM Score :0.0 |
| Activation of the hematopoietic progenitor kinase 1 ( HPK 1 ) dependent , stress activated c Jun N terminal kinase ( JNK ) pathway by transforming growth factor beta ( TGF beta ) activated kinase ( TAK 1 ) , a kinase mediator of TGF beta signal transduction . ^^^ A kinasedefective mutant of TAK 1 effectively suppressed hematopoietic progenitor kinase 1 ( HPK 1 ) induced JNK activity but had little effect on germinal center kinase activation of JNK . ^^^ Taken together , these results identify TAK 1 as a regulator in the HPK 1 > TAK 1 > MKK4 / SEK1 > JNK kinase cascade and indicate the involvement of JNK in the TGF beta signaling pathway . ^^^ |
|
| Interacting proteins: Q92918 and O43318 |
Pubmed |
SVM Score :0.0 |
| In transfection assays , curcumin moderately suppressed MEKK 1 induced JNK activation ; however , it effectively blocked JNK activation caused by co transfection of TAK 1 , GCK , or HPK 1 . ^^^ |
|