| Sef interacts with TAK 1 and mediates JNK activation and apoptosis . 0.6714636^^^ Here we show that Sef and a deletion mutant of Sef lacking the extracellular domain ( SefIC ) physically interact with TAK 1 ( transforming growth factor beta associated kinase ) and activate JNK through a TAK 1 MKK4 JNK pathway . 0.53973816^^^ |